Neural mechanism and treatment of stress-induced myofascial pain
| Project/Area Number |
25282160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
Taguchi Toru 名古屋大学, 環境医学研究所, 講師 (90464156)
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| Co-Investigator(Renkei-kenkyūsha) |
KATANOSAKA KIMIAKI 中部大学, 生命健康科学部, 准教授 (50335006)
HAYASHI KOEI 名古屋大学, 環境医学研究所, 研究員 (00579592)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | ストレス / 痛み / 痛覚過敏 / 筋・筋膜性疼痛 / 線維筋痛症 / 疼痛関連イオンチャネル / 酸感受性イオンチャネル / 侵害受容器 / 筋・筋膜 / 神経機構 / 理学療法 / 脊髄 |
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| Outline of Final Research Achievements |
Myofascial pain such as stiff neck, low back pain, and fibromyalgia is frequent in our aging society, and it is deeply affected by physical and mental stress. Here in this study we clarified some molecular and neural mechanisms of stress-induced myofascial pain (SiMFP) using animal models. In a reserpine-induced fibromyalgia model, acid-sensing ion channel 3 expressing in peripheral nociceptive neurons and spinal microglia play pivotal roles in mechanical hyperalgesia. ASIC3 was found to be involved in exercise-induced myofascial pain by behavioral and electrophysiological experiments. These findings could be useful for the treatment of patients with SiMFP.
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Report
(4 results)
Research Products
(80 results)
