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ETS-GS, a Novel Vitamin E Derivative, can Reduce theCrush-Injury relatedDamages in a Rodent Model

Research Project

Project/Area Number 24791937
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

NAKAGAWA Junichiro  大阪大学, 医学部附属病院, 医員 (60597508)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsクラッシュ症候群 / 活性酸素 / 抗酸化療法 / 蛍光イメージング / 全身性炎症反応 / 生体イメージング / 外傷
Research Abstract

The mechanisms of crush syndrome in which the local traumatic injuries affect distant organs remain unknown. The purposes of this research were to reveal the involvement of reactive oxygen species (ROS) in systemic inflammation association with distant organ injuries and to evaluate the effects of ETS-GS, a novel vitamin E derivative in a rat model.
The ETS-GS treatment ameliorated the survival in a rat model of crush syndrome. Serum levels of inflammatory cytokines and oxidative stress were significantly decreased in the ETS-GS group compared with those in the control group. Ex vivo imaging confirmed that ETS-GS treatment reduced ROS generation in both the lung and the muscle following crush injury. Administration of ETS-GS could reduce ROS generation, systemic inflammation, and distant organ damage and improve survival in a rat model of crush injury. These results suggest that ROS play an important role in the mechanisms of crush injury.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2013 2012

All Presentation (8 results)

  • [Presentation] ETS-GS, a novel vitamin E derivative, can reduce the crush injury-related damages in a rodent model2013

    • Author(s)
      Junichiro Nakagawa
    • Organizer
      第7回 Asian Conference on Emergency Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] クラッシュ症候群における病態解明と新たな治療戦略2013

    • Author(s)
      中川 淳一郎
    • Organizer
      第27回日本外傷学会総会
    • Place of Presentation
      久留米
    • Year and Date
      2013-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ETS-GS, a Novel Vitamin E Derivative, Ameliorates Crush Syndrome in a Rodent model2013

    • Author(s)
      Junichiro Nakagawa
    • Organizer
      Society of Critical Care Medicine' s 42nd Critical Care congress
    • Place of Presentation
      San Juan
    • Year and Date
      2013-01-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ETS-GS, A NOVEL VITAMIN E DERIVATIVE, CAN REDUCE THE CRUSH INJURY-RELATED DAMAGES IN A RODENT MODEL2013

    • Author(s)
      Junichiro Nakagawa
    • Organizer
      The 7th Asian Conference on Emergency Medicine
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] クラッシュ症候群における病態解明と新たな治療戦略2013

    • Author(s)
      中川 淳一郎
    • Organizer
      第27回日本外傷学会
    • Place of Presentation
      久留米市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ETS-GS, a novel vitamin E derivative ameliorates crush syndrome in a rodent model.2013

    • Author(s)
      Junichiro Nakagawa
    • Organizer
      Society of Critical Care Medicine’s 42nd Critical Care conguress 20th
    • Place of Presentation
      San Juan, Puerto Rico
    • Related Report
      2012 Research-status Report
  • [Presentation] クラッシュ症候群における ETS-GS の治療効果に関する研究2012

    • Author(s)
      中川 淳一郎
    • Organizer
      第3回CIA研究会
    • Place of Presentation
      湯布院
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] クラッシュ症候群におけるETS-GSの治療効果に関する研究2012

    • Author(s)
      中川淳一郎
    • Organizer
      第3回CIA研究会
    • Place of Presentation
      湯布院、大分
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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