Development of novel catalysts inducing halogen bonding and its application for asymmetric synthesis.
Project/Area Number |
25288045
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Nagoya Institute of Technology |
Principal Investigator |
Norio Shibata 名古屋工業大学, 工学(系)研究科(研究院), 教授 (40293302)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | フッ素 / ハロゲン結合 / 試薬 / 電子吸引性 / 触媒 / フルオロアルキル / ヨウ素 / 結晶構造解析 / ペンタフルオロスルファニル / ラジカル反応 / トリフルオロメチル / ペンタフルオロフェニル |
Outline of Final Research Achievements |
The key for the development of novel molecules inducing halogen bonding is the introduction electron-deficient fluorinated functional group into the structures. Therefore I first studied the development of new reagents for fluoro-functionalized reagents. After investigation, we developed novel trifluoromethylthiolation reagent, pentafluorophenylation reagent, and pentafluorosulfanylphenyl reagent. In addition, I succeeded the design and synthesis of fluoro-functionalized phthalocyanines and subphthalocyanines. Furthermore, corresponding fluoro-functionalized subphthalocyanine shows the remarkable ability for catalytic trifluoromethylation under LED red light. Finally, I investigated the halogen-binding possibility of various compounds thoroughly and I found the novel catalyst for Mukaiyama-aldol reaction based on the halogen bonding.
|
Report
(4 results)
Research Products
(126 results)