シナプスにおける逆行性シグナルが生後発達期の機能的神経回路形成に果たす役割の解明

• Project/Area Number: 25000015
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: 狩野 方伸 東京大学, 医学系研究科, 教授 (40185963)
• Co-Investigator(Kenkyū-buntansha): 崎村 建司 (崎村 健司) 新潟大学, 脳研究所, 教授 (40162325) ; 少作 隆子 金沢大学, 保健学系, 教授 (60179025) ; 橋本 浩一 広島大学, 医歯薬保健学研究科, 教授 (00303272)
• Project Period (FY): 2013 – 2018
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥553,020,000 (Direct Cost: ¥425,400,000、Indirect Cost: ¥127,620,000); Fiscal Year 2017: ¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000); Fiscal Year 2016: ¥95,160,000 (Direct Cost: ¥73,200,000、Indirect Cost: ¥21,960,000); Fiscal Year 2015: ¥96,070,000 (Direct Cost: ¥73,900,000、Indirect Cost: ¥22,170,000); Fiscal Year 2014: ¥128,440,000 (Direct Cost: ¥98,800,000、Indirect Cost: ¥29,640,000); Fiscal Year 2013: ¥124,150,000 (Direct Cost: ¥95,500,000、Indirect Cost: ¥28,650,000)
• Keywords: シナプス / シナプス刈り込み / 生後発達 / 神経回路 / 逆行性シグナル / 小脳 / 登上線維 / マウス

Outline of Annual Research Achievements

平成29年度の計画全体としては、ほぼ計画通り順調に達成したが、平成29年7月に入手する予定であった遺伝子改変マウスの作製が想定以上に遅れ、2カ月遅れて平成29年9月にようやく入手できた。直ちにこの遺伝子改変マウスを交配して目的とする分子(IGF-1受容体を介するシグナルを抑制すると考えられる分子)のプルキンエ細胞特異的ノックアウトマウスの作出を開始したが、想定以上にマウスの妊娠率や出産率が悪く、平成29年度に計画していたシナプス刈り込みの機能解析実験に必要なプルキンエ細胞特異的ノックアウトマウスの個体数を得るのが困難になった。そこで十分な数のマウスを得るために、交配用のマウスの個体数を増やし、当初計画より繁殖期間を4ヶ月延長する必要が生じた(平成30年5月末まで)。さらにその後、このノックアウトマウスの機能解析と研究成果の取りまとめを行って、当初計画を終了するために、平成31年度に研究費を繰り越した。まず、生後20日から30日の当該分子のプルキンエ細胞特異的ノックアウトマウスから小脳スライスを作製し、プルキンエ細胞からホールセル記録を行った。登上線維を刺激した際に発生するシナプス応答から、プルキンエ細胞にシナプス結合する登上線維の本数を求め、さらにシナプス応答の振幅、およびキネティクスを解析した。その結果、登上線維シナプス刈り込みが障害されていることを確認した。以上の電気生理学的計測を終了し、データの取りまとめを行った。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. (2019)
  • Author(s): Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, Hashimoto K, Sakagami H, Kano M, Aiba A.
  • Journal Title: Scientific Reports Volume: Feb 26;9(1) Issue: 1 Pages: 2799-2799
  • DOI: 10.1038/s41598-019-38730-4
  • Peer Reviewed / Open Access
• [Journal Article] Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice (2018)
  • Author(s): Kikuchihara Saori、Sugio Shouta、Tanaka Kenji F.、Watanabe Takaki、Kano Masanobu、Yamazaki Yoshihiko、Watanabe Masahiko、Ikenaka Kazuhiro
  • Journal Title: Journal of Neurochemistry Volume: 147 Issue: 3 Pages: 344-360
  • DOI: 10.1111/jnc.14486
  • Peer Reviewed
• [Journal Article] Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output. (2018)
  • Author(s): Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
  • Journal Title: Cell Reports Volume: 25 Issue: 10 Pages: 2704-2715
  • DOI: 10.1016/j.celrep.2018.11.016
  • Peer Reviewed / Open Access
• [Journal Article] Monoacylglycerol lipase deficiency affects diet‐induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice (2018)
  • Author(s): Yoshida Kenji、Kita Yoshihiro、Tokuoka Suzumi M.、Hamano Fumie、Yamazaki Maya、Sakimura Kenji、Kano Masanobu、Shimizu Takao
  • Journal Title: The FASEB Journal Volume: 33 Issue: 2 Pages: 2484-2497
  • DOI: 10.1096/fj.201801203r
  • Peer Reviewed
• [Journal Article] Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling (2018)
  • Author(s): Sugaya Yuki, Kano Masanobu
  • Journal Title: Cellular and Molecular Life Sciences Volume: 75 Issue: 15 Pages: 2793-2811
  • DOI: 10.1007/s00018-018-2834-8
  • Peer Reviewed
• [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum (2018)
  • Author(s): Kano Masanobu、Watanabe Takaki、Uesaka Naofumi、Watanabe Masahiko
  • Journal Title: The Cerebellum Volume: 17 Issue: 6 Pages: 722-734
  • DOI: 10.1007/s12311-018-0964-z
  • Peer Reviewed
• [Journal Article] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. (2018)
  • Author(s): Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
  • Journal Title: Science Volume: 359 Issue: 6376 Pages: 679-684
  • DOI: 10.1126/science.aaq1144
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum (2018)
  • Author(s): Uesaka Naofumi、Abe Manabu、Konno Kohtarou、Yamazaki Maya、Sakoori Kazuto、Watanabe Takaki、Kao Tzu-Huei、Mikuni Takayasu、Watanabe Masahiko、Sakimura Kenji、Kano Masanobu
  • Journal Title: Neuron Volume: 97 Issue: 4 Pages: 796-805
  • DOI: 10.1016/j.neuron.2018.01.018
  • Peer Reviewed / Open Access
• [Journal Article] Presynaptic mechanisms mediating retrograde semaphorin signals for climbing fiber synapse elimination during postnatal cerebellar development. (2018)
  • Author(s): Uesaka N, Kano M
  • Journal Title: Cerebellum Volume: 17 Issue: 1 Pages: 17-22
  • DOI: 10.1007/s12311-017-0888-z
  • Peer Reviewed
• [Journal Article] Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. (2018)
  • Author(s): Hirai H, Kano M.
  • Journal Title: Curr Opin Pharmacol Volume: 38 Pages: 51-58
  • DOI: 10.1016/j.coph.2018.02.002
  • Peer Reviewed
• [Journal Article] PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. (2018)
  • Author(s): Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CL, Long JJ, Chen RC, Li LX, Yin LP, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ.
  • Journal Title: Cell Res. Volume: 28 Issue: 1 Pages: 90-110
  • DOI: 10.1038/cr.2017.128
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. (2018)
  • Author(s): Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
  • Journal Title: Neurochem Int Volume: S0197-0186 Issue: 17 Pages: 30442-4
  • DOI: 10.1016/j.neuint.2018.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Input-specific NMDAR-Dcpendent potentiation of dendritic GABAergic inhibition. (2018)
  • Author(s): Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ.
  • Journal Title: Ncuron. Volume: 97 Issue: 2 Pages: 368-377
  • DOI: 10.1016/j.neuron.2017.12.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis (2018)
  • Author(s): Nagahashi Masayuki、Yamada Akimitsu、Katsuta Eriko、Aoyagi Tomoyoshi、Huang Wei-Ching、Terracina Krista P.、Hait Nitai C.、Allegood Jeremy C.、Tsuchida Junko、Yuza Kizuki、Nakajima Masato、Abe Manabu、Sakimura Kenji、Milstien Sheldon、Wakai Toshifumi、Spiegel Sarah、Takabe Kazuaki
  • Journal Title: Cancer Research Volume: 78 Issue: 7 Pages: 1713-1725
  • DOI: 10.1158/0008-5472.can-17-1423
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7?Null Mouse Cornea (2018)
  • Author(s): Littlechild Stacy L.、Young Robert D.、Caterson Bruce、Yoshida Hideyuki、Yamazaki Maya、Sakimura Kenji、Quantock Andrew J.、Akama Tomoya O.
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 3 Pages: 1641-1641
  • DOI: 10.1167/iovs.17-22716
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. (2017)
  • Author(s): Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T.
  • Journal Title: Sci Adv. Volume: 3(6) Issue: 6
  • DOI: 10.1126/sciadv.1603001
  • Peer Reviewed / Open Access
• [Journal Article] Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. (2017)
  • Author(s): Miyazaki T, Yamasaki M, Hashimoto K, Kohda K, Yuzaki M, Shimamoto K, Tanaka K, Kano M, Watanabe M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 114(28) Issue: 28 Pages: 7438-7443
  • DOI: 10.1073/pnas.1617330114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice. (2017)
  • Author(s): Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H, Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K.
  • Journal Title: Hum Mol Genet. Volume: 26(16) Pages: 3094-3104
  • DOI: 10.1093/hmg/ddx193
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. (2017)
  • Author(s): Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M.
  • Journal Title: Nat Commun. Volume: 8(1) Issue: 1 Pages: 195-195
  • DOI: 10.1038/s41467-017-00260-w
  • Peer Reviewed / Open Access
• [Journal Article] Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network. (2017)
  • Author(s): Good JM, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M.
  • Journal Title: Cell Rep. Volume: 21(8) Issue: 8 Pages: 2066-2073
  • DOI: 10.1016/j.celrep.2017.10.101
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease (2017)
  • Author(s): Kano Masanobu、Watanabe Takaki
  • Journal Title: F1000Research Volume: 6 Pages: 416-416
  • DOI: 10.12688/f1000research.10485.1
  • Peer Reviewed / Open Access
• [Journal Article] The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells (2017)
  • Author(s): Rubio Mar?a E.、Matsui Ko、Fukazawa Yugo、Kamasawa Naomi、Harada Harumi、Itakura Makoto、Moln?r Elek、Abe Manabu、Sakimura Kenji、Shigemoto Ryuichi
  • Journal Title: Brain Structure and Function Volume: 222 Issue: 8 Pages: 3375-3393
  • DOI: 10.1007/s00429-017-1408-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7 (2017)
  • Author(s): Koike Masato、Shibata Masahiro、Sunabori Takehiko、Yamaguchi Junji、Sakimura Kenji、Komatsu Masaaki、Tanaka Keiji、Uchiyama Yasuo
  • Journal Title: The American Journal of Pathology Volume: 187 Issue: 7 Pages: 1586-1600
  • DOI: 10.1016/j.ajpath.2017.02.020
  • Peer Reviewed
• [Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. (2017)
  • Author(s): Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
  • Journal Title: Autophagy Volume: 17 Issue: 5 Pages: 1-14
  • DOI: 10.1080/15548627.2017.1314897
  • NAID: 120006881392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production (2017)
  • Author(s): Kawai Takafumi、Okochi Yoshifumi、Ozaki Tomohiko、Imura Yoshio、Koizumi Schuichi、Yamazaki Maya、Abe Manabu、Sakimura Kenji、Yamashita Toshihide、Okamura Yasushi
  • Journal Title: Journal of Neurochemistry Volume: 142 Issue: 5 Pages: 686-699
  • DOI: 10.1111/jnc.14106
  • Peer Reviewed / Open Access
• [Journal Article] Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1 (2017)
  • Author(s): Mashud Rana、Nomachi Akira、Hayakawa Akihide、Kubouchi Koji、Danno Sally、Hirata Takako、Matsuo Kazuhiko、Nakayama Takashi、Satoh Ryosuke、Sugiura Reiko、Abe Manabu、Sakimura Kenji、Wakana Shigeharu、Ohsaki Hiroyuki、Kamoshida Shingo、Mukai Hideyuki
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 7663-7663
  • DOI: 10.1038/s41598-017-07936-9
  • NAID: 120006366660
  • Peer Reviewed / Open Access
• [Journal Article] Drebrin E regulates neuroblast proliferation and chain migration in the adult brain. (2017)
  • Author(s): Kajita Y, Kojima N, Koganezawa N, Yamazaki H, Sakimura K, Shirao T.
