Regulation of deep vein thrombosis by adhesion molecules

• Project/Area Number: 24791139
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: KUWANO Yoshihiro 東京大学, 医学部附属病院, 講師 (60625044)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 深部静脈血栓症 / 炎症細胞浸潤 / sling / 細胞接着分子 / スリング

Research Abstract

Rolling neutrophils form very unique structure called "sling" at the front of rolling cells, and this structure stabilizes the rolling at high shear stresses. Our data suggest that the behavior of adhesion molecules on sling plays important role in deep vein thrombosis since the migration of inflammatory cells occurs at relatively high shear stresses.

Research Products

• [Journal Article] Serum levels of mannose-binding lectin in systemic sclerosis: A possible contribution to the initiation of skin sclerosis in the diffuse cutaneous subtype (2014)
  • Author(s): Akamata K, Asano Y, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 1 Pages: 123
  • DOI: 10.1684/ejd.2013.2245
  • Peer Reviewed
• [Journal Article] Circulating galectin-1 concentrations in systemic sclerosis: potential contribution to digital vasculopathy (2014)
  • Author(s): Yanaba K, Asano Y, Akamata K, Noda S, Aozasa N, Taniguchi T, Takahashi T, Toyama T, Ichimura Y, Sumida H, Kuwano Y, Miyazaki M, Sato S
  • Journal Title: Int J Rheum Dis Volume: 19 Issue: 6 Pages: 622
  • DOI: 10.1111/1756-185x.12288
  • Peer Reviewed
• [Journal Article] Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis (2014)
  • Author(s): Ichimura Y, Asano Y, Akamata K, Takahashi T, Noda S, Taniguchi T, Toyama T, Aozasa N, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T
  • Journal Title: Arch Dermatol Res Volume: 306 Issue: 4 Pages: 331
  • DOI: 10.1007/s00403-013-1431-9
  • Peer Reviewed
• [Journal Article] Serum Angiopoietin-like Protein 3 Levels : Possible Correlation with Progressive Skin Sclerosis, Digital Ulcers and Pulmonary Vascular Involvement in Patients with Systemic Sclerosis (2014)
  • Author(s): Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T
  • Journal Title: Acta Derm Venereol Volume: 94(2) Pages: 157-62
  • Peer Reviewed
• [Journal Article] Serum levels of mannose-binding lectin in systemic sclerosis: a possible contribution to the initiation of skin sclerosis in the diffuse cutaneous subtype. (2014)
  • Author(s): Akamata K, Asano Y, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Eur J Dermatol. Volume: 24 Pages: 123-125
  • Peer Reviewed
• [Journal Article] Serum angiopoietin-like protein 3 levels: Possible correlation with progressive skin sclerosis, digital ulcers and pulmonary vascular involvement in patients with systemic sclerosis (2014)
  • Author(s): Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T
  • Journal Title: Acta Derm Venereol. Volume: 94 Issue: 2 Pages: 157
  • DOI: 10.2340/00015555-1680
  • Peer Reviewed
• [Journal Article] Propranolol is more effective than pulsed dye laser and cryosurgery for infantile hemangiomas (2013)
  • Author(s): Kagami S, Kuwano Y, Shibata S, Uwajima Y, Yamada D, Miyamoto A, Miyagawa T, Araki M, Takahashi K, Isomura S, Aozasa N, Masui Y, Yamamoto M, Inuzuka R, Katori T, Sato S
  • Journal Title: Eur J Pediatr. Volume: 172 Issue: 11 Pages: 1521
  • DOI: 10.1007/s00431-013-2075-7
  • Peer Reviewed
• [Journal Article] Aninverse correlation of serum angiogenin levels with estimated glomerular filtration rate in systemic sclerosis patients with renal dysfunction (2013)
  • Author(s): Akamata K, Asano Y, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Eur J Dermatol Volume: 23 Issue: 2 Pages: 269
  • DOI: 10.1684/ejd.2013.1924
  • Peer Reviewed
• [Journal Article] スリングは高ずり応力下における好中球ローリングを可能にする (2013)
  • Author(s): 桑野嘉弘
  • Journal Title: 実験医学 Volume: 31(3) Pages: 433-436
• [Journal Article] Decreased cathepsin V expression due to fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis (2013)
  • Author(s): Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Rheumatology (Oxford) Volume: 52 Issue: 5 Pages: 790
  • DOI: 10.1093/rheumatology/kes379
  • Peer Reviewed
• [Journal Article] Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis (2013)
  • Author(s): Noda S, Asano Y, Aozasa N, Akamata K, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S:
