fNIRS-based monitoring of the neural substrate of inhibitory control in ADHD children
Project/Area Number |
24791083
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | NIRS / ADHD / プラセボ / MPH / ATX / Go/NoGo / Oddball / fNIRS / prefrontal |
Outline of Final Research Achievements |
fNIRS is a noninvasive and unrestrictive method of functional neuroimaging. Making the most of fNIRS’s merits, we have explored the neural substrate of inhibitory and attentional controls in ADHD children. Firstly, our fNIRS-based measurements successfully visualized the hypoactivation pattern in the right prefrontal and parietal cortex during an inhibition and attention task in ADHD children compared with typically developing control at a group level using fNIRS. Secondly, we clarified a method of individual classification between ADHD and typically developing control children using fNIRS with high classification accuracy with 90% sensitivity. Finally, we explored neuropharmacological effect of ADHD medications using double-blinded placebo study. Then the reduction of right prefrontaland parietal activation was normalized after taking ADHD medications, such as MPH and ATX.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Neuropharmacological effect of atomoxetine on attention network in children with attention deficit/hyperactivity disorder during oddball paradigms as assessed using fNIRS2014
Author(s)
Nagashima M, Monden Y*,Dan I, Dan H, Tsuzuki D, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Watanabe E, and Yamagata T
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Journal Title
Neurophotonics
Volume: 1(2)
Pages: 1-14
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: an fNIRS study2014
Author(s)
Nagashima M, Monden Y*,Dan I, Dan H, Tsuzuki D, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Watanabe E, and Yamagata T,
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Journal Title
NeuroImage:Clinical
Volume: 6
Pages: 192-201
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit/hyperactivity disorder during oddball paradigms as assessed using fNIRS2014
Author(s)
Nagashima M, Monden Y*,Dan I, Dan H, Tsuzuki D, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Watanabe E, and Yamagata T
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Journal Title
Neurophotonics
Volume: 1(1)
Pages: 1-15
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit/hyperactivity disorder during oddball paradigms as assessed using fNIRS2014
Author(s)
Masako Nagashima, Yukifumi Monden(Corr), Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Mariko Y. Momoi, Eiju Watanabe, and Takanori Yamagata
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Journal Title
Neurophotonics
Volume: accepted
Related Report
Peer Reviewed
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