Basic study on the action mechanism of low-energy laser: Control of free radicals
| Project/Area Number |
24792150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
MORO YURIKO 奥羽大学, 歯学部, 助教 (90433549)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低出力レーザー / 血管内皮細胞 / フリーラジカル / In vitro / 炎症 / 活性酸素 / 一酸化窒素 |
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| Outline of Final Research Achievements |
To investigate the influence of low-energy laser on the free radical control system, dynamics of nitric oxide, reactive oxygen, reactive oxygen-scavenging enzyme, and nitrotyrosine in vascular endothelial cells were observed. Laser irradiation changed these free radical expressions, and the expression in the inflammatory state was different from that in the non-inflammatory state. It was suggested that low-energy laser influences free radical expression, contributing to the anti-inflammatory effect.
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Report
(5 results)
Research Products
(3 results)
