Hydrothermal treatment of titanium implant surface with calcium promotes epithelial sealing
| Project/Area Number |
24792122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University (2013-2014)
Fukuoka Dental College (2012) |
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Principal Investigator |
YAMAZOE Jyunichi 九州大学, 歯学研究科(研究院), 研究員 (30452717)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | カルシウム水熱処理 / インプラント / 口腔インプラント / カルシウム修飾 / 水熱カルシウム処理 / チタン / 間葉系幹細胞 / チタン合金 / 水熱処理 / 骨伝導性 / 歯科インプラント |
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| Outline of Final Research Achievements |
Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. We aimed to investigate whether CaCl2 hydrothermal-treated (Ca-HT) Ti could promote sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with either Ca-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group) or non-treated implants (Cont group). We also investigated the effect of Ca-HT on the attachment of rat oral epithelial cells (OECs). OEC adherence on Ca-HT Ti plates was stronger, with greater expression levels of adhesion proteins, compared with Cont and DW-HT groups. These results indicated that HT with CaCl2 improved the integration of soft tissue cells with Ti, which may facilitate the development of a soft tissue barrier around the implant.
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Report
(4 results)
Research Products
(1 results)
