Analytical System for Imaging Mass Spectrometry using Gold Nanoparticles as a Mass Probe
| Project/Area Number |
25288066
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
Niidome Yasuro 鹿児島大学, 学術研究院理工学域理学系, 准教授 (50264081)
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| Co-Investigator(Kenkyū-buntansha) |
Niidome Takuro 熊本大学, 大学院自然科学研究科, 教授 (20264210)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
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| Keywords | 金ナノロッド / 質量分析 / マスプローブ / 質量分析イメージング / イメージング質量分析 / 凝集状態制御 / ナノ材料 / ナノバイオ |
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| Outline of Final Research Achievements |
Liver tissue sections were prepared from mice in which gold nanorods were intravenously injected. Desorption of Gold ions from a 20 micrometer-thick section was possible. Imaging mass spectrometry of gold ions revealed the distribution of gold nanoparticles in tumor tissues of tumor-bearing mice. Gold nanoparticles were find in the areas where blood flow existed. It was found that gold nanorods acted as a mass probe in a living body.
Very sensitive detection of gold ions desorbed from polymer membranes was possible. However, large scale aggregation of nanoparticles suppressed the ionization/desorption of gold ions. Individually isolated gold nanorods were found to act as an efficient mass probe.
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Report
(4 results)
Research Products
(50 results)
