Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha
| Project/Area Number |
24792084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
UEDA Mayu 岡山大学, 大学病院, 医員 (20625719)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | TNF-α / 歯髄細胞 / 幹細胞化 |
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| Research Abstract |
The purpose of this study is to investigate the effects of a treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human dental pulp cells, and elucidate of the mechanism of dentin regeneration.
In conclusion, our data show that a short-term treatment with TNF-alpha significantly increases the stem cell phenotype of DPCs as well as their function and multipotent differentiation ability. Additionally, our findings also demonstrate that the reprogramming depend on TNF-alpha specifically and NF-kB is not the only pathway involved in the TNF-alpha-enhanced stem cell phenotype of DPCs.
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Report
(3 results)
Research Products
(12 results)
