| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Outline of Final Research Achievements |
Three types of synthetic methods for the regioselectively fluorinated polycyclic aromatic hydrocarbons (F-PAHs) have been developed via Friedel-Crafts-type cyclizations by using electrophilic activation of fluoroalkenes with metal complexes or Lewis acids. When 1,1-difluoro-1-alkenes, 1,1,2-trifluoro-1-alkenes, 1,1-difluoroallenes, and 2-trifluoromethyl-1-alkenes were used as starting materials, the positions of C-C bond formation and fluorine introduction were perfectly controlled by α-cation stabilizing effect of fluorine substituents. Both of these synthetic methods for angular F-PAHs and linear F-PAHs are used in combination to fulfill our objective, systematic syntheses of regioselectively-fluorinated polycyclic aromatic hydrocarbons.
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