Development of novel biomaterial using poly(P) and bFGF onto porous hydroxyl apatite
| Project/Area Number |
24792143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ｂFGF / 多孔性アパタイト / ポリリン酸 / bFGF / 骨増生 / インプラント / ハイドロキシアパタイト / ポリリン酸ナトリウム |
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| Research Abstract |
In difficult situation of bone augmentation such as horizontality bone regeneration, development of newly habrized biomaterials with bone formation promoting effective is demanded. we determined the optimum chain length of poly(P) binding to bFGF, we developed a composite of poly(P) and bFGF with IP-CHA as an innovative artificial bone for predictable bone regeneration. that in vitro study, poly(P) and bFGF promote osteoblast activities as interaction efforts. Also in vivo study, poly(P) and b FGF combined onto IP-CHA were established promoted bone formation.
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Report
(3 results)
Research Products
(2 results)
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[Presentation] Influence of formalin fixation on implant stability quotient and bone mechanical characteristics2012
Author(s)
Morita K, Doi k, Oue H, Kajihara S, Makihara Y, Hayashi K, Harada K, Matsuura A, Kubo T, Akagawa Y
Organizer
The 20th meeting of European Association For Osseointegration
Place of Presentation
Copenhagen, Denmark
Year and Date
2012-10-11
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