Physiological study on oral function activated by visceral sensation: brain-gut model and PET imaging
| Project/Area Number |
24792299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
HIROTAKA Ueda 鹿児島大学, 医学部・歯学部附属病院, 助教 (10583445)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 唾液分泌 / 迷走神経 / 脳腸相関 / 唾液 / 自律神経 / 胃酸分泌抑制剤 / 迷走神経刺激 / パッチクランプ / 中枢投与 / 口腔乾燥症 / 電気生理学 |
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| Outline of Final Research Achievements |
Gastroesophageal Reflux (GER) is a disease featured by reflux of stomach contents into the esophagus, causing chest pain and nausea by stimulation to the esophagus. Its therapy is mainly performed by acid reducer. We focused on the vagal afferent pathway mediating visceral sensation to brain. First, we investigated whether experimental stimulation affect oral function involving salivation. Next, we investigated whether acid reducer affect salivation. The present study suggested that vagal afferent stimulation evoked salivation, but also a kind of acid reducer increased salivation evoked by vagal afferent stimulation. Therefore, it was suggested that visceral sensation related to oral function involving salivation.
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Report
(4 results)
Research Products
(17 results)
