Elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition mediated by DeltaNp63

• Project/Area Number: 24792231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: MATSUBARA Ryota 九州大学, 大学病院, 医員 (60615798)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ΔNp63 / 口腔扁平上皮癌 / 上皮ー間葉転換（EMT） / 浸潤・転移 / EMT / 癌幹細胞

Research Abstract

The purpose in this study is elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition (EMT) mediated by DeltaNp63.
As the results, It is suggested that DeltaNp63 downregulation induced EMT in oral squamous cell carcinoma. DeltaNp63 possibly involved in acquirement of the ability of the invasion, metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype.

Research Products

• [Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype (2014)
  • Author(s): Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinnno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Clinical and Experimental Metastasis Volume: 31(3) Pages: 293-306
  • Peer Reviewed
• [Journal Article] 頸部再発に対し放射線併用超選択的動注化学療法が奏功した舌扁平上皮癌の1例 (2014)
  • Author(s): 松原良太, 川野真太郎, 清島保, 平野充広, 丸瀬靖之, 中村誠司
  • Journal Title: 日本口腔外科学会雑誌 Volume: 60(2) Pages: 76-81
  • Peer Reviewed
• [Journal Article] Carcinoma ex pleomorphic adenoma of the upper lip : A case of an unusual malignant component of squamous cell carcinoma (2013)
  • Author(s): Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura
  • Journal Title: World Journal of Surgical Oncology Volume: 11(1) Pages: 234-234
  • Peer Reviewed
• [Journal Article] Anti-apoptotic role of sonic hedgehog signaling pathway in the proliferation of ameloblastoma (2013)
  • Author(s): Shiori Kanda, Takeshi Mitsuyasu, Yu Nakao, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamura
  • Journal Title: International Journal of Oncology Volume: 43(3) Pages: 695-702
  • Peer Reviewed
• [Journal Article] Parotid gland myoepithelioma with remarkable cystic formation : A case report (2013)
  • Author(s): Hiroe Kakehashi, Shintaro Kawano, Tamotsu Kiyoshima, Mayumi Shimizu, Masafumi Moriyama, Ryota Matsubara, Takahiro Kiyosue, Yuichi Goto, Hideki Shiratsuchi, Seiji Nakamura
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 25(2) Pages: 183-188
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma (2013)
  • Author(s): Takahiro Kiyosue, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinno, Takeshi Toyoshima, Ryoji Kitamura, Kazunari Oobu, Seiji Nakamura
  • Journal Title: International Journal of Clinical Oncology Volume: 18(1) Pages: 154-163
  • Peer Reviewed
• [Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype. (2013)
  • Author(s): Yuichi Goto, Shintaro Kawano, Ryota Matsubara , Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Clinical & Experimental Metastasis Volume: 31 Pages: 293-306
  • Peer Reviewed
• [Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma (2012)
  • Author(s): Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shinaro Kawano, Takahiro Kiyosue, Ryota Matsubara, Yuichi Goto, Mitsuhiro Hirano, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: 138(8) Pages: 1299-1310
