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neuroprotective effect of remote limb ischemic preconditioning

Research Project

Project/Area Number 24791596
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYamaguchi University

Principal Investigator

YAMASHITA Satoshi  山口大学, 医学部附属病院, 助教 (20610885)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords四肢虚血リモートプレコンディショニング / early phase / 脳 / 長期保護 / 中大脳動脈閉塞モデル(MCAO) / リモートプレコンディショニング / 四肢虚血 / MCAO / 長期間保護 / 虚血耐性 / ターニケット / レーザードップラー血流計 / 中大脳動脈閉塞
Outline of Final Research Achievements

Several studies have shown the beneficial effects of remote limb ischemic preconditioning (RLIP) on brain protection. But there have been few investigations that evaluated its long-term protective effects. The present study examined the neuroprotective effects of RLIP 7 days after reperfusion in a rat focal ischemic model.
there were no physiologically relevant differences among groups for the body weight and all monitored variables. RLIP reduced infarct size (176±79.1 mm3, 62.1±60.0 mm3 ; P=0.003). Neurological score was significantly better in the RLIP group than in the control group (12.2±5.2, 3.4±3.7 at 7 day of reperfusion ; P=0.002).
The present study demonstrates that RLIP induced by noninvasive tourniquet reduces ischemic injury in rats. The protective effects of early phased tolerance were sustained at 7 days. Since RLIP is simple and non-invasive, it has potential for clinical use.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 四肢虚血リモートプレコンディショニングによる脳保護効果の検討2015

    • Author(s)
      山下 理
    • Organizer
      第19回日本神経麻酔集中治療学会
    • Place of Presentation
      長良川国際会議場、じゅうろくプラザ(岐阜)
    • Year and Date
      2015-04-10 – 2015-04-11
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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