| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Gastroesophageal Reflux (GER) is a disease featured by reflux of stomach contents into the esophagus, causing chest pain and nausea by stimulation to the esophagus. Its therapy is mainly performed by acid reducer. We focused on the vagal afferent pathway mediating visceral sensation to brain. First, we investigated whether experimental stimulation affect oral function involving salivation. Next, we investigated whether acid reducer affect salivation. The present study suggested that vagal afferent stimulation evoked salivation, but also a kind of acid reducer increased salivation evoked by vagal afferent stimulation. Therefore, it was suggested that visceral sensation related to oral function involving salivation.
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