The Role of Annexin in Pregnant woman
| Project/Area Number |
24791117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
MATSUMOTO Makiko 大阪市立大学, 医学(系)研究科(研究院), 登録医 (50599298)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Annexin A2 / 胎盤 / 妊娠高血圧症 / Preeclampsia / 胎盤絨毛 / Annexin A２ / Annexin A5 / syncytiotrophoblast |
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| Outline of Final Research Achievements |
The underlying pathogenic mechanism of preeclammpsia(PE) remains unclear. It is thought to be associated with uteroplacental ischemia and endothelial dysfunction. Annexin A2,including syncytiotrophoblasts, is a member of Annexin family.
Placental expression of Annexin A2 as determined by immunohistochemistry was signifiantly higher in PE groups compared with the uncompliated pregnancy group. Placental Annexin A2 mRNA expression was significantly elevated in group 2(PE cases with acute worsening of symptoms necessitating immediate pregnancy termination) compared with the normal pregnancy group and group 1(PE cases without emergency termination of pregnancy).
These fidings suggest that worsening of PE might alter Annexin A2 expression at the transcription level.
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Report
(4 results)
Research Products
(4 results)
