BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)

• Project/Area Number: 24890180
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Sapporo Medical University
• Principal Investigator: KAWANO Yutaka 札幌医科大学, 医学部, 助教 (80398320)
• Project Period (FY): 2012 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: CD4調節性T細胞 / 慢性移植片対宿主病 / BH3プロファイリング / 調節性T細胞 / BH3 profiling

Research Abstract

BH3 profilings for CD4 positive regulatory (Treg) and non regulatory (Tcon) T cells were examined. Different priming between Treg and Tcon was associated to the effect of IL-2, especially on Treg, which contributes to cell survival. This profiling can explain how low dose IL-2 therapy works in patients with chronic graft-versus-host disease.

Research Products

• [Presentation] Low-dose-IL-2 induces Bcl2 expression and resistance to apoptosis in CD4 regulatory T cells. (2013)
  • Author(s): 村瀬和幸,河野豊, Jeremy Ryan ら
  • Organizer: アメリカ血液学会
  • Place of Presentation: ニューオーリンズ,アメリカ
  • Year and Date: 2013-12-09
• [Presentation] Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells (2013)
  • Author(s): 村瀬和幸，河野豊，Jeremy Ryanら
  • Organizer: アメリカ血液学会
  • Place of Presentation: ニューオーリンズ，アメリカ
• [Presentation] Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells (2012)
  • Author(s): 河野 豊，村瀬和幸，Ritz Jerome
  • Organizer: アメリカ血液学会
  • Place of Presentation: アトランタ，アメリカ