Examination of inner ears of mice using 7T MRI and molecular biologic analysis

Research Project

Project/Area Number	24791813
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	St. Marianna University School of Medicine
Principal Investigator	NAKAMURA Manabu 聖マリアンナ医科大学, 医学部, 助教 (60386969)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	MRI / 内リンパ水腫 / プロテオミクス
Outline of Final Research Achievements	Endolymphatic hydrops may be involved in the pathogenesis of Meniere's disease. However, the etiology remains to be clarified. Magnetic resonance imaging (MRI) facilitates visualization of the inner ear structure, and is useful for physiological and pharmacological evaluation. In this study, we conducted high-magnetic-field MRI in mice to visualize endolymphatic hydrops. An endolymphatic hydrop model, PhexHyp-Duk/Y mice, was used, as well as a 7T MRI device. Using the 7.05T MRI device, inner ear imaging was performed. In the PhexHyp-Duk/Y mice, the presence of endolymphatic hydrops was confirmed.

Report

(4 results)