Brain function elucidation which integrated brain function imaging analysis with genetic analysis in the ADHD
Project/Area Number |
24791085
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
|
Research Institution | Jichi Medical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | fNIRS / ADHD / 抑制機能障害 / 注意機能障害 / 塩酸メチルフェニデート / アトモキセチン / fNIRS / WISC / プラセボ / ドパミン関連遺伝子 / CNV / 遺伝子多型 / 自閉症 |
Outline of Final Research Achievements |
ADHD is characterized mainly by dysfunction in inhibition and attention. Methylphenidate (MPH) and Atomoxetine (ATX) have been recommended as a primary medication. We examined the pharmacological effects of MPH and ATX in ADHD children using fNIRS in a randomized, double-blind, placebo-controlled, crossover design during an inhibition and attention task. Firstly, our fNIRS-based measurements visualized both medications modulated hemodynamic responses in the right prefrontal cortex (rPFC) during an inhibition task while pre-medication and a placebo did not in ADHD. Secondly, we visualized MPH modulated hemodynamic responses in rPFC and ATX in rPFC and the right inferior parietal lobe (rIPL) during an attention task while pre-medication and a placebo did not in ADHD. Consequently, our studies reveal that the activation pattern in rIPL could serve as an objective neurobiological marker to differentiate the neuropharmacological effects of ATX and MPH on ADHD regarding attentional control.
|
Report
(4 results)
Research Products
(22 results)
-
[Journal Article] Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy2014
Author(s)
Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Tsutomu Mizutani, Daisuke Tsuzuki, Yasushi Kyutoku, Yuji Gunji, Daisuke Hirano, Takamichi Taniguchi, Hideo Shimoizumi, Mariko Y. Momoi, Takanori Yamagata, Eiju Watanabe
-
Journal Title
Neurophotonics
Volume: 1
Issue: 2
Pages: 0250071-14
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: an fNIRS study2014
Author(s)
Nagashima M, Monden Y*,Dan I, Dan H, Tsuzuki D, Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Hirano D, Taniguchi T, Shimoizumi H, Momoi MY, Watanabe E, and Yamagata T,
-
Journal Title
NeuroImage:Clinical
Volume: 6
Pages: 192-201
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy2014
Author(s)
Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Mariko Y. Momoi, Eiju Watanabe, Takanori Yamagata
-
Journal Title
Neurophotonics
Volume: 1
Issue: 1
Pages: 0150011-15
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.2014
Author(s)
Masako Nagashima,Yukifumi Monden,Ippeita Dan,Haruka Dan,Daisuke Tsuzuki,Tsutomu Mizutani,Yasushi Kyutoku,Yuji Gunji,Mariko Y. Momoi,Eiju Watanabe, Takanori Yamagata
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-