ETS-GS, a Novel Vitamin E Derivative, can Reduce theCrush-Injury relatedDamages in a Rodent Model
| Project/Area Number |
24791937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | クラッシュ症候群 / 活性酸素 / 抗酸化療法 / 蛍光イメージング / 全身性炎症反応 / 生体イメージング / 外傷 |
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| Research Abstract |
The mechanisms of crush syndrome in which the local traumatic injuries affect distant organs remain unknown. The purposes of this research were to reveal the involvement of reactive oxygen species (ROS) in systemic inflammation association with distant organ injuries and to evaluate the effects of ETS-GS, a novel vitamin E derivative in a rat model.
The ETS-GS treatment ameliorated the survival in a rat model of crush syndrome. Serum levels of inflammatory cytokines and oxidative stress were significantly decreased in the ETS-GS group compared with those in the control group. Ex vivo imaging confirmed that ETS-GS treatment reduced ROS generation in both the lung and the muscle following crush injury. Administration of ETS-GS could reduce ROS generation, systemic inflammation, and distant organ damage and improve survival in a rat model of crush injury. These results suggest that ROS play an important role in the mechanisms of crush injury.
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Report
(3 results)
Research Products
(8 results)