  • Journal Title: Eur J Neurosci Volume: 46(6) Issue: 6 Pages: 2214-2228
  • DOI: 10.1111/ejn.13668
  • Peer Reviewed / Open Access
• [Journal Article] Netrin-1 Derived from the Ventricular Zone, but not the Floor Plate, Directs Hindbrain Commissural Axons to the Ventral Midline (2017)
  • Author(s): Yamauchi Kenta、Yamazaki Maya、Abe Manabu、Sakimura Kenji、Lickert Heiko、Kawasaki Takahiko、Murakami Fujio、Hirata Tatsumi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 11992-11992
  • DOI: 10.1038/s41598-017-12269-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbpl haploinsufficiency. (2017)
  • Author(s): Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, Suzuki T, Tatsukawa T, Itohara S, Sakimura K, Yamakawa K.
  • Journal Title: Hum Mol Genet. Volume: 26 Pages: 4961-4974
  • Peer Reviewed / Open Access
• [Journal Article] An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling (2017)
  • Author(s): Hayakawa-Yano Yoshika、Suyama Satoshi、Nogami Masahiro、Yugami Masato、Koya Ikuko、Furukawa Takako、Zhou Li、Abe Manabu、Sakimura Kenji、Takebayashi Hirohide、Nakanishi Atsushi、Okano Hideyuki、Yano Masato
  • Journal Title: Genes & Development Volume: 31 Issue: 18 Pages: 1910-1925
  • DOI: 10.1101/gad.300822.117
  • Peer Reviewed / Open Access
• [Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex (2017)
  • Author(s): Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12646-12646
  • DOI: 10.1038/s41598-017-04007-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1) (2017)
  • Author(s): Kawai Takafumi、Tatsumi Shoki、Kihara Shinji、Sakimura Kenji、Okamura Yasushi
  • Journal Title: Channels (Austin) Volume: 12 Issue: 1 Pages: 1-8
  • DOI: 10.1080/19336950.2017.1385684
  • Peer Reviewed / Open Access
• [Journal Article] Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity (2017)
  • Author(s): Honda Atsuko、Usui Hiroshi、Sakimura Kenji、Igarashi Michihiro
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 51 Pages: 20936-20946
  • DOI: 10.1074/jbc.m117.809541
  • Peer Reviewed / Open Access
• [Journal Article] Orexin modulates behavioral fear expression through the locus coeruleus (2017)
  • Author(s): Soya Shingo、Takahashi Tohru M.、McHugh Thomas J.、Maejima Takashi、Herlitze Stefan、Abe Manabu、Sakimura Kenji、Sakurai Takeshi
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1606-1606
  • DOI: 10.1038/s41467-017-01782-z
  • NAID: 120007128779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RNG105/Caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation (2017)
  • Author(s): Kei Nakayama, Rie Ohashi, Yo Shinoda, Maya Yamazaki, Manabu Abe, Akihiro Fujikawa, Shuji Shigenobu, Akira Futatsugi, Masaharu Noda, Katsuhiko Mikoshiba, Teiichi Furuichi, Kenji Sakimura, and Nobuyuki Shiina
  • Journal Title: eLife Volume: 6 Pages: 1-32
  • DOI: 10.7554/elife.29677
  • Peer Reviewed / Open Access
• [Journal Article] Protocadherin-αC2 is required for diffuse projections of serotonergic axons (2017)
  • Author(s): Katori Shota、Noguchi-Katori Yukiko、Okayama Atsushi、Kawamura Yoshimi、Luo Wenshu、Sakimura Kenji、Hirabayashi Takahiro、Iwasato Takuji、Yagi Takeshi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 15908-15908
  • DOI: 10.1038/s41598-017-16120-y
  • Peer Reviewed / Open Access
• [Journal Article] Corrigendum: Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. (2017)
  • Author(s): Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J.
  • Journal Title: Front Behav Neurosci. Volume: 11 Pages: 242-242
  • DOI: 10.3389/fnbeh.2017.00242
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma dell. (2017)
  • Author(s): Sugimoto N, Ishibashi H, Nakamura H, Yachie A, Ohno-Shosaku Takako.
  • Journal Title: Oncology Report Volume: 38(6) Pages: 3702-3708
  • DOI: 10.3892/or.2017.6048
  • Peer Reviewed / Open Access
• [Journal Article] YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation. (2017)
  • Author(s): Shimizu T, Osanai Y, Tanaka KF, Abe M, Natsume R, Sakimura K, Ikenaka K.
  • Journal Title: Glia Volume: 65 Issue: 2 Pages: 360-374
  • DOI: 10.1002/glia.23096
  • Peer Reviewed
• [Journal Article] Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors. (2017)
  • Author(s): Garcia-Hernandez S, Abe M, Sakimura K, Rubio ME.
  • Journal Title: Hear Res. Volume: 344 Pages: 284-294
  • DOI: 10.1016/j.heares.2016.12.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. (2017)
  • Author(s): Yoneda M, Sugimoto N, Katakura M, Matsuzaki K, Tanigami H, Yachie A, Ohno-Shosaku T, Shido O.
  • Journal Title: J Nutr Biochem. Volume: 39 Pages: 110-116
  • DOI: 10.1016/j.jnutbio.2016.10.002
  • NAID: 120005895700
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SCN5A(K817E), a novel Brugada syndrome-associated mutation that alters the activation gating of NaV1.5 channel (2016)
  • Author(s): Kinoshita K, Takahashi H, Hata Y, Nishide K, Kato M, Fujita H, Yoshida S, Murai K, Mizumaki K, Nishida K, Yamaguchi Y, Kano M, Tabata T, Nishida N
  • Journal Title: Heart Rhythm Volume: 13 Issue: 5 Pages: 1113-1120
  • DOI: 10.1016/j.hrthm.2016.01.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trans-synaptic modulation of kainate receptor functions by C1q-like proteins. (2016)
  • Author(s): Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.
  • Journal Title: Neuron Volume: in press Issue: 4 Pages: 752-767
  • DOI: 10.1016/j.neuron.2016.04.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive. (2016)
  • Author(s): Matsumoto-Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M., Kano, M., Sakimura, K., Hashimoto, K.
  • Journal Title: Cell Reports Volume: 16 Issue: 4 Pages: 994-1004
  • DOI: 10.1016/j.celrep.2016.06.053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crucial roles of the endocannabinoid 2-arachidonoylglycerol in the suppression of epileptic seizures. (2016)
  • Author(s): Sugaya Y, Yamazaki M, Uchigashima M, Kobayashi K, Watanabe M, Sakimura K, Kano M
  • Journal Title: Cell Rep Volume: 16 Issue: 5 Pages: 1405-15
  • DOI: 10.1016/j.celrep.2016.06.083
  • Peer Reviewed / Open Access
• [Journal Article] The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus (2016)
  • Author(s): Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata and Masanobu Kano
  • Journal Title: Neuron Volume: 91 Issue: 5 Pages: 1097-1109
  • DOI: 10.1016/j.neuron.2016.07.035
  • Peer Reviewed / Open Access
• [Journal Article] Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum. (2016)
  • Author(s): Dhar M, Brenner JM, Sakimura K, Kano M, Nishiyama H.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 12938-12938
  • DOI: 10.1038/ncomms12938
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition promotes long-term potentiation at cerebellar excitatory synapses. (2016)
  • Author(s): Binda F, Dorgans K, Reibel S, Sakimura K, Kano M, Poulain B, Isope P
  • Journal Title: Sci Rep Volume: 6 Issue: 1
  • DOI: 10.1038/srep33561
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. (2016)
  • Author(s): Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J.
  • Journal Title: Front Behav Neurosci. Volume: 10 Pages: 214-214
  • DOI: 10.3389/fnbeh.2016.00214
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area. (2016)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M
  • Journal Title: J Neurosci Volume: 36 Issue: 15 Pages: 4296-4312
  • DOI: 10.1523/jneurosci.4178-15.2016
  • NAID: 120005849916
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] GluD2 endows parallel fiber-Purkinje cell synapses with a high regenerative capacity. (2016)
  • Author(s): Ichikawa R, Sakimura K, Watanabe M
  • Journal Title: J Neurosci, Volume: 36 Issue: 17 Pages: 4846-4858
  • DOI: 10.1523/jneurosci.0161-16.2016
  • NAID: 120005853072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Doublet 7 shortening, doublet 5-preferential poly-Glu reduction, and beating stall of sperm flagella in Ttll9-/- mice. (2016)
  • Author(s): Konno A, Ikegami K, Konishi Y, Yang HJ, Abe M, Yamazaki M, Sakimura K, Yao I, Shiba K, Inaba K, Setou M.
  • Journal Title: J Cell Sci. Volume: 129 Issue: 14 Pages: 2757-2766
  • DOI: 10.1242/jcs.185983
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. (2016)
  • Author(s): Yang CC, Suzuki M, Yamakawa S, Uno S, Ishii A, Yamazaki S, Fukatsu R, Fujisawa R, Sakimura K, Tsurimoto T, Masai H.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 12135-12135
  • DOI: 10.1038/ncomms12135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. (2016)
  • Author(s): Mochida, S.*, Hida, Y., Tanifuji, S., Hagiwara, A., Hamada, S., Abe, M., Huan, M., Yasumura, M., Kitajima, I., Sakimura, K., Ohtsuka, T*.
  • Journal Title: Cell Reports Volume: 16 Issue: 11 Pages: 2901-2913
  • DOI: 10.1016/j.celrep.2016.08.020
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse (2016)
  • Author(s): Kono J,:Konno K, Talukder AH, Fuse T, Abe M, Uchida K, Horio S, Sakimura K, Watanabe M, Itoi K
  • Journal Title: Brain Struc Funct Volume: Epub ahead of print Issue: 1 Pages: 1-28
  • DOI: 10.1007/s00429-016-1303-0
  • Peer Reviewed / Open Access
• [Journal Article] SCOP/PHLPP1β mediates circadian regulation of long-term recongnition memory. (2016)
  • Author(s): Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Shigeki Shimba, Maya Yamazaki, Kenji Sakimura and Yoshitaka Fukada.
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 12926-12926
  • DOI: 10.1038/ncomms12926
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality. (2016)
  • Author(s): Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MI, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.
  • Journal Title: Neurobiol Dis. Volume: 96 Pages: 271-283
  • DOI: 10.1016/j.nbd.2016.09.016
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. (2016)
  • Author(s): Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S.
  • Journal Title: eNeuro. Volume: 3 Issue: 5 Pages: 0110-16
  • DOI: 10.1523/eneuro.0110-16.2016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forward-genetics analysis of sleep in randomly mutagenized mice (2016)
  • Author(s): Funato H and Yanagisawa M et al.