  • Journal Title: Arch Dermatol Res. Volume: 305 Issue: 4 Pages: 325
  • DOI: 10.1007/s00403-012-1307-4
  • Peer Reviewed
• [Journal Article] Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis (2013)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Arch Dermatol Res Volume: 305 Issue: 1 Pages: 17
  • DOI: 10.1007/s00403-012-1292-7
  • Peer Reviewed
• [Journal Article] Increased circulating fibrinogen-like protein 2 in patients with systemic sclerosis (2013)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S:
  • Journal Title: Clin Rheumatol Volume: 32 Issue: 1 Pages: 43
  • DOI: 10.1007/s10067-012-2089-y
  • Peer Reviewed
• [Journal Article] Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis. (2013)
  • Author(s): Noda S, Asano Y, Aozasa N, Akamata K, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Arch Dermatol Res Volume: 現在、電子版のみ公開。印刷中。
  • Peer Reviewed
• [Journal Article] Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. (2013)
  • Author(s): Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Rheumatology (Oxford) Volume: 現在、電子版のみ公開。印刷中。
  • Peer Reviewed
• [Journal Article] An inverse correlation of serum angiogenin levels with estimated glomerular filtration rate in systemic sclerosis patients with renal dysfunction. (2013)
  • Author(s): Akamata K, Asano Y, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: Eur J Dermatol Volume: 現在、電子版のみ公開。印刷中。
  • Peer Reviewed
• [Journal Article] スリングは高ずり応力下における好中球ローリングを可能にする (2013)
  • Author(s): 桒野嘉弘
  • Journal Title: 実験医学 Volume: 31 Pages: 433-436
• [Journal Article] Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis (2012)
  • Author(s): Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S
  • Journal Title: Br J Dermatol Volume: 167(3) Pages: 542-7
  • Peer Reviewed
• [Journal Article] Slings enable neutrophil rolling at high shear (2012)
  • Author(s): Sundd P, Gutierrez E, Koltsova EK, Kuwano Y, Fukuda S, Pospieszalska MK, Groisman A, Ley K
  • Journal Title: Nature Volume: 488 Issue: 7411 Pages: 399
  • DOI: 10.1038/nature11248
  • Peer Reviewed
• [Journal Article] Lymphatic dysfunction impairs antigen-specific immunization, but augments tissue swelling following contact with allergens (2012)
  • Author(s): Sugaya M, Kuwano Y, Suga H, Miyagaki T, Ohmatsu H, Kadono T, Okochi H, Blauvelt A, Tamaki K, Sato S.
  • Journal Title: J Invest Dermatol Volume: 132 Issue: 3 PART 1 Pages: 667
  • DOI: 10.1038/jid.2011.349
  • Peer Reviewed
• [Journal Article] Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis
  • Author(s): Sumida H, Asano Y, Hatano M, Aozasa N, Toyama T, Akamata K, Miyazaki M, Taniguchi T, Takahashi T, Ichimura Y, Noda S, Kuwano Y, Yanaba K, Sato S
  • Journal Title: Mod Rheumatol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Serum resistin levels : a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis
  • Author(s): Masui Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T
  • Journal Title: Rheumatol Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Histological features of localized scleroderma 'en coup de sabre' : a study of 16 cases
  • Author(s): Taniguchi T, Asano Y, Tamaki Z, Akamata K, Aozasa N, Noda S, Takahashi T, Ichimura Y, Toyama T, Sugita M, Sumida H, Kuwano Y, Miyazaki M, Yanaba K, Sato S
  • Journal Title: J Eur Acad Dermatol Venereol Volume: (in press)
  • Peer Reviewed
• [Presentation] Gi2 and Gi3 differentially regulate arrest and chemotaxis in neutrophils (2013)
  • Author(s): Kuwano Y, Adler M, Zhang H, Groisman A, Ley K
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Galphai2 and Galphai3 differentially regulate arrest and chemotaxis in neutrophils. (2013)
  • Author(s): Kuwano Y, Adler M, Zhang H, Groisman A, Ley K
  • Organizer: 15th International Congress of Immunology.
  • Place of Presentation: Milan, Italy
• [Presentation] Ultrasonographic features for the diagnosis of subcutaneous venous malformation (2012)
  • Author(s): Kuwano Y, Nanko H, Kubo M, Sato S
  • Organizer: 第10回日独皮膚科学会
  • Place of Presentation: 徳島
  • Year and Date: 2012-11-14
• [Book] Chapter 10 : Alopecia areata and chemokine, Handbook of hair in health and disease (2012)
  • Author(s): Yoshihiro Kuwano, 分担著 (Edited by V Preedy)
  • Publisher: Wageningen Academic Publishers
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/der/