| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It is reported that FGF-2 which is an anti-ulcer drug causes a bone regeneration. We searched optimal condition of the murine alveolar bone regeneration in mouse by FGF -2. The controlled released 20 microgram FGF-2 using gelatin hydrogel occurred good bone regeneration. From histologic analysis, periosteum-related cortical bone addition was confirmed. Also, FGF-2 proliferated the osteoblasts which expressed the FGF receptor included in the periosteum and promoted a bone matrix production, and the additive bone regeneration to, as a result, existing bones was thought. Because a series of bone regeneration phenomena ended in four weeks, the possibility that the additive reproduction effect with repeated doses was obtained was suggested. Further analysis is expected.
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