  • Journal Title: Nature Volume: 539(7629) Issue: 46 Pages: 378-383
  • DOI: 10.1038/nature20142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Roles of Cbln1 in Non-Motor Functions of Mice (2016)
  • Author(s): Otsuka S, Konno K, Abe M, Motohashi J, Kohda K, Sakimura K, Watanabe M, Yuzaki M
  • Journal Title: Journal of Neuroscience Volume: 36 Issue: 46 Pages: 11801-11816
  • DOI: 10.1523/jneurosci.0322-16.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Electrophysiological evidence showing muscarinic agonist-antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons. (2016)
  • Author(s): Sugawara Y, Kikuchi Y, Yoneda M, Ohno-Shosaku T
  • Journal Title: Brain Res Volume: 1642 Pages: 255-262
  • DOI: 10.1016/j.brainres.2016.03.054
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. (2016)
  • Author(s): Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
  • Journal Title: Cell Reports Volume: 17 Issue: 8 Pages: 2004-2014
  • DOI: 10.1016/j.celrep.2016.10.073
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] LTD-like molecular pathways in developmental synaptic pruning. (2016)
  • Author(s): Piochon C, Kano M, Hansel C
  • Journal Title: Nat Neurosci Volume: 19 Issue: 10 Pages: 1299-1310
  • DOI: 10.1038/nn.4389
  • Peer Reviewed / Open Access
• [Journal Article] 生後発達期の小脳におけるシナプス刈り込みのメカニズム (2016)
  • Author(s): 渡邉貴樹、上阪直史、狩野方伸
  • Journal Title: 生化学 Volume: 88 Pages: 621-629
  • NAID: 40020998193
• [Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
  • Journal Title: Nat Communications Volume: 7 Issue: 1 Pages: 10594
  • DOI: 10.1038/ncomms10594
  • NAID: 120006535052
  • URL: https://tokushima-u.repo.nii.ac.jp/records/2005585
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. (2016)
  • Author(s): Ly R, Bouvier G, Szapiro G, Prosser H, Randa11 AD, Kano M, Sakimura K, Isope P, Barbour BJ, Feltz A
  • Journal Title: J Physiol (Lond) Volume: 594 Issue: 4 Pages: 915-936
  • DOI: 10.1113/jp271623
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination (2016)
  • Author(s): Ichikawa R, Hashimoto K, Miyazaki T, Uchigashima M, Yamasaki M, Aiba A, Kano M, Watanabe M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 113 (8) Issue: 8 Pages: 2282-7
  • DOI: 10.1073/pnas.1511513113
  • NAID: 120005828473
  • Peer Reviewed / Open Access
• [Journal Article] Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice. (2015)
  • Author(s): Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Gotz M, Hirase H, Tanaka K.
  • Journal Title: Neuropsychopharmacology Volume: in press Issue: 7 Pages: 1660-1660
  • DOI: 10.1038/npp.2015.26
  • Peer Reviewed / Open Access
• [Journal Article] Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. (2015)
  • Author(s): Kishimoto Y, Cagniard B, Yamazaki M, Nakayama J, Sakimura K, Kirino Y, Kano M.
  • Journal Title: Front. Behav. Neurosci. Volume: 9 Pages: 134-134
  • DOI: 10.3389/fnbeh.2015.00134
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Implicit memory in monkeys: Development of a delay eyeblink conditioning system with parallel electromyographic and high-speed video measurements. (2015)
  • Author(s): Kishimoto Y, Yamamoto S, Suzuki K, Toyoda H, Kano M, Tsukada H, Kirino Y
  • Journal Title: PloS one Volume: 10 Issue: 6 Pages: e0129828-e0129828
  • DOI: 10.1371/journal.pone.0129828
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2 (2015)
  • Author(s): Yoshihiro Kita, Kenij Yoshida, Suzumi M. Tokuoka, Fumie Hamano, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Takao Shimizu
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0133663-e0133663
  • DOI: 10.1371/journal.pone.0133663
  • Peer Reviewed / Open Access
• [Journal Article] Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy (2015)
  • Author(s): Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T, Watanabe M
  • Journal Title: Nat Rev Neurosci Volume: 16 Issue: 5 Pages: 264-277
  • DOI: 10.1038/nrn3937
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Consensus Paper: Cerebellar Development (2015)
  • Author(s): Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T
  • Journal Title: Cerebellum Volume: online Issue: 6 Pages: 789-828
  • DOI: 10.1007/s12311-015-0724-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 発達期におけるシナプス刈り込みと逆行性シグナル (2015)
  • Author(s): 上阪直史、狩野方伸
  • Journal Title: 実験医学 Volume: 33 Pages: 1386-1370
• [Journal Article] Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. (2015)
  • Author(s): Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, Bito H
  • Journal Title: Nat Methods Volume: 12 Issue: 1 Pages: 64-70
  • DOI: 10.1038/nmeth.3185
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Structure-Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum. (2015)
  • Author(s): Tsutsumi S, Yamazaki M, Miyazaki T, Watanabe M, Sakimura K, Kano M, Kitamura K
  • Journal Title: J Neurosci. Volume: 35(2) Issue: 2 Pages: 843-52
  • DOI: 10.1523/jneurosci.2170-14.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Retrograde signaling for climbing fiber synapse elimination. (2015)
  • Author(s): Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M
  • Journal Title: Cerebellum Volume: 14 Issue: 1 Pages: 4-7
  • DOI: 10.1007/s12311-014-0615-y
  • Peer Reviewed
• [Journal Article] 内因性カンナビノイドによるシナプス伝達調節 (2015)
  • Author(s): 狩野方伸
  • Journal Title: お茶の水醫學雑誌 Volume: 63 Pages: 53-65
• [Journal Article] A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo. (2014)
  • Author(s): Tada M, Takeuchi A, Hashizume M, Kitamura K, Kano M
  • Journal Title: Eur J Neurosci Volume: (in press) Issue: 11 Pages: 1720-1728
  • DOI: 10.1111/ejn.12476
  • Peer Reviewed
• [Journal Article] Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis and neurodegenerative diseases (2014)
  • Author(s): Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A
  • Journal Title: Cell Reports Volume: 7 Issue: 5 Pages: 1626-1639
  • DOI: 10.1016/j.celrep.2014.04.048
  • Peer Reviewed / Open Access
• [Journal Article] Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain (2014)
  • Author(s): Uesaka N, Uchigashima,M, Mikuni T, Nakazawa T, Nakao H, Hirai K, Aiba A, Watanabe M, Kano M
  • Journal Title: Science Volume: 344 Issue: 6187 Pages: 1020-1023
  • DOI: 10.1126/science.1252514
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol (2014)
  • Author(s): Petrenko A B, Yamazaki M, Sakimura K, Kano M, Baba H
  • Journal Title: Behav Brain Res Volume: 271 Pages: 51-58
  • DOI: 10.1016/j.bbr.2014.05.063
  • Peer Reviewed
• [Journal Article] Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination. (2014)
  • Author(s): Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hashimoto K, Watanabe M, Sakimura K, Kano M.
  • Journal Title: Cell Rep. Volume: 8(4) Issue: 4 Pages: 1119-29
  • DOI: 10.1016/j.celrep.2014.07.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites (2014)
  • Author(s): Otsu Y, Marcaggi P, Feltz A, Isope, P, Kollo M, Nusser Z, Mathieu B, Kano M, Tsujita M, Sakimura K, Dieudonné S
  • Journal Title: Neuron Volume: 84 Issue: 1 Pages: 137-151
  • DOI: 10.1016/j.neuron.2014.08.035
  • Peer Reviewed
• [Journal Article] Deficits in cerebellar plasticity and motor learning in a copy number variation mouse model of autism spectrum disorder. (2014)
  • Author(s): Pichon, C., Kloth, A. D., Grasselli, G., Titley, H. K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D. H., Eissa, T., Nakatani, J., Cherskov, A., Miyazaki, T., Watanabe, M., Takumi T., Kano, M., Wang S. S-H. and Hansel, C.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 5586-5586
  • DOI: 10.1038/ncomms6586
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endocannabinoid-mediated retrograde modulation of synaptic transmission (2014)
  • Author(s): Ohno-Shosaku T, Kano M
  • Journal Title: Curr Opin Neurobiol Volume: 29 Pages: 1-8
  • NAID: 120005435504
  • Peer Reviewed
• [Journal Article] Control of synaptic function by endocannabinoid-mediated retrograde signaling (2014)
  • Author(s): Kano M
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 90 Issue: 7 Pages: 235-250
  • DOI: 10.2183/pjab.90.235
  • NAID: 130004678273
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed
• [Journal Article] Neural circuits : Japan (2014)
  • Author(s): Kawaguchi Y, Kano M
  • Journal Title: Front Neural Circuits Volume: 8 Pages: 135-135
  • DOI: 10.3389/fncir.2014.00135
  • Peer Reviewed
• [Journal Article] 脳の機能発達を担うシナプス刈り込みの機構 (2014)
  • Author(s): 上阪直史、川田慎也、狩野方伸
  • Journal Title: Brain and Nerve Volume: 9 Pages: 1069-1077
  • NAID: 40020203342
• [Journal Article] The recurrent case for the Renshaw cell. (2014)
  • Author(s): Bhumbra G, Bannatyne A, Watanabe M, Todd AJ, Maxwell D, Beato M
  • Journal Title: J Neurosci, Volume: 34 Issue: 3 Pages: 12919-12932
  • DOI: 10.1111/ejn.12470
  • Peer Reviewed
• [Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain Is crucial for cerebellar function (2014)
  • Author(s): Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
  • Journal Title: Journal of Neuroscience Volume: 34 Issue: 7 Pages: 2702-2712
  • DOI: 10.1523/jneurosci.3542-13.2014
  • Peer Reviewed
• [Journal Article] Endocannabinoid-mediated retrograde modulation of synaptic transmission (2014)
  • Author(s): Ohno-Shosaku T, Kano M
  • Journal Title: Curr Opin Neurobiol Volume: (in press) Pages: 1-8
  • DOI: 10.1016/j.conb.2014.03.017
  • Peer Reviewed
• [Journal Article] Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIa and Calcineurin. (2013)
  • Author(s): Fujii H, Inoue M, Okuno H, Sano Y; Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
  • Journal Title: Cell Reports Volume: 3(印刷中)(掲載確定) Issue: 4 Pages: 978-987
  • DOI: 10.1016/j.celrep.2013.03.033
  • Peer Reviewed
• [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits (2013)
  • Author(s): Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
  • Journal Title: Neuron Volume: 78(5) Issue: 5 Pages: 839-854
  • DOI: 10.1016/j.neuron.2013.03.031
  • Peer Reviewed
• [Journal Article] Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum (2013)
  • Author(s): Mikuni et al.
  • Journal Title: Neuron Volume: 78 Issue: 6 Pages: 1024-1035
  • DOI: 10.1016/j.neuron.2013.04.036
  • Peer Reviewed
• [Journal Article] Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. (2013)
  • Author(s): Keimpema E, Alpar A, Howell F, Malenczyk K, Hurd YL,Watanabe M, Sakimura K, Kano M, Doherty P, Harkany T
  • Journal Title: Scientific Rep. Volume: 3 Issue: 1 Pages: 2093-2093
  • DOI: 10.1038/srep02093
  • Peer Reviewed
• [Journal Article] Functional labeling of neuronal ensemble and axonal projections in vivo using a synthetic activity-dependent promoter E-SARE. (2013)
  • Author(s): Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H.
  • Journal Title: Nature Methods Volume: 10 Issue: 9 Pages: 889-895
  • DOI: 10.1038/nmeth.2559
  • Peer Reviewed
• [Journal Article] Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. (2013)
  • Author(s): Hashimotodani Y, Ohno-Shosaku T, Tanimura A, Kita Y, Sano Y, Shimizu T, Di Marzo V, Kano M.
