| Project/Area Number |
24791206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
YOSHIMURA Yuko 金沢大学, 子どものこころの発達研究センター, 博士研究員 (70597070)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 聴覚誘発磁場 / 幼児 / 自閉症スペクトラム障害 |
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| Research Abstract |
Magnetoencephalography (MEG) is used to measure the auditory evoked magnetic field (AEF), which affects language-related performance. Using the child-customised MEG, we investigated the P50m bilaterally in 35 young children (3 to 7 years old) with autism spectrum disorder (ASD) and 35 typically developing (TD) children. The results showed that the ASD children exhibited significantly less left-hemispheric dominance in P50m intensity compared with the TD children. Furthermore, TD children showed that shorter P50m latency in both hemispheres was specifically correlated with higher language-related performance. However, the ASD children did not show any correlation with language-related performance; instead, increasing chronological age was a significant predictor of shorter P50m latency in the right hemisphere. Our results revealed an atypical brain maturation of the auditory cortex in young children with ASD, regardless of language development.
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