| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The purpose of this study is to investigate the effects of a treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human dental pulp cells, and elucidate of the mechanism of dentin regeneration.
In conclusion, our data show that a short-term treatment with TNF-alpha significantly increases the stem cell phenotype of DPCs as well as their function and multipotent differentiation ability. Additionally, our findings also demonstrate that the reprogramming depend on TNF-alpha specifically and NF-kB is not the only pathway involved in the TNF-alpha-enhanced stem cell phenotype of DPCs.
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