study about a novel elucidation of endoplasmic reticulum stress response on ischemia/reperfusion injury and liver regeneration after massive hepatectomy and living donor liver transplantation

• Project/Area Number: 24791426
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: MORI Hiroki 徳島大学, 大学病院, 助教 (70448330)
• Research Collaborator: ISHIBASHI Hiroki 徳島大学, 大学病院, 講師 (20314867) ; UTSUNOMIYA Tohru (IMURA Satoru) 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30304801) ; MORINE Yuji 徳島大学, 大学病院, 助教 (60398021)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大量肝切除 / 肝再生 / 小胞体ストレス応答

Research Abstract

It is important issue to overcome liver failure after extended hepatectomy (Hx) or living donor liver transplantation which is still serious problem. This time, we investigated the involvement of the endoplasmic reticulum stress response on liver regeneration, using 70% Hx model, postoperative liver regeneration model, and 90% Hx model, postoperative liver failure model. In 90% Hx model, mRNA of intrahepatic endoplasmic reticulum stress response related genes were time-dependently up-regulated up to maximum 6 times at 1, 3, 7, 14, 21 days after Hx. In addition, they were strongly expressed since the late phase after postoperative 7 days. In 70% Hx model, they were time-dependently up-regulated up to about 1.5 to 3 times but not strongly expressed in equivalent to liver failure model.

