Development of a mandibular movement analytical technique using multi-section dynamic MRI and muscle MRI

• Project/Area Number: 24792140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kyoto University
• Principal Investigator: RYUSUKE Nakai 京都大学, 再生医科学研究所, 研究員 (10576234)
• Research Collaborator: WAKATSUKI Mariko
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: MRI / シミュレーション / 医工学 / 情報工学 / 生体力学 / 顎関節 / 顎運動 / 画像処理

Outline of Final Research Achievements

Using human high-field MR system, I acquired dynamic images of mandibular movement and various kinds of MR images of temporomandibular joints and masticatory muscles. In addition, I developed a new software which could analyze mandibular movement and extract motion trajectories using MR images automatically. As a result, the measurements of mandibular movement suggested that disorder in the articular disk was related to displacement in the LR direction. Also, subjects with large dislocation of the articular disk had a large difference in the masseter muscle between the right and left sides. Then, the automatic measurement technique had very good precision. This technique gives precise information that can facilitate diagnosis of temporomandibular joint disorder and mandibular movement disturbance. Furthermore, I performed the biomechanical analysis by FEM. As a result, it was revealed that the subjects with TMJ disorders had the element that was high in stress.

Research Products

• [Presentation] Automated analysis of three-dimensional mandibular movement using multi-section dynamic MRI. (2014)
  • Author(s): Nakai R, Azuma T, Shigeno K, Wakatsuki M, Liu G, Takizawa O, Iwata H
  • Organizer: Joint Annual Meeting ISMRM & ESMRMB 2014
  • Place of Presentation: Milan
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Development and evaluation of labeled islet cells using iron oxide nanoparticles and DNA hybridization. (2014)
  • Author(s): Nakai R, Kitamura N, Iwata H
  • Organizer: Joint Annual Meeting ISMRM & ESMRMB 2014
  • Place of Presentation: Milan
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Automated analysis of three-dimensional mandibular movement using multi-section dynamic MRI (2014)
  • Author(s): Ryusuke Nakai, Takashi Azuma, Keiji Shigeno, Mariko Wakatsuki, Guoxiang Liu, Osamu Takizawa, Hiroo Iwata
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: Milan, Italy
• [Presentation] Analysis of the relationship of mandibular movement with the condition of the masseter muscles and the temporomandibular joint using multi-section dynamic MRI and DTI and a T1, T2 map (2013)
  • Author(s): Ryusuke Nakai, Takashi Azuma, Keiji Shigeno, Osamu Takizawa, Hiroo Iwata
  • Organizer: ISMRM 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] 下顎運動の動的撮像データに対する処理手法の開発 (2013)
  • Author(s): 中井隆介、東 高志、茂野啓示、瀧澤 修、岩田博夫
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
• [Presentation] Analysis of the Relationship of Mandibular Movement with the Condition of the Masseter Muscles and the Temporomandibular Joint Using Multi-Section Dynamic MRI and DTI and a T1, T2 Map (2013)
  • Author(s): Ryusuke Nakai, Takashi Azuma, Keiji Shigeno, Osamu Takizawa, Hiroo Iwata
  • Organizer: ISMRM 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City, Utah, USA