  • Peer Reviewed
• [Journal Article] Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma (2012)
  • Author(s): Ryota Matsubara, Shintaro Kawano, Toru Chikui, Takahiro Kiyosue, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinno, Tetsuji Nagata, Kazunari Oobu, Koichiro Abe, Seiji Nakamura
  • Journal Title: Academic Radiology Volume: 19(6) Pages: 708-717
  • Peer Reviewed
• [Journal Article] Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma
  • Author(s): Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
  • Journal Title: Journal of Translational Medicine Volume: (in press)
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌における IL-6 の発現と機能~抗癌剤抵抗性獲得への関与について~ (2014)
  • Author(s): 神野哲平, 川野真太郎, 松原良太, 後藤雄一, 清島保, 丸瀬靖之, 神野彰子, 金子直樹, 坂本泰基, 橋口有真, 森山雅文, 大部一成, 杉浦剛, 中村誠司
  • Organizer: 第67回 NPO法人日本口腔科学会学術集会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-05-08
• [Presentation] 口腔扁平上皮癌における IL-6 の発現と臨床病理学的所見との関連 (2014)
  • Author(s): 神野哲平, 川野真太郎, 松原良太, 清末崇裕, 後藤雄一, 平野充広, 田中秀明, 丸瀬靖之, 今藤彰子, 森山雅文, 大部一成, 中村誠司
  • Organizer: 第32回 日本口腔腫瘍学会総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-01-24
• [Presentation] 口腔扁平上皮癌頸部転移に対する術後治療の有用性についての検討 (2014)
  • Author(s): 金子直樹, 大部一成, 後藤雄一, 川野真太郎, 橋口有真, 松原良太, 神野哲平, 丸瀬靖之, 坂本泰基, 田中秀明, 杉浦剛, 中村誠司
  • Organizer: 第32回 日本口腔腫瘍学会総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-01-24
• [Presentation] 唾液腺悪性腫瘍の臨床病理学的検討 (2014)
  • Author(s): 坂本泰基, 後藤雄一, 川野真太郎, 今藤彰子, 松原良太, 神野哲平, 丸瀬靖之, 金子直樹, 橋口有真, 大部一成, 杉浦剛, 中村誠司
  • Organizer: 第32回 日本口腔腫瘍学会総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-01-23
• [Presentation] 口腔扁平上皮癌におけるIL-6の発現と臨床病理学的所見との関連 (2014)
  • Author(s): 神野哲平、川野真太郎、松原良太、清末崇裕、後藤雄一、平野充広、田中秀明、丸瀬靖之、今藤彰子、森山雅文、大部一成、中村誠司
  • Organizer: 第32回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 北海道札幌市
• [Presentation] 上部消化管内視鏡検査にて重複癌を認めた口腔扁平上皮癌症例の検討 (2013)
  • Author(s): 松原良太, 川野真太郎, 清末崇裕, 北村亮二, 後藤雄一, 平野充広, 神野哲平, 大部一成, 杉浦剛, 中村誠司
  • Organizer: 第58回 日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2013-10-11
• [Presentation] 口腔扁平上皮癌高転移株より分離した上皮-間葉転換細胞の特性 (2013)
  • Author(s): 平野充広, 川野真太郎, 松原良太, 清末崇裕, 後藤雄一, 神野哲平, 丸瀬靖之, 豊嶋健史, 北村亮二, 田中秀明, 大部一成, 中村誠司
  • Organizer: 第17回 九州地区口腔癌研究会学術講演会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2013-06-07
• [Presentation] 口腔扁平上皮癌高転移株より分離した上皮-間葉転換細胞の特性 (2013)
  • Author(s): 平野充広、川野真太郎、松原良太、清末崇裕、後藤雄一、神野哲平、丸瀬靖之、豊嶋健史、北村亮二、田中秀明、大部一成、中村誠司
  • Organizer: 第17回九州地区口腔癌研究会
  • Place of Presentation: 福岡県福岡市
• [Presentation] 口腔扁平上皮癌におけるIL-6の発現と臨床病理学的所見との関連 (2013)
  • Author(s): 神野哲平、川野真太郎、松原良太、清末崇裕、後藤雄一、平野充広、田中秀明、丸瀬靖之、森山雅文、豊嶋健史、大部一成、中村誠司
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京都新宿区
• [Presentation] 口腔扁平上皮癌高転移株より分離した上皮-間葉転換細胞の特性 (2013)
  • Author(s): 平野充広、川野真太郎、松原良太、清末崇裕、後藤雄一、神野哲平、丸瀬靖之、豊嶋健史、北村亮二、田中秀明、大部一成、中村誠司
  • Organizer: 第17回 九州地区口腔癌研究会
  • Place of Presentation: 福岡県福岡市
• [Presentation] 口腔扁平上皮癌患者における術前血清CRP値の臨床的意義 (2012)
  • Author(s): 平野充広、川野真太郎、後藤雄一、松原良太、清末崇裕、北村亮二、神田詩織、村津大地、田中秀明、神野哲平、大部一成、中村誠司
  • Organizer: 第57回 日本口腔外科学会総会・学術大会
  • Place of Presentation: 神奈川県横浜市