Fabrication of smart nanofiber mesh for removal of uremic toxins

• Project/Area Number: 24800085
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute for Materials Science
• Principal Investigator: NAMEKAWA Koki 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMSポスドク研究員 (60638568)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ナノファイバー / 血液浄化 / 尿毒素 / 電界紡糸法

Research Abstract

In this study, we develop a zeolite-polymer composite nanofiber mesh to remove uremic toxins for blood purification. The nanofiber is composed of blood compatible poly(ethylene-co-vinyl alcohol) (EVOH) as the primary matrix polymer and zeolites which are capable of selectively adsorbing uremic toxins such as creatinine.The composite fiber meshes were produced by a cost-effective electrospinning method: electrospinning composite solutions of EVOH and zeolites. The SEM/EDX images and thermogravimetry curves showed that over 90% of zeolites in the solution were successfully incorporated into the EVOH nanofibers. Although the barrier properties of the EVOH matrix lowered the creatinine adsorption capacity of the zeolites in the fiber when compared with adsorption to free zeolites, their adsorption capacity was still enough of the free zeolites. The proposed composite fibers have the potential to be utilized as a new approach to removing nitrogenous waste products from the bloodstream.

Research Products

• [Journal Article] Fabrication of zeolite- polymer composite nanofibers for removal of uremic toxins from kidney failure patients (2014)
  • Author(s): Koki Namekawa, Tokoro Makoto Schreiber, Takao Aoyagi, Mitsuhiro Ebara
  • Journal Title: Biomaterials Science Volume: 2 Pages: 674-679
• [Journal Article] Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients (2014)
  • Author(s): Koki Namekawa, Tokoro Makoto Schreiber, Takao Aoyagi, Mitsuhiro Ebara
  • Journal Title: Biomaterials Science Volume: 2 Issue: 5 Pages: 674-679
  • DOI: 10.1039/c3bm60263j
  • Peer Reviewed
• [Presentation] (2014)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: つくば医工連携フォーラム2014
  • Place of Presentation: つくば
  • Year and Date: 2014-01-28
• [Presentation] (2014)
  • Author(s): Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
  • Organizer: 2014 Annual Meeting & Exposition of the Society for Biomaterials
  • Place of Presentation: Denver, CO
• [Presentation] (2014)
  • Author(s): Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
  • Organizer: MANA International Symposium 2014
  • Place of Presentation: Tsukuba
• [Presentation] (2014)
  • Author(s): Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
  • Organizer: Trend in Nanotechnology Japan 2014
  • Place of Presentation: Tokyo
• [Presentation] 尿毒素を吸着するナノファイバーコンポジットの作製 (2014)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: つくば医工連携フォーラム2014
  • Place of Presentation: 産業技術総合研究所
• [Presentation] Electrospun zeolite composite nanofibers for the adsorption of uremic toxins (2014)
  • Author(s): Koki Namekawa, Makoto Tokoro Schreiber, Takao Aoyagi, Mitsuhiro Ebara
  • Organizer: Trend in NanoTechnology Japan 2014
  • Place of Presentation: Tokyo Big Sight
• [Presentation] Fabrication of zeolite-polymer composite nanofibers for the adsorption of uremic toxins (2014)
  • Author(s): Koki Namekawa, Makoto Tokoro Schreiber, Takao Aoyagi, Mitsuhiro Ebara
  • Organizer: MANA International Symposium 2014
  • Place of Presentation: Epochal Tsukuba
• [Presentation] Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients (2014)
  • Author(s): Koki Namekawa, Makoto Tokoro Schreiber, Mitsuhiro Ebara, Takao Aoyagi
  • Organizer: 2014 Annual Meeting & Exposition of the Society for Biomaterials
  • Place of Presentation: Colorado Convention Center, Denver, CO
• [Presentation] (2013)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: 第35回日本バイオマテリアル学会大会
  • Place of Presentation: 東京
• [Presentation] (2013)
  • Author(s): 滑川亘希、荏原充宏、青柳隆夫
  • Organizer: 第51回日本人工臓器学会
  • Place of Presentation: 横浜
• [Presentation] (2013)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢
• [Presentation] ゼオライト配合ナノファイバーコンポジットの作製と尿毒素吸着特性 (2013)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢大学
• [Presentation] 血液適合性を有する選択的毒素吸着型ナノファイバーの作製 (2013)
  • Author(s): 滑川亘希、荏原充宏、青柳隆夫
  • Organizer: 第51回日本人工臓器学会大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 尿毒素を吸着するナノファイバーメッシュの作製 (2013)
  • Author(s): 滑川亘希、所真人、荏原充宏、青柳隆夫
  • Organizer: 第35回日本バイオマテリアル学会大会
  • Place of Presentation: タワーホール船堀
• [Remarks] 独立行政法人物質・材料研究機構 生体機能材料ユニット 複合化生体材料グループホームページ
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/
• [Remarks] 物質・材料研究機構 複合化生体材料グループHP
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/
• [Patent(Industrial Property Rights)] 血液浄化用膜、血液浄化用膜の製造方 法及び透析装置 (2013)
  • Inventor(s): 荏原充宏、滑川亘希、青柳隆夫
  • Industrial Property Rights Holder: 物質・材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-174636
  • Filing Date: 2013-08-26
• [Patent(Industrial Property Rights)] 血液浄化用膜、血液浄化用膜の製造方法及び透析装置 (2013)
  • Inventor(s): 荏原充宏、滑川亘希、青柳隆夫
  • Industrial Property Rights Holder: 荏原充宏、滑川亘希、青柳隆夫
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-174636
  • Filing Date: 2013-08-26