| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
The mRNA 3’ poly(A) tail length regulation plays central roles in the post-transcriptional control of gene expression. In this study, we aimed to verify novel regulatory mechanisms of gene expression targeting mRNA poly(A) tail and unraveled the whole picture of the following mechanisms: (i) negative regulation of gene expression by the shortening of the poly(A) tail of mRNA (e.g., c-myc and GluR2), (ii) positive regulation of gene expression by the lengthening of the poly(A) tail of mRNA (e.g., p27kip1, hnRNPA1 and b-catenin), and (iii) stress-induced global regulation of gene expression by the stabilization of mRNA poly(A) tail and formation of stress granules.
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