  • Journal Title: Ｊｏｕｒｎａｌ ｏｆ Ｐｈｙｓｉｏｌｏｇｙ Volume: 591 Issue: 19 Pages: 4765-4776
  • DOI: 10.1113/jphysiol.2013.254474
  • Peer Reviewed
• [Journal Article] Disruption of cerebellar microzonal organization in GluD2 (GluRd2) knockout mouse. (2013)
  • Author(s): Hashizume M, Miyazaki T, Sakimura K, Watanabe M, Kitamura K, Kano M
  • Journal Title: Front Neural Circuits Volume: 7 Pages: 130-130
  • DOI: 10.3389/fncir.2013.00130
  • Peer Reviewed
• [Journal Article] Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development. (2013)
  • Author(s): Yoshinobu Kawamura, Hisako Nakayama, Kouichi Hashimoto, Kenji Sakimura, Kazuo Kitamura and Masanobu Kano.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 2732-2732
  • DOI: 10.1038/ncomms3732
  • Peer Reviewed
• [Journal Article] Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum. (2013)
  • Author(s): Kamikubo, Y., Shimomura, T., Fujita, Y., Tabata, T., Kashiyama, T., Sakurai, T., Fukurotani, K., Kano, M.
  • Journal Title: J. Neurosci Volume: 33 Issue: 47 Pages: 18661-18671
  • DOI: 10.1523/jneurosci.5567-12.2013
  • Peer Reviewed
• [Journal Article] Synapse elimination in the developing cerebellum. (2013)
  • Author(s): Hashimoto K, Kano M.
  • Journal Title: Cell Mol Life Sci Volume: 24 Issue: 24 Pages: 4667-4680
  • DOI: 10.1007/s00018-013-1405-2
  • Peer Reviewed
• [Presentation] Molecular, cellular and circuit mechanisms of activity-dependent synapse elimination in the developing cerebellum (2019)
  • Author(s): Kano M
  • Organizer: International Symposium : Current Perspectives on Functional and Dysfunctional Neural Circuits
• [Presentation] Discovery and investigation of cerebellar long-term depression at Masao Ito's lab (2019)
  • Author(s): Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor (2019)
  • Author(s): Nagahama K, Sakoori K, Watanabe T, Uesaka N, Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum (2019)
  • Author(s): Kushibe K, Mercier C, Watanabe T, Miyazaki T, Yamasaki M, Watanabe M, Uesaka N, Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Activity-dependent synapse elimination in the developing cerebellum (2019)
  • Author(s): Uesaka N, Kao TH, Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 10 (2019)
  • Author(s): Watanabe T, Inoue S, Akamatsu T, Suzuki H, Abe M, Sakimura K, Uesaka N, Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Modulation of dentate granule cell activity during fear memory extinction in freely moving mice (2019)
  • Author(s): Carrier-Ruiz A, Sugaya Y, Kano M
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress (第9回アジア・オセアニア生理学会連合2019年大会)
• [Presentation] Neural circuit mechanisms of synapse elimination in the developing cerebellum (2018)
  • Author(s): Kano M
  • Organizer: The 9th International Symposium of the Society for Research on the Cerebellum and Ataxias
• [Presentation] Mechanisms underlying climbing fiber synapse elimination during postnatal cerebellar development (2018)
  • Author(s): Kano M
  • Organizer: The 75th FUJIHARA Seminar : Cerebellum as a CNS Hub - from its evolution to therapeutic strategy
• [Presentation] Neural circuit mechanisms underlying activity-dependent synapse elimination in the developing cerebellum (2018)
  • Author(s): Kano M
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum (2018)
  • Author(s): Choo M, Uesaka N, Watanabe M, Sakimura K, Kano M
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Impaired synapse development in mouse medial prefrontal cortex by deletion of a histone-modifying enzyme implicated in psyciatric disorder (2018)
  • Author(s): Nagahama K, Sakoori K, Watanabe T, Uesaka N, Kano M
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development (2018)
  • Author(s): Kao T-H, Matsuyama K, Uesaka N, Kano M
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Dentate granule cell activity during fear memory extinction in freely moving mice (2018)
  • Author(s): Carrier-Ruiz A, Sugaya Y, Kano M
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics (2018)
  • Author(s): He L, Chen S, Zachary Weitemier A, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Tsutsui-Kimura I, F-Tanaka K, McHugh TJ
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society (第41回日本神経科学大会)
• [Presentation] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics (2018)
  • Author(s): Chen S, Weitemier AZ, Zeng X, HE L, Wang X, Tao Y, Huang A, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Loong D, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, Mchugh TJ
  • Organizer: Society for Neuroscience 2018 Annual Meeting
• [Presentation] Function of the adult-born neurons in memory consolidation during sleep (2018)
  • Author(s): Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Sugaya Y, Srinivasan S, Kasuya M, Yu T-S, Vogt K, Muratani M, Ohnishi T, Singh S, Teixeira CM, Nondhalee P, Naoi T, Mchugh TJ, Kernie SG, Kano M, Sakurai T, Yanagisawa M, Sakaguchi M
  • Organizer: Society for Neuroscience 2018 Annual Meeting
• [Presentation] Activity of cerebellar climbing fibers represents forelimb movements during voluntary lever-pull task in mice (2018)
  • Author(s): Hidaka N, Tsutsumi S, Ikezoe K, Isomura Y, Kano M, Kitamura K
  • Organizer: Society for Neuroscience 2018 Annual Meeting
• [Presentation] Organization of the functional inputs from the sensorimotor cortex to the cerebellum revealed by transcranial optogenetic mapping (2018)
  • Author(s): Choo M, Hira R, Matsuzaki M, Ikezoe K, Augustine GJ, Kano M, Kitamura K
  • Organizer: Society for Neuroscience 2018 Annual Meeting
• [Presentation] Mechanisms of activity-dependent synapse elimination in the developing cerebellum (2018)
  • Author(s): Kano M
  • Organizer: The 8th Brain Research Institute International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Multiple phases of activity-dependent synapse elimination in the developing cerebellum (2018)
  • Author(s): Kano M
  • Organizer: The 4th Symposium of NEUROSCIENCE NETWORK IN KOBE
  • Invited
• [Presentation] 生後発達期のマウス前頭前野のニューロンにおいて統合失調症患関連分子Setdlaをノックダウンした場合のシナプス伝達の減弱 (2018)
  • Author(s): 長濱健一郎、佐郡和人、渡邉貴樹、上阪直史、狩野方伸
  • Organizer: 第95回日本生理学会大会
  • Int'l Joint Research
• [Presentation] Dentate granule cell activity during fear memory extinction in freely moving mice (2018)
  • Author(s): Carrier-Ruiz A, Sugaya Y, Kano M
  • Organizer: 第95回日本生理学会大会
  • Int'l Joint Research
• [Presentation] Development of gene-manipulated methods for animal models, mouse, rat and marmoset, for the analysis of brain function (2018)
  • Author(s): K. SAKIMURA
  • Organizer: The 8th BRI International Symposium
  • Int'l Joint Research / Invited
• [Presentation] 運動学習および行動柔軟性に影響をおよぼす因子 : カンナビノイド系とテオブロミン (2018)
  • Author(s): 米田貢、谷上颯、臼田明莉、中川雅崇、菊池ゆひ、杉本直俊、少作隆子
  • Organizer: 第95回 日本生理学会大会
  • Int'l Joint Research
• [Presentation] Anatomical pathway for perioral sensory signals to the inferior olive in the mouse. (2018)
  • Author(s): Kubo, R., Hashimoto, K.
  • Organizer: 第95回 日本生理学会大会
  • Int'l Joint Research
• [Presentation] 神経細胞のResonance特性に関わるイオンチャネルの解析 (2017)
  • Author(s): 橋本浩一, 槇殿佳子, 中山寿子, 山崎美和子, 宮崎太輔, 小林和人, 渡辺雅彦, 狩野方伸, 崎村建司
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松(静岡県・浜松市)
  • Year and Date: 2017-03-30
• [Presentation] 2-AG合成酵素DGLα欠損マウスはCB1受容体欠損マウスと同様のレバー押し学習障害を示す (2017)
  • Author(s): 米田貢, 谷上颯, 臼田明莉, 田端祐樹, 菊池ゆひ, 少作隆子
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松(静岡県・浜松市)
  • Year and Date: 2017-03-29
• [Presentation] Theobromine crosses the blood brain barrier resulting in increased phosphorylation of vasodilator-stimulated phosphoprotein and cAMP-response element-binding protein in the mouse brain (2017)
  • Author(s): Sugimoto N, Katakura M, Matsuzaki K, Yoneda M, Sumiyoshi E, Ohno-Shosaku T, Yachie A, Shido O.
