| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In this study, we examined whether FGF-2 could induce vascular endothelial growth factor (VEGF)-A expression in periodontal ligament (PDL) cells and whether cell-to-cell interaction between PDL cells and endothelial cells (EC) could stimulate angiogenesis. FGF-2 induced VEGF-A expression from PDL cells. FGF-2 and VEGF-A synergistically stimulated the migration of PDL cells. Time-lapse analysis revealed that PDL cells migrated close to the tube-forming EC, mimicking pericytes. These findings suggest that FGF-2 and FGF-2-induced VEGF-A, as well as cell-to-cell interactions between PDL cells and EC, create a suitable environment of periodontal regeneration by orchestrating angiogenesis at FGF-2-applied sites.
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