Development of three dimensional dose evaluation system using prompt gamma-ray for boron neutron capture therapy
| Project/Area Number |
25282155
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Tanaka Hiroki 京都大学, 原子炉実験所, 准教授 (70391274)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
櫻井 良憲 京都大学, 原子炉実験所, 准教授 (20273534)
川端 信司 大阪医科大学, 医学部, 講師 (20340549)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | ホウ素中性子捕捉療法 / リアルタイムホウ素濃度測定 / がん治療 / 線量評価システム / SPECT / 硼素中性子捕捉両方 / 線量評価 / 光ファイバー / 硼素中性子捕捉療法 |
|---|
| Outline of Final Research Achievements |
Generally, boron concentration is measured by the method of prompt gamma ray analysis in BNCT treatment. However, the information of boron concentration is not able to be obtained by this method during the treatment. It is desired to measure the boron concentration in real-time. Therefore, we propose the method using prompt gamma rays with the energy of 478 keV emitted by the reaction between boron-10 and thermal neutron. There are some agendas, which should be overcome in order to apply a prompt gamma rays imaging detector in BNCT irradiation field. Most important agenda is the discrimination from 511 keV annihilation gamma ray as back-ground. The energy resolution of less than 6.5 % FWHM at 511 keV is needed in order to discriminate 511 keV gamma ray.
We constructed a prompt gamma rays imaging detector consisting of LaBr3(Ce) scintillator, 8 x 8 MPPC arrays, 64 channel channels amplifier and ADC. It was confirmed that this system was able to discriminate 511 keV gamma ray.
|
Report
(5 results)
Research Products
(29 results)
-
[Journal Article] Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy2016
Author(s)
Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-ichiro Masunaga, Masahiro Hiraoka, Koji Ono, Minoru Suzuki, Mitsunori Kirihata
-
Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 859-868
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
[Presentation] Clinical results of reactor-based BNCT using BPA for the patients with recurrent malignant glioma2016
Author(s)
S. Kawabata, R. Hiramatsu, K. Takeuchi, H. Shiba, Y. Matsushita, T.Kuroiwa, H. Tanaka, Y. Sakurai, M. Suzuki, K. Ono, S.-I. Miyatake
Organizer
the 17th International Congress on Neutron Capture Therapy
Place of Presentation
Missiuri,USA
Year and Date
2016-10-02
Related Report
Int'l Joint Research
-
[Presentation] Development of a real-time prompt gamma-ray imaging system using GAGG:Ce or SrI2:Eu scintillator array for BNCT2016
Author(s)
H.Tanaka, Y. Sakurai, T. Takata, T. Watanabe, M. Suzuki, K. Akabori, S. Kawabata, S. Masunaga, N. Kondo, K. Ono, A. Maruhashi
Organizer
the 17th International Congress on Neutron Capture Therapy
Place of Presentation
Missiuri,USA
Year and Date
2016-10-02
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 微小シンチレータと石英ファイバーを用いた中性子モニターのBNCT照射場への適応2014
Author(s)
田中浩基,櫻井良憲,鈴木実,増永慎一郎,高田卓志,藤本望,仲川洋介,渡邉翼,近藤夏子,楢林正流,木梨友子,滝和也,小野公二,丸橋晃
Organizer
第11回日本中性子捕捉療法学会学術大会
Place of Presentation
大阪大学(大阪府吹田市)
Year and Date
2014-07-05 – 2014-07-06
Related Report
-
[Presentation] Study on the accelerator-based neutron source using Be(p,n) reaction with proton energy of lower than 30 MeV2014
Author(s)
Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Nozomi Fujimoto, Yuko Kinashi, Natsuko Kondo, Takushi Takata, Masaru Narabayashi, Tsubasa Watanabe, Akira Maruhashi and Koji Ono
Organizer
16th International Congress on Neutron Capture Therapy
Place of Presentation
Helsinki, Finland
Year and Date
2014-06-14 – 2014-06-19
Related Report
-
-
-
-
-
[Presentation] Study on the evaluation of 10B concentration using proton-induced prompt gamma ray analysis for BNCT2013
Author(s)
Hiroki Tanaka, Yoshinori Sakurai, Ryohei Uchida, Tokuhiro Kawamura, Tsubasa Watanabe, Minoru Suzuki,Hidetsugu Tsutida,Shinichiro Masunaga, Natsuko Kondo, Masaru Narabayashi,Koji Ono, Akira Maruhashi
Organizer
7th Young Researchers Boron Neutron Capture Therapy Meeting
Place of Presentation
スペイン、グラナダ
Related Report
-
-
-
