Analysis of the enhanced bone fudion effect of a new synthetic vitamin E in a rat spinal fusion model.

• Project/Area Number: 24791555
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Oita University
• Principal Investigator: MIYAZAKI Masashi 大分大学, 医学部, 講師 (30527742)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: BMP / ラット / 脊椎固定 / bisphophonate / Zoledronic acid / マイクロCT / ラット脊椎固定モデル / ラット大腿骨骨折モデル / 骨誘導能 / ビタミンＥ誘導体 / 骨融合

Outline of Final Research Achievements

We aimed to investigate the enhanced effect of bone morphogenetic
protein (BMP) and bisphophonate, the enhanced effect of a new synthetic vitamin E and recombinant human BMP-2in a rat spinal fusion model. The synergic effect of a carbon nanofiber and recombinant human BMP-2 The combination of rhBMP-2 and zoledronic acid administered systemically as a single dose at the optimal timewas efficacious in our rat spinal fusionmodel. Our resultssuggest that this combination facilitates spinal fusion and has potential clinical application.

Research Products

• [Journal Article] Manipulation of anabolic and catabolic responses with bone morphogenetic protein and zoledronic acid in a rat spinal fusion model. (2014)
  • Author(s): Kodera R, Miyazaki M,Yoshiiwa T, Kawano M, Kaku N, Tsumura H.
  • Journal Title: Bone Volume: 58 Pages: 26-32
  • Peer Reviewed