Research Products

• [Journal Article] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through the epigenetic regulation (2014)
  • Author(s): Mori H, Ishibashi H, Shimada M, Utsunomiya T, Asanoma M, Yamada S, Saito Y, Iwahashi S, Ikemoto T, Imura S, Morine Y
  • Journal Title: Hepatogastroenterology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats (2014)
  • Author(s): Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M
  • Journal Title: J Gastroenterol Volume: 49(4) Issue: 4 Pages: 692-701
  • DOI: 10.1007/s00535-013-0799-9
  • Peer Reviewed
• [Journal Article] Asanoma M. Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver (2014)
  • Author(s): Hanaoka J, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Sugimoto K, Saito Y, Yamada S
  • Journal Title: Hepatol Res Volume: 44(1) Issue: 1 Pages: 114-121
  • DOI: 10.1111/hepr.12097
  • Peer Reviewed
• [Journal Article] Iliopsoas Abscess in an Infant (2014)
  • Author(s): Ishibashi H, Oshio T, Sogami T, Nii A, Mori H, Yada K, Shimada M
  • Journal Title: J Med Invest Volume: 61 Pages: 213-216
  • NAID: 130004822711
  • Peer Reviewed
• [Journal Article] Dye-assisted lymphatic sparing laparoscopic Palomo varicocelectomy in children (2014)
  • Author(s): Ishibashi H, Mori H, Yada K, Shimada M, Sogami T, Nii A
  • Journal Title: J Med Invest Volume: 61 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Changes of immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto/TJ-48) in patients with advanced pancreatic cancer. (2013)
  • Author(s): Ikemoto T, Shimada M, Iwahashi S, Saito Y, Kanamoto M, Mori H, Morine Y, Imura S, Utsunomiya T.
  • Journal Title: Int J Clin Oncol. Volume: 19 Issue: 1 Pages: 81-86
  • DOI: 10.1007/s10147-013-0529-6
  • Peer Reviewed
• [Journal Article] CXC receptor 4 and stromal cell-derived factor 1 in primary tumors and liver metastases of colorectal cancer. (2013)
  • Author(s): Yamada S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y.
  • Journal Title: Journal of Surgical Research Volume: 187 Issue: 1 Pages: 107-112
  • DOI: 10.1016/j.jss.2013.10.030
  • Peer Reviewed
• [Journal Article] The TheraCyte device protects against islet allograft rejection in immunized hosts. (2013)
  • Author(s): Kumagai-BraeschM,JacobsonS,Mori H, Jia X, Takahashi T, Wernerson A, Flodstrom-Tullberg M, Tibell A.
  • Journal Title: Cell Transplant. Volume: 22 Issue: 7 Pages: 1137-1146
  • DOI: 10.3727/096368912x657486
  • Peer Reviewed
• [Journal Article] The protective effect of adipose-derived stem cells against liver injury by trophic molecules. (2013)
  • Author(s): Yu Saito
  • Journal Title: Journal of Surgical Research Volume: 180 Issue: 1 Pages: 162-168
  • DOI: 10.1016/j.jss.2012.10.009
  • Peer Reviewed
• [Journal Article] Significance of sonic hedgehog signaling after massive hepatectomy in a rat. (2013)
  • Author(s): Jun Hanaoka
  • Journal Title: Surgery Today Volume: 50 Issue: 3 Pages: 300-307
  • DOI: 10.1007/s00595-012-0248-z
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3-dioxygenase Affects the Aggressiveness of Intraductal Papillary Mucinous Neoplasms Through (2013)
  • Author(s): Ikemoto T et al
  • Journal Title: Pancreas Volume: Jan;42(1) Issue: 1 Pages: 130-134
  • DOI: 10.1097/mpa.0b013e3182575e4a
  • Peer Reviewed
• [Journal Article] The impact of pegylated-interferon α-2b on partial and massive hepatectomy model in rats (2012)
  • Author(s): Mori H, Shimada M, Ikegami T, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Hanaoka J, Iwahashi S, Saito Y, Asanoma M, Yamada S, Miyake H
  • Journal Title: Hepatogastroenterology Volume: 59 Pages: 2300-2304
  • Peer Reviewed
• [Journal Article] Impact of a new refrigerator on the preservation of hepatic grafts. (2012)
  • Author(s): Mami Kanamoto
  • Journal Title: Hepatology research Volume: 42 Issue: 8 Pages: 798-805
  • DOI: 10.1111/j.1872-034x.2012.00987.x
  • Peer Reviewed
• [Journal Article] Role of histone deacetylase expression in intrahepatic cholangiocarcinoma (2012)
  • Author(s): Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Miyake H
  • Journal Title: Surgery Volume: 151 Issue: 3 Pages: 412-419
  • DOI: 10.1016/j.surg.2011.07.038
  • Peer Reviewed
• [Journal Article] The Impact of Pegylated-Interferon alpha-2b on Partial and Massive Hepatectomy Model in Rats. (2012)
  • Author(s): Mori H et al
  • Journal Title: Hepatogastroenterology Volume: 59(119) Pages: 2300-2304
  • Peer Reviewed
• [Presentation] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation (2013)
  • Author(s): Mori H, Ishibashi H, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Yada K, Shimada M
  • Organizer: International Surgical Week (ISW 2013)
  • Place of Presentation: フィンランド(Helsinki Exhibition and Convention Centre)
• [Presentation] 膵・胆管合流異常症に対する長期経過中に胆道癌を合併した3 症例の検討 (2013)
  • Author(s): 森大樹, 島田光生, 石橋広樹, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: 宮崎県(シーガイアコンベンションセンター)
• [Presentation] 分子標薬的Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果 (2013)
  • Author(s): 森大樹, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 山田眞一郎, 淺野間理仁, 石川大地, 三宅秀則
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京都(京王プラザホテル)
• [Presentation] ラットの膵・胆管合流異常症モデルの意義と課題 (2013)
  • Author(s): 森大樹, 石橋広樹, 佐藤宏彦, 矢田圭吾, 島田光生
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京都(京王プラザホテル)
• [Presentation] 胆道癌発がんモデルの膵・胆管合流異常症での発がん特性の解析 (2013)
  • Author(s): 森大樹, 島田光生, 宇都宮徹, 石橋広樹, 佐藤宏彦, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 矢田圭吾, 淺野間理仁, 山田眞一郎, 石川大地, 三宅秀則
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡県(マリンメッセ福岡)
• [Presentation] 胆道癌発がんモデルの膵・胆管合流異常症での発がん特性の解析 (2013)
  • Author(s): 森大樹, 島田光生, 宇都宮徹, 石橋広樹, 佐藤宏彦, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 矢田圭吾, 淺野間理仁, 山田眞一郎, 石川大地, 三宅秀則
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: マリンメッセ福岡(福岡県)
• [Presentation] ラットの膵・胆管合流異常症モデルの意義と課題 (2013)
  • Author(s): 森大樹, 石橋広樹, 佐藤宏彦, 矢田圭吾, 島田光生
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 分子標薬的Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果 (2013)
  • Author(s): 森大樹, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 山田眞一郎, 淺野間理仁, 石川大地, 三宅秀則
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation. (2013)
  • Author(s): Mori H, Ishibashi H, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Yada K, Shimada M.
  • Organizer: International Surgical Week (ISW 2013)
  • Place of Presentation: Helsinki Exhibition and Convention Centre(フィンランド)
• [Presentation] Bevacizumab の小胞体ストレス応答を介した大量肝切除後肝機能障害改善・肝再生促進効果 (2012)
  • Author(s): 森大樹, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 浅野間理仁, 山田眞一郎, 石川大地, 三宅秀則
  • Organizer: 第19回外科侵襲とサイトカイン研究会
  • Place of Presentation: 兵庫県(ホテルオークラ神戸)
  • Year and Date: 2012-12-08
• [Presentation] 分子標的薬Bevacizumab の小胞体ストレス応答を介した肝切除後肝機能障害改善効果 (2012)
  • Author(s): 宮谷智彦, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 森大樹, 花岡潤, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎, 三宅秀則
  • Organizer: 日本消化器関連学会週間【第10回日本消化器外科学会】
  • Place of Presentation: 兵庫県(神戸国際会議場)
• [Presentation] Bevacizumab は小胞体ストレス応答を介して肝切除後肝機能障害を改善する (2012)
  • Author(s): 徳永卓哉, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 森大樹, 花岡潤, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎, 三宅秀則
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉県(幕張メッセ)
• [Presentation] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction. (2012)
  • Author(s): Mori H et al
  • Organizer: Digestive Disease Week (DDW)
  • Place of Presentation: San Diego Convention Center（アメリカ）
• [Presentation] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maliunction through both epigenetic and genetic pathway. (2012)
  • Author(s): Mori H et al
  • Organizer: 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA)
  • Place of Presentation: Palais des Congres（フランス）
• [Presentation] 膵・胆管合流異常症の胆道上皮は発癌ポテンシャルを有する (2012)
  • Author(s): 森大樹 他
  • Organizer: 第112回 日本外科学会定期学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] 膵・胆管合流異常症の胆道上皮における遺伝子異常からみた治療方針 (2012)
  • Author(s): 森大樹 他
  • Organizer: 第67回 日本消化器外科学会総会
  • Place of Presentation: 富山国際会議場（富山）
• [Presentation] Risk of carcinogenesis in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation. (2012)
  • Author(s): 森大樹 他
  • Organizer: 第71回 日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] 膵胆管合流異常症におけるepigenetic/genetic修飾を介した胆道癌発癌機構に関する検討 (2012)
  • Author(s): 森大樹 他
  • Organizer: 第50回 日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川）