| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This study was intended to establish a safe and efficient stimulation electrodes and stimulation method of intraoperative motor evoked potential (MEP) monitoring in neurosurgery. In this study, the rat brain injury model was established for in vivo assessment by brain cortical MEP stimulation. The four parameters of MEP stimulation, intensity of the stimulus, stimulation time, number and frequency were changed and examined. It was clarified that the damage of the brain was proportional to the total electric power amount applied on the brain. If the total amount of electric power is the same, the larger number of stimulus and stimulus intensity causes more damage on the brain compared to the stimulation time. It was also discovered that the MEP threshold tends larger in biphasic stimulation than monophasic stimulation. These findings will support a safer and more efficient intraoperative MEP monitoring in neurosurgery.
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