  • Organizer: 21st International Conference of FFC
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2017-03-25
  • Int'l Joint Research
• [Presentation] Mechanisms of developmental synapse elimination in the cerebellum (2017)
  • Author(s): 狩野方伸
  • Organizer: Symposium on “Brain Networks : From Molecules to Diseases”
  • Place of Presentation: Nanyang(シンガポール)
  • Year and Date: 2017-03-17
  • Int'l Joint Research / Invited
• [Presentation] Roles of RNA editing in neuropathic pain after peripheral nerve injury神経障害性疼痛におけるRNA編集異常とその役割 (2017)
  • Author(s): 内田仁司、崎村建司、伊藤誠二
  • Organizer: 第90回日本薬理学会
  • Place of Presentation: 長崎ブリックホール(長崎県・長崎市)
  • Year and Date: 2017-03-16
• [Presentation] Regulation of climbing fiber synapse elimination in the developing cerebellum by retrograde signaling (2017)
  • Author(s): Uesaka N, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Functions of cerebellar modules during goal-directed behavior (2017)
  • Author(s): Kitamura K, Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Endocannabinoid, 2-arachidonoylglycerol plays important roles during neuronal circuit formation in the mouse barrel cortex (2017)
  • Author(s): Kimura F, Itami C, Sakimura K, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Key roles of cannabinoid CBI receptor and 2-arachidonoylglycerol in the regulation of excitatory synaptic transnission in the bed nucleus of the stria terminalis and neuropathic pain (2017)
  • Author(s): Kato A, Sakoori K, Sakimura K, Sugaya Y, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] BDNF to TrkB sigaling promotes climbing fiber synapse elimination in the developing cerebellum (2017)
  • Author(s): Choo MJ, Miyazaki T, Yamasaki M, Kawamura M, Nakazawa T, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Involvement of Endc3b, a fibronectin type Ⅲ domain-containing protein, in climbing fiber synapse elimination during postnatal cerebellar development (2017)
  • Author(s): Mercier C, Watanabe T, Miyazaki T, Watanabe M, Uesaka N, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Calcium channels in cerebellar synapses bind to extracellular ligand and organize presynaptic active zones (2017)
  • Author(s): Nishimune H, Mizushige T, Uesaka N, Numata T, Chen J, Badawi Y, Mori Y, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Maturation of cerebellar climbig fiber and Purkinje cell population activities during postnatal development (2017)
  • Author(s): Mahoney M, Good JM, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Activation of mTORC1 signaling in cerebellar Purkinje cells causes cell death and hypertrophy of Purkinje cells (2017)
  • Author(s): Sakai Ym, Kassai H, Nakayama H, Nakao K, Maeda T, Hahimoto K, Kano M, Aiba A
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Phospholipase Cβ3 is required for climbig fiber synapse elimination in aldolase C-positive compartments of the developing mouse cerebellum (2017)
  • Author(s): Rai Y, Watanabe T, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Optogenetic analysis of projections from the supramammillary nuleus to the dentate gyrus of the hippocampal formation (2017)
  • Author(s): Hashimotodani Y, Yanagawa Y, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Screening of autism spectrum disorder-associated molecules that are imvolved in climbing fiber-Purkinje cell synapse elimination in the developing mouse cerebellum (2017)
  • Author(s): Watanabe T, Inoue S, Uesaka N, Kano M
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Two-photon imaging of cerebellar climbing fiber signals during a voluntary movement (2017)
  • Author(s): Hidaka N, Tsutsumi S, Ikezoe K, Isomura Y, Kano M, Kitamura K
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Serotonin Rebalances Cortical Tuning and Behavior Linked to Autism Symptoms in 15q11-13 CNV Mice (2017)
  • Author(s): Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Mizuma H, Onoue H, Tamada K, Monai H, Hirase H, Miyazaki T, Watanabe M, Okabe S, Kano M, Hahimoto K, Suzuki H, Takumi T
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Molecular, cellular, and circuit mechanisms of developmental synapse elimination in the cerebellum (2017)
  • Author(s): Kano M
  • Organizer: Gordon Research Conference on Cerebellum
  • Int'l Joint Research / Invited
• [Presentation] BDNF to TrkB signaling regulated by mGlul promotes climbing fiber synapse elimination in the developing cerebellum (2017)
  • Author(s): Kano M
  • Organizer: 9th International Meeting on Metabotropic Glutamate Receptors
  • Int'l Joint Research / Invited
• [Presentation] The metabotropic glutamate receptor subtype 1 mediates visual-experience dependent maintenance of synaptic connectivity in the dorsal lateral geniculate nucleus (2017)
  • Author(s): M. NARUSHIMA, M. UCHIGASHIMA, Y. YAGASAKI, T. HARADA, Y. NAGUMO, N. UESAKA, K. HASHIMOTO, A. AIBA, M. WATANABE, M. MIYATA, M. KANO
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 duplication mice (2017)
  • Author(s): N. NAKAI, M. NAGANO, F. SAITOW, Y. WATANABE, Y. KAWAMURA, K. TAMADA, H. MONAI, H. HIRASE, H. MIZUMA, H. ONOE, T. MIYAZAKI, M. WATANABE, S. OKABE, M. KANO, K. HASHIMOTO, H. SUZUKI, T. TAKUMI
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Rational engineering of XCaMPs, a multicolor GECI suite for In vivo imaging of brain circuit dynamics (2017)
  • Author(s): M. INOUE, A. TAKEUCHI, S. MANITA, S. -I. HORIGANE, R. KAWAKAMI, K. YAMAGUCHI, M. SAKAMOTO, H. YOKOYAMA, R. KIM, S. TAKEMOTO-KIMURA, M. ABE, K. SAKIMURA, T. NEMOTO, M. KANO, H. FUJII, K. KITAMURA, H. BITO
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] CARD HyperOvaを用いたBNラットの過剰排卵誘起処置の有用性 (2017)
  • Author(s): 中務胞、夏目里恵、崎村建司
  • Organizer: 第64回日本実験動物学会総会
• [Presentation] GluD1・Cbln1複合体は分界条床核GABA作動性神経と結合腕傍核由来の神経終末との接着に関与する (2017)
  • Author(s): 今野幸太郎、森さくら、崎村建司、柚崎通介、渡辺雅彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] GABAニューロン前駆細胞の一部はグリア細胞に分化する (2017)
  • Author(s): 江角重行、柳川右千夫、崎村建司、鹿川哲史、石龍徳、竹林浩秀、玉巻伸章
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡俊邦、佐藤朝子、知見聡美、大久保直、阿部学、川村名子、中尾聡宏、小田佳奈子、酒井清子、前田宜俊、神保幸弘、田中稔、山本美丘、佐藤俊哉、藤沢信義、崎村建司、南部篤
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] 大脳皮質Arc経路活性化による遠隔記憶セルアンサンブルの制御 (2017)
  • Author(s): 金亮、酒井一輝、川島尚之、近藤弥生、井上昌俊、野中美応、坂本雅行、岡本理子、阿部学、崎村建司、今吉格、奥野浩行、尾藤晴彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Loss of autism susceptibility gene, Auts2 induces the excessive synaptic formation in mouse forebrains. (2017)
  • Author(s): 山田 光代、堀 啓、坂本 亜沙美、阿部 学、崎村建司、曽根 雅紀、星野 幹雄
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] SRF転写活性化因子MKL2の機能解析 : 新規アイソフォームSOLOISTを中心としてFunctional analyses of SRF coactivator MKL2 including a novel isoform SOLOIST (2017)
  • Author(s): 田邉 広樹、石橋 悠太、庄司 しずく、久保 友喜美、袴田 知之、田中 拓郎、森 寿、和泉 宏謙、崎村 健司、福地 守、津田 正明、田渕 明子
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] CAST/ELKS deletion from photoreceptor causes blindness by synaptic and neural remodeling during retinal maturation (2017)
  • Author(s): 萩原 明、北原 陽介、Vogl Christian、阿部 学、橘田 涼、太田 啓介、中村 桂一郎、崎村 建司、Moser Tobias、西 昭徳、大塚 稔久
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] CRF-Venus ΔNeoマウスの分界条床核外側部CRHニューロンのシナプス入力の性差-ホルマリンテストを用いて Sex specific changes in mEPSC of CRH neurons in the lateral BST in CRF-Venus △Neo mice in association with formalin test (2017)
  • Author(s): 萩原 裕子、崎村 建司、井樋 慶一、舩橋 利也
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] プルキンエ細胞に発現するカルシニューリンB1サブユニットは抑制性シナプス形成過程において適切なプレーポストシナプスの接着に関わっている (2017)
  • Author(s): 宮﨑太輔、崎村建司、渡辺雅彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] ドレブリンはmGluR5およびNMDA受容体依存性LTD誘導に関わる (2017)
  • Author(s): 児島伸彦、安田浩樹、崎村建司、白尾智明
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Generation and analysis of cerebellar granule cell-specific neurexins triple knockout mice (2017)
  • Author(s): 植村 健、鈴木 絵美、小池 梨絵、川瀨 詩織、栗原 大河、崎村 建司、三品 昌美、田渕 克彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] A role of actin remodeling in cortical interneuron for critical period plasticity (2017)
  • Author(s): 候 旭濱、國見 順子、崎村 建司、杉山 清佳
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Disruption of AMPA receptor-palmitoylation leads excitatory/inhibitory imbalance and elevated seizure susceptibility (2017)
  • Author(s): 伊藤 政之、山下 真梨子、山田 大輔、奥野 浩行、阿部 学、山崎 真弥、夏目 里恵、金子 雅規、貝塚 利恵、崎村 建司、関口 正幸、和田 圭司、星野 幹雄、三品 昌美、林 崇
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Behavioral analyses of forebrain specific knock-out mice of an orphan metabotropic receptor Prrt3 and screening of small molecule library toward identification of its ligand (2017)
  • Author(s): 陳 以珊、山本 友美、周 麗、夏目 里恵、今野 幸太郎、上杉 志成、渡辺 雅彦、高雄 啓三、宮川 剛、崎村建司、久保 義弘
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Depression-like behavior in the GluD1 deficient mice was remedied by antidepressants (2017)
  • Author(s): 中本千尋、夏目 里恵、阿部 学、川村 名子、内田 仁司、渡辺 雅彦、崎村建司
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Biochemical analysis of phosphorylated CAST/ELKS in mice brain (2017)
  • Author(s): 浜田 駿、阿部 学、崎村 建司、大塚 稔久
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Gene expression and behavior analysis of microglial voltage-gated proton channels in mouse (2017)
  • Author(s): 河合 喬文、高雄 啓三、崎村建司、宮川 剛、岡村 康司
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Classification of corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus according to their differential neural projections (2017)
  • Author(s): 堀尾 修平、山形 聡、小林 憲太、加藤 成樹、崎村 建司、上山 敬司、小林 和人、井樋 慶一
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Generation of corticotropin-releasing factor neuron-selective vasopressin knockout mouse : unravelling the physiological role of vasopressin expressed in the parvocellular neurons in the hypothalamus (2017)
  • Author(s): 山形 聡、Talukder Hossain Ashraf、渡辺 真秀、周 麗、夏目 里恵、阿部 学、蔭山 和則、大門 眞、崎村 建司、井樋 慶一
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Orexin modulates Behavioral Fear Expression through Noradrenergic Neurons in the Locus Coeruleus (2017)
  • Author(s): 高橋 徹、征矢 晋吾、Thomas J Mchugh、前島 隆、阿部 学、崎村 建司、櫻井 武
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Identification and characterization of brain-enriched guanylate kinase-associated protein as a neuropathic pain-related protein in the spinal dorsal horn (2017)
  • Author(s): 片野 泰代、福田 正史、山崎 真弥、、阿部 学、渡辺 雅彦、矢尾 育子、奥村 宣明、中澤 敬信、山本 雅、崎村 建司、高尾 敏文、伊藤 誠二
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7 (2017)
  • Author(s): 小池 正人、柴田 昌宏、砂堀 毅彦、山口 隼司、崎村 建司、小松 雅明、田中 啓二、内山 安男
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] The role of Auts2 in the dentate gyrus development (2017)
  • Author(s): 江草 早紀、堀 啓、坂本 亜沙美、阿部 学、崎村 建司、郷 康広、星野 幹雄
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Visualizing single-neuron identity specified by Pcdh-b cluster (2017)
  • Author(s): 金子 涼輔、阿部 学、高鶴 裕介、渡辺 雅彦、崎村 建司、柳川 右千夫、八木 健
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] NKによるGAP-43のリン酸化は軸索成長を制御する Phosphorylation of GAP-43 by JNK regulates axonal growth (2017)
  • Author(s): 河嵜 麻実、岡田 正康、小林 大紀、野住 素広、崎村 建司、仁科 博史、武内 恒成、五十嵐 道弘
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness behavior after ablation of central serotonergic neuron (2017)
  • Author(s): 岩崎 加奈子、柿崎 美代、阿部 学、崎村 建司、船戸 弘正、柳沢 正史
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] RNA編集酵素ADAR2は神経障害性疼痛に関与する RNA editing enzyme ADAR2 contributes to neuropathic pain (2017)
  • Author(s): 内田 仁司、崎村 建司、伊藤 誠二
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Depression-like behavior in the GluD1 deficient mice was remedied by antidepressants. (2017)
  • Author(s): Chihiro Nakamoto、Rie Natsume, Manabu Abe, Meiko Kawamura, Hitoshi Uchida, Masahiko Watanabe, Kenji Sakimura
  • Organizer: 26th Meeting of the International Society for Neurochemistry
  • Int'l Joint Research
• [Presentation] Roles of Arc/arg3.1 on surface expression dynamics of AMPA receptors during structural plasticity and on cognitive refinement processes (2017)
  • Author(s): H. OKUNO、Y. ISHII, T. ENDO, M. UEHARA, Y. SUZUKI, K. MINATOHARA, A. ARAKI, M. ABE, I. IMAYOSHI, M. KAKEYAMA, K. SAKIMURA, H. BITO
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Aifl-iCre knock-in mouse line : A tool for conditional gene manipulation in microglia (2017)
  • Author(s): M. ABE、F. PENG, K. SAKIMURA ;
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging In vivo (2017)
  • Author(s): M. SAKAMOTO、M. INOUE、K. SAKAI、S. KOBARI、S. TAKEMOTO-KIMURA, M. ABE, K. SAKIMURA, H. BITO
  • Organizer: Society for Neuroscience 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] ラット卵巣卵胞内卵子の成熟培養なしでの体外受精 (2017)
  • Author(s): 中務 胞、夏目里恵、崎村建司
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] 発生および慢性疼痛下の一次知覚神経におけるRNA編集の変動 (2017)
  • Author(s): 内田 仁司、松村伸治、崎村建司、伊藤 誠二
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] ニューロンIDの可視化 ～クラスター型プロトカドヘリンの発現解析～ (2017)
  • Author(s): 金子 涼輔、阿部学、高鶴裕介、渡辺雅彦、崎村建司、柳川 右千夫、八木 健
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] PKN1はリンパ球の細胞運動・トラフィッキングを制御する (2017)
  • Author(s): 窪内 康二、團野紗莉、野町昭、平田多佳子、松尾一彦、中山隆志、佐藤亮介、杉浦麗子、阿部学、崎村建司、若菜茂晴、大崎博之、鴨志田伸吾、向井 秀幸
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] 運動学習における内因性カンナビノイド2-AGとCB1受容体の関与 (2017)
  • Author(s): 米田貢、谷上颯、中川雅崇、臼田明莉、田端佑樹、少作隆子
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] 3レバーオペラント課題における2-AG合成酵素DGLα欠損マウスの適応行動の障害 (2017)
  • Author(s): 米田貢, 谷上颯, 田端佑樹, 越後亮介, 少作隆子
  • Organizer: 日本生物学的精神医学会・日本神経精神薬理学会 合同年会
• [Presentation] マウスヒゲ領域から下オリーブ核に至る感覚経路の解析. (2017)
  • Author(s): 久保怜香、橋本浩一
  • Organizer: 生理学研究所研究会「シナプス・神経回路機能の時空間制御」
• [Presentation] Microglia Dependent Development of Neuronal Circuits in the Cerebellum. (2017)
  • Author(s): Nakayama, H., Abe, M., Morimoto, M., Sakimura, K., Hashimoto, K.
