| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The purpose of the present study was to investigate whether the cells derived from periodontal ligament have the ability to differentiate a vascular endothelial cell by FGF-2. The TesPDL3 cells were expressed KDR/Flk-1 that VEGF-A receptors using anti KDR/Flk-1 antibodies. After the TesPDL3 cells were cultured with FGF-2, all RNA were collected and measured by RT-PCR. Expression of vWF and KDR/Flk-1 were increased both. The TesPDL3 cells were cultured with VEGF-A and showed significant cell growth compared with other cells. The conclusion that the TesPDL3 cells may have the potential to differentiate into endothelial cells by FGF-2, and undifferentiated cells derived periodontal ligament able to differentiate into vascular endothelial-cell-like cells.
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