| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
In this study, we evaluated the effectiveness of photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) and a 410-nm wavelength light emitting diode (LED) in vitro and in vivo for MRSA. We found that ALA-PDT with a 410-nm LED had an in vitro bactericidal effect on MRSA. An in vivo study, we demonstrated that protoporphyrin IX (PpIX) successfully accumulated in MRSA on the ulcer surface after intraperitoneal administration of 5-ALA to mice. Furthermore, we found that ALA-PDT accelerated wound healing and decreased the bacterial count on the ulcer surface. Our findings indicate that ALA-PDT may be a new treatment option for MRSA-infected wounds.
|