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Activation of mTORC1 signaling in cerebellar Purkinje cells causes cell death and hypertrophy of Purkinje cells. (2017)
  • Author(s): Sakai, Y., Kassai, H., Nakayama, H., Nakao, K., Maeda, T., Hashimoto, K., Kano, M., Aiba, A.
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Genetic manipulation of mTORC1 signaling in mouse cerebellar Purkinje cell (2016)
  • Author(s): H. KASSAI1, Y. SAKAI1, H. NAKAYAMA4, T. MAEDA2, K. HASHIMOTO4, M. KANO3, A. AIBA
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Automated 3D analysis of confocal microscopy images by 3D-ACE reveals widespread molecular and cellular adaptions in the spinal nociceptive circuitry of monoacylglycerol lipase knockout mice (2016)
  • Author(s): C. I. Pongor, S. G. Woodhams, B. Benjamin, B. Dudok, L. Barna, M. Kano, K. Sakimura, M. Watanabe, I. Katona
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Functional differeces in climbing fiber inputs to distinct cerebellar stripes during goal-directed behavior (2016)
  • Author(s): S. Tsutsumi, N. Hidaka, Y. Isomura, M. Matsuzaki, K. Sakimura, M. Kano, K. Kitamura
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Physiological and morphological roles of endocannabinoid 2-arachidonoylglycerol in the developing neuronal circuit in the mouse barrel cortex (2016)
  • Author(s): Chiaki Itami, K. Sakimura, M. Kano, F. Kimura
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] SCOP-dependent circadian regulation of memory formation for novel object (2016)
  • Author(s): K. Shimizu, Y. Kobayashi, E. Nakatsuji, M. Yama zaki, K. Sakimura, Y. Fukada
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDiego(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Distribution of cortictropin-releasing factor neurons in the mouse brain : a study using cortisotropin-releasing factor modified yellow fluorescent protein knock-in mouse (2016)
  • Author(s): K. Itoi, J. Kono, K. Konno, A. H. Talukder, T. Fuse, K. Uchida, S. Yamagata, S. Horio, M. Abe, M. Watanabe, K. Sakimura
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (Neuroscience2016)
  • Place of Presentation: SanDeigo(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 細胞膜resonance特性に関わるイオンチャネル (2016)
  • Author(s): 橋本浩一、槇殿佳子、中山寿子
  • Organizer: 第68回 日本生理学会 中国四国地方会
  • Place of Presentation: 岡山大学(岡山県・岡山市)
  • Year and Date: 2016-11-06
• [Presentation] Neuronal activity and retrograde signaling that regulate synapse elimination in the developing cerebellum (2016)
  • Author(s): 狩野方伸
  • Organizer: The 47th NIPS International Symposium “Decoding Synapses”
  • Place of Presentation: 生理学研究所(兵庫県・岡崎市)
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] デルタ型グルタミン酸受容体サブユニット機能とその量的関連 (2016)
  • Author(s): 中本千尋、川村名子、夏目里恵、阿部学、渡辺雅彦、崎村建司
  • Organizer: 第59回日本神経化学会
  • Place of Presentation: 福岡国際会議場(福岡県・福岡市)
  • Year and Date: 2016-09-08
• [Presentation] Ion channels responsible for the resonant property of neurons in the inferior olive. (2016)
  • Author(s): 橋本浩一、中山寿子、松本佳子
  • Organizer: 第59回日本神経化学会
  • Place of Presentation: 福岡国際会議場(福岡県・福岡市)
  • Year and Date: 2016-09-08
• [Presentation] マウス受精卵電気穿孔法を用いたCRISPR/Cas9システムによる内在性タンパク質へのタグ付加の試み (2016)
  • Author(s): 阿部学、夏目里恵、中務胞、崎村建司
  • Organizer: 第1回 ゲノム編集学会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2016-09-06
• [Presentation] Theobromine crosses the blood brain barrier in vivo resulting in increased phosphorylation of vasodilatorstimulated phosphoprotein in the mouse brain (2016)
  • Author(s): Sugimoto N, Katakura M, Matsuzaki K, Ohno-Shosaku T, Yachie A, Shido O.
  • Organizer: Physiology 2016
  • Place of Presentation: Dublin(イギリス)
  • Year and Date: 2016-07-30
  • Int'l Joint Research
• [Presentation] Cerebellar lobules receive spatiotemporally specific inputs from the cerebral cortex (2016)
  • Author(s): Myeong Jeong Choo, Riichiro Hira, Masanori Matsuzaki, Masanobu Kano, Kazuo Kitamura
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-22
• [Presentation] GLuD1 and Cbln1 interation plays an important role in synapse formation between particular neurochemical nucleus and dorsolateral geniculate nucleus (2016)
  • Author(s): Kohtaro Konno, Koji Nishikawa, Shinji Yamada, Michisuke Yuzaki, Kenji Sakimura, Masahiko Watanabe
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-22
• [Presentation] Roles of the endocannabinoid 2-arachidonoylglycerol in neuronal circuit development of the mouse barrel cortex (2016)
  • Author(s): Chiaki Itami, Kenji Sakimura, Masanobu Kano, Fumitaka Kimura
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-22
• [Presentation] Visualizing single-neuron identity specified by Pcdh-b cluster (2016)
  • Author(s): Ryosuke Kaneko, Manabu Abe, Yusuke Takatsuru, Masahiko Watanabe, Kenji Sakimura, Yuchio Yanagawa, Takeshi Yagi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-21
• [Presentation] Possible role of endocannabinoid signaling in autism-like behevior in mice (2016)
  • Author(s): Kazuto Sakoori, Maya Yamazaki, Kenji Sakimura, Masanobu Kano
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-21
• [Presentation] Maintenance of excitatory-inhibitory balance in brain by AMPA receptor palmitoylation (2016)
  • Author(s): Mariko Yamashita, Hiroyuki Okuno, Manabu Abe, Maya Yamazaki, Rie Natsume, Kenji Sakimura, Mikio Hoshino, Masayoshi Mishina, Takashi Hayashi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-21
• [Presentation] Layer specific contribution of diacylglycerol lipase-a to ocular dominance plasticity in the mouse visual cortexLayer specific contribution of diacylglycerol lipase-a to ocular dominance plasticity in the mouse visual cortex (2016)
  • Author(s): Katsuro Kameyama, Taisuke Yoneda, Takahiro Gotou, Keiko Terata, Kenji Sakimura, Masanobu Kano, Yoshio Hata
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Cortical intermediate GABAergic neuron progenitors divide symmertricalli to produce similar GABAergic neuron pairs (2016)
  • Author(s): Shigeyuki Esumi, Yuchio Yanagawa, Kenji Sakimura, Nobuyuki Tamamaki
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Development of GluN2B NMDA receptor subtype in spinal motoneurons : A study using Grin2b-flox mice (2016)
  • Author(s): Takae Ohno, Satoshi Fukuda, Naoyuki Murabe, Noriko Isoo, Hiroaki Mizukami, Keiya Ozawa, Kenji Sakimura, Masaki Sakurai
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Mapping of coticortropin-releasing factoe neurons in mouse brain : a study using a modified yellow flourescent protein knock-in mouse (2016)
  • Author(s): Keiichi Itoi, Junko Kono, Kotaro Konno, Talukder H. Ashraf, Katsuya Uchida, Toshimitsu Fuse, Manabu Abe, Rie Natsume, Shuhei Horio, Kenji Sakimura, Masahiko Watanabe
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Arc knockout mice exhibit specific impaiement during reversal learning phase in a spatial memory task (2016)
  • Author(s): Masahiro Uehara, Yusuke Suzuki, Toshihiro Endo, Masaki Kakeyama, Manabu Abe, Kenji Sakimura, Itaru Imayoshi, Haruhiko Bito, Hiroyuki Okuno
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] 3レバーオペラント課題を用いたマウスの運動学習および適応行動に対するテオブロミン摂取の効果 (2016)
  • Author(s): 米田貢, 谷上颯, 田端祐樹, 越後亮介, 杉本直俊, 少作隆子
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Transmembrane protein Dpy19L1 is required for development of the septal nucleus (2016)
  • Author(s): Keisuke Watanabe, Li Zhou, Norihisa Bizen, Rie Natsume, Manabu Abe, Kenji Sakimura, Noboru Sato, Hirohide Takebayashi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] GluN3A colocalizes with KV4.3 at non-synaptic climbing fiber-interneuron junctions in the cerebellum (2016)
  • Author(s): Xiaohong Song, Masahiro Fukaya, Miwako Yamasaki, Motokazu Uchigashima, Kohtaro Konno, Taisuke Miyazaki, Keiko Matsuda, Chihiro Nakamoto, Isabel Perez-Otano, Michisuke Yuzaki, Kenji Sakimura, Masahiko Watanabe
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] A mutation in CACNA1G causes autosomal dominant spinocerebellar ataxia. (2016)
  • Author(s): Morino H, Matsuda Y, Muguruma K, Miyamoto R, Ohsawa R, Ohtake T, Otobe R, Watanabe M, Maruyama H, Hashimoto K, Kawakami H.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-07-20
• [Presentation] Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination (2016)
  • Author(s): Ichikawa Ryoichi, Hashimoto Kouichi, Miyazaki Taisuke, Uchigashima Motokazu, Sakimura Kenji, Yamasaki Miwako, Aiba Atsu, Kano Masanobu, Masahiko Watanabe
  • Organizer: 10th FENS forum of Neuroscience
  • Place of Presentation: コペンハーゲン(デンマーク)
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Theobromine, the primary methylxanthine found in Theobroma cacao, can pass through the blood-brain barrier in mice (2016)
  • Author(s): Sugimoto N, Katakura M, Matsuzaki K, Ohno-Shosaku T, Yachie A, Shido O.
