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Fabrication of smart nanofiber mesh for removal of uremic toxins

Research Project

Project/Area Number 24800085
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute for Materials Science

Principal Investigator

NAMEKAWA Koki  独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMSポスドク研究員 (60638568)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsナノファイバー / 血液浄化 / 尿毒素 / 電界紡糸法
Research Abstract

In this study, we develop a zeolite-polymer composite nanofiber mesh to remove uremic toxins for blood purification. The nanofiber is composed of blood compatible poly(ethylene-co-vinyl alcohol) (EVOH) as the primary matrix polymer and zeolites which are capable of selectively adsorbing uremic toxins such as creatinine.The composite fiber meshes were produced by a cost-effective electrospinning method: electrospinning composite solutions of EVOH and zeolites. The SEM/EDX images and thermogravimetry curves showed that over 90% of zeolites in the solution were successfully incorporated into the EVOH nanofibers. Although the barrier properties of the EVOH matrix lowered the creatinine adsorption capacity of the zeolites in the fiber when compared with adsorption to free zeolites, their adsorption capacity was still enough of the free zeolites. The proposed composite fibers have the potential to be utilized as a new approach to removing nitrogenous waste products from the bloodstream.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (20 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (14 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Fabrication of zeolite- polymer composite nanofibers for removal of uremic toxins from kidney failure patients2014

    • Author(s)
      Koki Namekawa, Tokoro Makoto Schreiber, Takao Aoyagi, Mitsuhiro Ebara
    • Journal Title

      Biomaterials Science

      Volume: 2 Pages: 674-679

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients2014

    • Author(s)
      Koki Namekawa, Tokoro Makoto Schreiber, Takao Aoyagi, Mitsuhiro Ebara
    • Journal Title

      Biomaterials Science

      Volume: 2 Issue: 5 Pages: 674-679

    • DOI

      10.1039/c3bm60263j

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation]2014

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      つくば医工連携フォーラム2014
    • Place of Presentation
      つくば
    • Year and Date
      2014-01-28
    • Related Report
      2013 Final Research Report
  • [Presentation]2014

    • Author(s)
      Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
    • Organizer
      2014 Annual Meeting & Exposition of the Society for Biomaterials
    • Place of Presentation
      Denver, CO
    • Related Report
      2013 Final Research Report
  • [Presentation]2014

    • Author(s)
      Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
    • Organizer
      MANA International Symposium 2014
    • Place of Presentation
      Tsukuba
    • Related Report
      2013 Final Research Report
  • [Presentation]2014

    • Author(s)
      Koki Namekawa, Tokoro Makoto Schreiber, Mitsuhiro Ebara, Takao Aoyagi
    • Organizer
      Trend in Nanotechnology Japan 2014
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] 尿毒素を吸着するナノファイバーコンポジットの作製2014

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      つくば医工連携フォーラム2014
    • Place of Presentation
      産業技術総合研究所
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electrospun zeolite composite nanofibers for the adsorption of uremic toxins2014

    • Author(s)
      Koki Namekawa, Makoto Tokoro Schreiber, Takao Aoyagi, Mitsuhiro Ebara
    • Organizer
      Trend in NanoTechnology Japan 2014
    • Place of Presentation
      Tokyo Big Sight
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fabrication of zeolite-polymer composite nanofibers for the adsorption of uremic toxins2014

    • Author(s)
      Koki Namekawa, Makoto Tokoro Schreiber, Takao Aoyagi, Mitsuhiro Ebara
    • Organizer
      MANA International Symposium 2014
    • Place of Presentation
      Epochal Tsukuba
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients2014

    • Author(s)
      Koki Namekawa, Makoto Tokoro Schreiber, Mitsuhiro Ebara, Takao Aoyagi
    • Organizer
      2014 Annual Meeting & Exposition of the Society for Biomaterials
    • Place of Presentation
      Colorado Convention Center, Denver, CO
    • Related Report
      2013 Annual Research Report
  • [Presentation]2013

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      滑川亘希、荏原充宏、青柳隆夫
    • Organizer
      第51回日本人工臓器学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼオライト配合ナノファイバーコンポジットの作製と尿毒素吸着特性2013

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血液適合性を有する選択的毒素吸着型ナノファイバーの作製2013

    • Author(s)
      滑川亘希、荏原充宏、青柳隆夫
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 尿毒素を吸着するナノファイバーメッシュの作製2013

    • Author(s)
      滑川亘希、所真人、荏原充宏、青柳隆夫
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Remarks] 独立行政法人物質・材料研究機構 生体機能材料ユニット 複合化生体材料グループホームページ

    • URL

      http://www.nims.go.jp/bmc/group/smartbiomaterials/

    • Related Report
      2013 Final Research Report
  • [Remarks] 物質・材料研究機構 複合化生体材料グループHP

    • URL

      http://www.nims.go.jp/bmc/group/smartbiomaterials/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液浄化用膜、血液浄化用膜の製造方 法及び透析装置2013

    • Inventor(s)
      荏原充宏、滑川亘希、青柳隆夫
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-174636
    • Filing Date
      2013-08-26
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 血液浄化用膜、血液浄化用膜の製造方法及び透析装置2013

    • Inventor(s)
      荏原充宏、滑川亘希、青柳隆夫
    • Industrial Property Rights Holder
      荏原充宏、滑川亘希、青柳隆夫
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-174636
    • Filing Date
      2013-08-26
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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