| Budget Amount *help |
¥215,800,000 (Direct Cost: ¥166,000,000、Indirect Cost: ¥49,800,000)
Fiscal Year 2017: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2013: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
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| Outline of Final Research Achievements |
The Centromere is a genomic locus, which is essential for faithful chromosome segregation. In this research project, we tried to clarify molecular basis how the centromere is formed and how centromere functions are controlled during progression of the cell cycle. We performed following 3 projects: (1) Analyses of centromere assembly using chromosome engineering techniques (2) In vitro reconstitution of centromere protein complexes (3) Structural analyses of centromere protein complexes at atomic resolution. All projects were going well, and our achievements in these projects contribute to understanding of molecular basis for centromere formation and functions.
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