  • Organizer: Experimental Biology 2016
  • Place of Presentation: San Diego(アメリカ)
  • Year and Date: 2016-04-06
  • Int'l Joint Research
• [Presentation] 小脳皮質縞状構造への運動・認知行動に関連した登上線維入力の学習による分化 (2016)
  • Author(s): 堤新一郎、日高直樹、磯村宜和、松崎政紀、崎村建司、狩野方伸、喜多村和郎
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-24
  • Description: 【発表確定】
• [Presentation] 内因性カンナビノイド2-AGは自閉症様行動に関与する (2016)
  • Author(s): 佐郡和人、山崎真弥、崎村健司、狩野方伸
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-24
  • Description: 【発表確定】
• [Presentation] 苔状線維が放出するClqタンパク質による苔状線維-CA3シナプス機能の制御 (2016)
  • Author(s): 松田恵子、Timotheus Budisantosol、狩野方伸、渡辺雅彦、﨑村健司、A. Radu Aricescu、柚﨑通介
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-23
  • Description: 【発表確定】
• [Presentation] 1型代謝型グルタミン酸受容体による網膜-外側膝状体シナプスの成熟型結合パタンの維持 (2016)
  • Author(s): 鳴島円、内ヶ島基政、矢ヶ崎有希、原田武志、南雲康之、上阪直史、渡邉 貴樹、橋本浩一、饗場篤、渡辺雅彦、宮田麻理子、狩野方伸
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-22
  • Description: 【発表確定】
• [Presentation] 前頭側頭型認知症関連遺伝子granulinが発達期小脳のシナプス再編成を制御する (2016)
  • Author(s): 上阪直史、狩野方伸
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-22
  • Description: 【発表確定】
• [Presentation] 大脳-小脳ループの光マッピングによる解析 (2016)
  • Author(s): 秋明貞、平理一郎、松崎政紀、狩野方伸、喜多村和郎
  • Organizer: 第93日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2016-03-22
  • Description: 【発表確定】
• [Presentation] Neuroligin-2 regulates postnatal development of climbing fiber-Purkinje cell synapses in the cerebellum (2015)
  • Author(s): Lai E, Uesaka N, Kano M
  • Organizer: Neuroscience 2015
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2015-10-21
  • Description: 【発表確定】
  • Int'l Joint Research
• [Presentation] Rational design of ultrafast, high-affinity red calcium indicator for monitoring neuronal activity (2015)
  • Author(s): Inoue M, Takeuchi A, Horigane S-I, Fujii H, Kamijo S, Takemoto-Kimura S, Ohkura M, Ggengyo-Ando K, Kano M, Nakai J, Kitamura K, Bito H
  • Organizer: Neuroscience 2015
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2015-10-18
  • Description: 【発表確定】
  • Int'l Joint Research
• [Presentation] Rational design of a novel high-affinity, ultrafast, red calcium indicator R-CaMP2 (2015)
  • Author(s): Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, Bito H
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-30
  • Description: 【発表確定】
• [Presentation] Retrograde signaling involved in climbing fiber synapse elimination in the developing cerebellum (2015)
  • Author(s): Kano M, Uesaka N
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-29
  • Description: 【発表確定】
• [Presentation] The endocannabinoid 2-arachidonoyl glycerol suppresses excitatory synaptic inputs around the inner and middle molecular layers of the dentate gyrus during seizures (2015)
  • Author(s): Sugaya Y, Yamazaki M, Sakimura K, Kano M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-29
  • Description: 【発表確定】
• [Presentation] Cortical excitatory/inhibitory imbalance in a mouse model for human 15q11-13 duplication (2015)
  • Author(s): Nakai N, Watanabe Y, Kawamura Y, Miyazaki T, Watanabe M, Okabe S, Kano M, Hashimoto K, Takumi T
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-29
  • Description: 【発表確定】
• [Presentation] Knockdown of CNTNAP2 in neurons of the prefrontal cortex impairs synaptic function and causes impaired social behavior (2015)
  • Author(s): Sacai H, Sakoori K, Uesaka N, Kano M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-28
  • Description: 【発表確定】
• [Presentation] Identification of complex spikes in two-photon recording of Purkinje cell calcium responses by machine learning and ROC analysis of the performance (2015)
  • Author(s): Hoang H T, Tsutsumi S, Hashizume M, Yamashita O, Tokuda I, Sato MA, Kawato M, Kano M, Kitamura K, Toyama K
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-28
  • Description: 【発表確定】
• [Presentation] Progranulin regulates climbing fiber synapse elimination during postnatal cerebellar development (2015)
  • Author(s): Uesaka N, Abe M, Yamazaki M, Konnno K, Mikuni T, Watanabe M, Sakimura K, Kano M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-28
  • Description: 【発表確定】
• [Presentation] Roles of neuroligin-2 in inhibitory synaptic transmission and climbing fiber synapse elimination in Purkinje cells during postnatal cerebellar development (2015)
  • Author(s): Lai S K, Uesaka N, Kano M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-28
  • Description: 【発表確定】
• [Presentation] Multiple roles for neural activity in climbing fiber synapse elimination during postnatal cerebellar development (2015)
  • Author(s): Kano M
  • Organizer: Cold Spring Harbor Asia (CSHA) Conference on International Brain Projects
  • Place of Presentation: Suzhou(China)
  • Year and Date: 2015-06-21
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain (2015)
  • Author(s): Kano M
  • Organizer: Invited Lecture at Zhejiang University, College of Pharmaceutical Sciences
  • Place of Presentation: Zhejiang(China)
  • Year and Date: 2015-06-17
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Crucial Roles of 2-Arachidonoylglycerol Signaling in the Suppression of Epileptic Seizures (2015)
  • Author(s): Kano M
  • Organizer: Gordon Research Conferences Cannabinoid Function in the CNS
  • Place of Presentation: Tuscany (Italy)
  • Year and Date: 2015-05-26
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Neuronal activity and retrograde signaling that regulate synapse elimination in the developing cerebellum (2015)
  • Author(s): Kano M
  • Organizer: Invited Lecture at Institute of Neuroscience, Technische Universität München
  • Place of Presentation: München(Germany)
  • Year and Date: 2015-05-22
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] 自閉症感受性遺伝子を前頭前野でノックダウンしたマウスのシナプス機能異常と社会的行動の異常 (2015)
  • Author(s): 酒井浩旭、佐郡和人、上阪直史、狩野方伸
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-03-23
  • Description: 【発表確定】
• [Presentation] 1型代謝型グルタミン酸受容体による網膜-外側膝状体シナプスの成熟型結合パタン維持 (2015)
  • Author(s): 鳴島円、内ケ島基政、原田武志、橋本浩一、饗場篤、渡辺雅彦、宮田麻理子、狩野方伸
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-03-21
  • Description: 【発表確定】
• [Presentation] 発達期シナプス刈り込みを制御する逆行性シグナル分子の同定 (2015)
  • Author(s): 上阪直史、狩野方伸
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-03-21
  • Description: 【発表確定】
• [Presentation] 高感度、超高速赤色カルシウムインディケーターの合理的設計による開発 (2015)
  • Author(s): 井上昌俊、竹内敦也、堀金慎一郎、大倉正道、玄行-安藤恵子、藤井哉、上條諭志、竹本-木村さやか、狩野方伸、中井淳一、喜多村和郎、尾藤晴彦
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-03-21
  • Description: 【発表確定】
• [Presentation] 体性感覚野における経験依存的な感覚シナプス入力のクラスター化 (2015)
  • Author(s): 喜多村和郎、狩野方伸
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-03-21
  • Description: 【発表確定】
• [Presentation] Activity-dependent synapse elimination in developing cerebellum (2015)
  • Author(s): Kano M.
  • Organizer: OIST Symposium “Recent findings on the cerebellar microcircuitry”
  • Place of Presentation: 沖縄科学技術大学院大学Seminar Room C210(沖縄県恩納村)
  • Year and Date: 2015-01-29
  • Description: 【発表確定】
  • Invited
• [Presentation] Deficiency of glutamate transporter in astrocyte increases brain excitability and induces Tourette's Syndrome-like excessive repetitive behaviours in mice (2014)
  • Author(s): T. AIDA, J. YOSHIDA, M. NOMURA, A. TANIMURA, Y. IINO, M. SOMA, N. BAI, Y. ITO, W. CUI, H. AIZAWA, T. NAGAI, N. TAKATA, R. TAKAYANAGI, M. KANO, M. GÖTZ, H. HIRASE, K. TANAKA
  • Organizer: Society for Neuroscience
  • Place of Presentation: the Walter E. Washington Convention Center(アメリカ、ワシントンDC)
  • Year and Date: 2014-11-18
  • Description: 【発表確定】
• [Presentation] The endocannabinoid 2-arachidonoyl glycerol suppresses seizures by decreasing excitatory synaptic input around the inner molecular layer of the dentate gyrus (2014)
  • Author(s): Y. SUGAYA, M. YAMAZAKI, K. SAKIMURA, M. KANO
  • Organizer: Society for Neuroscience
  • Place of Presentation: the Walter E. Washington Convention Center(アメリカ、ワシントンDC)
  • Year and Date: 2014-11-18
  • Description: 【発表確定】
• [Presentation] Deficits in cerebellar plasticity and motor learning in a copy number variation mouse model of autism spectrum disorder (2014)
  • Author(s): C. PIOCHON, D.H. SIMMONS, A.D. KLOTH, G. GRASSELLI, H.K. TITLEY, H. NAKAYAMA, K. HASHIMOTO, V. WAN, T. EISSA, J. NAKATANI, A. CHERSKOV, T. MIYAZAKI, M. WATANABE, T. TAKUMI, M. KANO, S.S.H. WANG, C. HANSEL
  • Organizer: Society for Neuroscience
  • Place of Presentation: the Walter E. Washington Convention Center(アメリカ、ワシントンDC)
  • Year and Date: 2014-11-16
  • Description: 【発表確定】
• [Presentation] Requirement of mGluRl for experience-dependent remodeling of mouse retinogeniculate synapses (2014)
  • Author(s): Kano M.
