Elucidating the contribution of risk-perception and reward-value during optimal decision-making

• Project/Area Number: 24K18605
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Kindai University
• Principal Investigator: Chan Michele 近畿大学, 薬学部, 博士研究員 (40941092)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Decision-making

Outline of Research at the Start

Optimal decision-making results from the interplay and balance between risk and reward. However, patients with Generalised Anxiety Disorder over-focus on risk, resulting in impaired decision-making. In an animal model of anxiety, large-scale neuronal recording from the risk and reward pathways will be recorded from the Go-NoGo decision-making task. Later, the closed-loop system will be used to electrically stimulate these pathways in the brain to restore neural function.