| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Biodegradable injectable polymers (IPs), which exhibit so-to-gel transition in response to temperature increase, are expected to be applied for biomedical materials such as drug delivery system or tissue engineering. In this study, we developed biodegradable IP systems showing powder morphology after freeze-drying and rapid solublization, to enable rapid on-site preparation of IP formulation at clinical scene. We then succeeded to provide IP formulation exhibiting sustained release of protein drug. On the other hand, previously reported biodegradable IP systems can easily go back to sol state in the presence much amount of water such as intraperitoneal space. To solve this problem, we also developed IP systems which exhibit irreversible gelation by covalent cross-liking after gelation in response to temperature increase. The IP systems showed longer duration of gel state in aqueous solution.
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