  • Organizer: 8th International Meeting on Metaborropic Glutamate Receptors
  • Place of Presentation: Grande Alvergo Capotaormina Hotel (イタリア、タオルミナ)
  • Year and Date: 2014-09-30
  • Description: 【発表確定】
  • Invited
• [Presentation] グルタミン酸トランスポーターの欠損は過剰な繰り返し行動を引き起こすGlial glutamate transporter deficiency alteres neurotransmission, leading to excessive repetitive behaviours in mice (2014)
  • Author(s): 相田知海、吉田純一、野村政壽、谷村あさみ、飯野祐介、相馬美歩、Bai Ning、伊藤亨子、Cui Wangpeng、相澤秀紀、永井てるみ、高田則雄、髙栁涼一、狩野方伸、Magdalena Götz、平瀬肇、田中光一
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-13
  • Description: 【発表確定】
• [Presentation] 2-アラキドノイルグリセロールと関連物質によるシナプス伝達調節Modulation of synaptic transmission by 2-arachidonoylglycerol and its metabolites (2014)
  • Author(s): 少作隆子、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-12
  • Description: 【発表確定】
• [Presentation] 内因性カンナビノイド、2アラキドノイルグリセロールはCB1、CB2受容体を介して発作を抑制するThe endocannabinoid 2-arachidonoyl glycerol suppresses epileptic seizures through the activation of CBl and CB2 receptors (2014)
  • Author(s): 菅谷佑樹、山崎真弥、崎村建司、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-12
  • Description: 【発表確定】
• [Presentation] 強化学習に基づいた、サル線条体に存在する内因性エンドカンナビノイドの意志決定に関する役割The role of endocannabinoid signaling in the striatum for reinforcement learning (2014)
  • Author(s): 上田康雅、岡崎哲、山中航、鮫島和行、榎本一紀、狩野方伸、木村實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-12
  • Description: 【発表確定】
• [Presentation] 感覚経験依存的神経回路の維持機構とその分子メカニズムMolecular mechanism of sensory experience-dependent maintenance of neuronal circuits (2014)
  • Author(s): 宮田麻理子、鳴島円、内ヶ島基政、橋本浩一、原田武志、餐場篤、渡辺雅彦、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-12
  • Description: 【発表確定】
• [Presentation] 発達期小脳シナプス刈り込みにプルキンエ細胞由来BDNFが寄与しているRetrograde BDNF signaling from Purkinje cell regulates synapse elimination in the developing cerebellum (2014)
  • Author(s): 秋明貞、宮崎太輔、山崎真弥、谷村あさみ、上阪直史、渡辺雅彦、崎村健司、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-12
  • Description: 【発表確定】
• [Presentation] CaMKIIαとCalcineurinによる神経入力情報の非線形デコーディングNonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKII α and Calcineurin (2014)
  • Author(s): 藤井哉、井上昌俊、奥野浩行、佐野慶和、竹本-木村さやか、喜多村和郎、狩野方伸、尾藤晴彦
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11
  • Description: 【発表確定】
• [Presentation] 新規の高感度緑色カルシウム指示薬Cal-520を用いたin vitroおよびin vivoにおける神経活動のイメージングHighly sensitive calcium imaging of neural activity in vitro and in vivo with a new fluorescent calcium indicator, Cal-520 (2014)
  • Author(s): 竹内敦也、多田真弓、橋爪幹、喜多村和郎、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11
  • Description: 【発表確定】
• [Presentation] 網膜―外側膝状体シナプスにおける1型代謝型グルタミン酸受容体依存的なシナプス維持機構Type 1 metabotropic glutamate receptor is involved in experience-dependent maintenance of retinogeniculate synapses in the mouse visual system (2014)
  • Author(s): 鳴島円、内ヶ島基政、橋本浩一、原田武志、饗場篤、渡辺雅彦、宮田麻理子、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11
  • Description: 【発表確定】
• [Presentation] マウス一次視覚野におけるDiacylglycerol lipase-αの発達期可塑性への寄与Contribution of diacylglycerol lipase-α to developmental plasticity in mouse V1 (2014)
  • Author(s): 亀山克朗、米田泰輔、後藤隆浩、寺田慧子、中西真実、崎村建司、狩野方伸、畠義郎
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11
  • Description: 【発表確定】
• [Presentation] Sema3AとSema7Aによる逆行性シグナルがシナプス刈り込みを制御しているRetrograde signaling by Sema3A and Sema7A regulates synapse elimination in the developing cerebellum (2014)
  • Author(s): 上阪直史、内ヶ島基政、三國貴康、中澤敬信、中尾晴美、平井宏和、饗場篤、渡辺雅彦、狩野方伸
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11
  • Description: 【発表確定】
• [Presentation] IMPAIRMENT OF DEVELOPMENTAL SYNAPSE ELIMINATION IN THE CEREBELLUM OF PURKINJE CELL-SPECIFIC BDNF KNOCKOUT MICE (2014)
  • Author(s): M. Choo, T. Miyazaki, M. Yamasaki, A. Tanimura, N. Uesaka, M. Watanabe, K. Sakimura, M. Kano
  • Organizer: 9th Federation of European Neuroscience Sosieties Forum of Neuroscience
  • Place of Presentation: MiCo Congress Centre(イタリア、ミラノ)
  • Year and Date: 2014-07-07
  • Description: 【発表確定】
• [Presentation] SCREENING OF RETROGRADE SIGNALING MOLECULES FOR SYNAPSE ELIMINATION IN THE DEVELOPING CEREBELLUM (2014)
  • Author(s): N. Uesaka, M. Uchigashima, T. Mikuni, T. Nakazawa, H. Hirai, M. Watanabe, M. Kano
  • Organizer: 9th Federation of European Neuroscience Sosieties Forum of Neuroscience
  • Place of Presentation: MiCo Congress Centre(イタリア、ミラノ)
  • Year and Date: 2014-07-07
  • Description: 【発表確定】
• [Presentation] A THEORY TO EXPLAIN SYNAPTIC CLUSTERING IN DENDRITES (2014)
  • Author(s): R. Cazé, C. Clopath, K. Kitamura, M. Kano, S.R.
  • Organizer: 9th Federation of European Neuroscience Sosieties Forum of Neuroscience
  • Place of Presentation: MiCo Congress Centre(イタリア、ミラノ)
  • Year and Date: 2014-07-07
  • Description: 【発表確定】
• [Presentation] MICROZONAL ORGANIZATION DURING SENSORIMOTOR ACTIVITIES IN RELATION TO ALDOLASE C/ZEBRIN II COMPARTMENT IN THE CEREBELLUM (2014)
  • Author(s): S. Tsutsumi, M. Yamazaki, T. Miyazaki, M. Watanabe, K. Sakimura, Y. Isomura, M. Matsuzaki, M. Kano, K. Kitamura
  • Organizer: 9th Federation of European Neuroscience Sosieties Forum of Neuroscience
  • Place of Presentation: MiCo Congress Centre(イタリア、ミラノ)
  • Year and Date: 2014-07-07
  • Description: 【発表確定】
• [Presentation] MOLECULAR PATHWAY TO LONG TERM POTENTIATION AT PARALLEL FIBER TO PURKINJE SYNAPSES (2014)
  • Author(s): F. Binda, M. Kano, K. Sakimura, P. Isope
  • Organizer: 9th Federation of European Neuroscience Sosieties Forum of Neuroscience
  • Place of Presentation: MiCo Congress Centre(イタリア、ミラノ)
  • Year and Date: 2014-07-06
  • Description: 【発表確定】
• [Presentation] Cerebellar Contribution to Brain Function From Molecules to Behavior (2014)
  • Author(s): Kano M.
  • Organizer: 6th International Congress of the Society for Research on the Cerebellum
  • Place of Presentation: Centro Congressi Fondazione Santa Lucia IRCCS (イタリア、ローマ)
  • Year and Date: 2014-07-03
  • Description: 【発表確定】
  • Invited
• [Presentation] Retrograde signaling for climbing fiber synapse elimination (2014)
  • Author(s): Kano M.
  • Organizer: Collaborations in Neuroscience Symposium
  • Place of Presentation: The MAX PLANCK Florida Institute for Neuroscience(アメリカ、フロリダ州ジュピター)
  • Year and Date: 2014-05-10
  • Description: 【発表確定】
  • Invited
• [Presentation] 内因性カンナビノイドは歯状回内分子層の興奮性シナプス入力を抑制し発作を軽減する (2014)
  • Author(s): 菅谷佑樹, 山崎真弥, 﨑村建司, 狩野方伸
  • Organizer: 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
  • Year and Date: 2014-03-18
• [Presentation] 逆行性シグナルをになう内因性カンナビノイド、2-アラキドノイルグリセロールはジアシルグリセロールリパーゼαによってオンデマンドに産生される (2014)
  • Author(s): 橋本谷祐輝, 少作隆子, 狩野方伸
  • Organizer: 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
  • Year and Date: 2014-03-18
• [Presentation] 発達期小脳シナプス刈り込みにプルキンエ細胞由来BDNFが寄与している (2014)
  • Author(s): 秋明貞, 宮崎太輔, 山崎真弥, 谷村あさみ, 上阪直史, 渡辺雅彦, 﨑村建司, 狩野方伸
  • Organizer: 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
  • Year and Date: 2014-03-18
• [Presentation] シナプス刈り込みにおける逆行性シグナルの役割 (2014)
  • Author(s): 上阪直史, 内ヶ島基政, 三國貴康, 平井宏和, 渡辺雅彦, 狩野方伸
  • Organizer: 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
  • Year and Date: 2014-03-16
• [Presentation] An autism-associated neuroligin-3 mutation impairs developmental synapse elimination in the cerebellum (2013)
  • Author(s): Lai E, Nakayama H, Nakazawa T, Tabuchi K, Hashimoto K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-13
• [Presentation] Fine scale correspondence between the cerebellar microzones and the aldolase C compartments in mice (2013)
  • Author(s): Tsutsumi S, Yamazaki M, Sakimura K, Kitamura K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-12
• [Presentation] Impairment of cerebellar microzonal organization by aberrant climbing fiber to Purkinje cell wiring in GluRδ2 (GluD2) knockout mouse (2013)
  • Author(s): Miki H, Miyazaki T, Sakimura K, Watanabe M, Kitamura K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-12
• [Presentation] Selective strengthening of single climbing fiber inputs to Purkinje cell sduring postnatal cerebellar development In vivo (2013)
  • Author(s): Kawamura Y, Nakayama H, Hashimoto K, Sakimura K, Kitamura K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-11
• [Presentation] Global sealing-down of excitatory postsynaptic responses in cerebellar Purkinje cells specifically impairs the late phase of climbing fiber synapse elimination during postnatal development (2013)
  • Author(s): Kawata S, Miyazaki T, Yamazaki M, Mikuni T, Yamasaki M, Hahimoto K, Watanabe M, Sakimura K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-11
• [Presentation] Identification of retrograde signaling molecules required for developmental synapse elimination in the cerebellum by an RNAi-based approach (2013)
  • Author(s): Uesaka N, Mikuni T, Hirai H, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego ConventionCenter (San Diego, California, アメリカ)
  • Year and Date: 2013-11-11
• [Presentation] Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineur (2013)
  • Author(s): Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, California, アメリカ)
  • Year and Date: 2013-11-10
• [Presentation] Postnatal desynchronization of climbing fiber responses in Purkinje cell populations of the developing cerebellum (2013)
  • Author(s): Good J-M, Miyazaki T, Kitamura T, Watanabe M, Ssakimura K, Kano M
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, Caifornia, アメリカ)
  • Year and Date: 2013-11-09
• [Presentation] マウスバレル野第2/3層におけるスパースで不均一な感覚シナプス入力分布 (2013)
  • Author(s): 喜多村和郎, 狩野方伸
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-22
• [Presentation] サルにおける瞬目反射条件づけ : 筋電位測定法と高速イメージング法を用いた瞬目反射条件づけ方法の開発とその評価 (2013)
  • Author(s): 桐野豊, 山本茂幸, 鈴木一隆, 豊田晴義, 狩野方伸, 塚田秀夫
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-22
• [Presentation] Endocannnabinoid-Mediated Modulation of Inhibitory Synaptic Transmission to GABAergic and non-GABAergic Neurons in the Bed Nucleus of the Stria Terminal is (BNST) (2013)
  • Author(s): Kato A, Yanagawa Y, Kano M
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-21
• [Presentation] stargazin (TARP γ-2)の欠損による小脳プルキンエ細胞でのカルシウムシグナルの減弱により登上繊維刈り込みの後期過程が選択的に障害される (2013)
  • Author(s): 川田慎也, 橋本浩一, 三國貴康, 山崎真弥, 宮崎太輔, 山崎美和子, 渡辺雅彦, 﨑村建司, 狩野方伸
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-21
• [Presentation] 内因性カンナビノイド2アラキドノイルグリセロールは歯状回の興奮性シナプス伝達を抑制し発作を抑制する (2013)
  • Author(s): 菅谷佑樹, 山崎真弥, 﨑村建司, 狩野方伸
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-21
• [Presentation] マウス小脳皮質におけるaldolase C発現領域に相関した同期生の高い登上繊維応答 (2013)
  • Author(s): 堤新一郎, 多田真弓, 崎村建司, 喜多村和郎, 狩野方伸
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-20
• [Presentation] モノアシルグリセロールリパーゼ欠損マウスにおける海馬依存症記憶機能の包括的評価 (2013)
  • Author(s): 岸本泰司, Barbara Cagniard, 山崎真弥, 中山順子, 﨑村建司, 桐野豊, 狩野方伸
  • Organizer: 日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2013-06-20