Evolution from fins into limbs
| Project/Area Number |
25291086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biodiversity/Systematics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Tanaka Mikiko 東京工業大学, 生命理工学研究科, 准教授 (40376950)
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| Co-Investigator(Kenkyū-buntansha) |
黒川 大輔 東京大学, 理学(系)研究科(研究院), 助教 (40342779)
村上 安則 愛媛大学, 理工学研究科, 准教授 (50342861)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 進化発生 / 形態進化 / 発生分化 / 進化 |
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| Outline of Final Research Achievements |
In this project, we aimed to explore the evolutionary process of how fins have evolved into limbs during evolution of vertebrates. Studies of catsharks revealed that there was a shift in the balance of anterior and posterior fileds in their fin buds compared to that in mouse limb buds. Furthermore, catshark genome lacked a sequence found in mice and other tetrapods, which is responsible for preventing Gli3 expression in the posterior part of tetrapod limb buds. When we deliberately “posteriorised” pectoral fin buds of catshark, the fins lost anterior skeletal elements, and showed a single bone connected to the pectoral girdle as seen in fossil Tiktaalik pectoral fins. We also explored the developmental mechanisms behind the alteration of the neuronal framework during morphological diversification of limbs and found that Sema3A-dependent guidance system plays a key role in this process.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] A shift in anterior-posterior positional information underlies the fin-to limb evolution.2015
Author(s)
Onimaru, K., Kuraku, S., Takagi, W., Hyodo, S., Sharpe, J. and Tanaka, M.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers.2014
Author(s)
Kurokawa, D., Ohmura, T., Sakurai, Y., Inoue, K., Suda, Y. and Aizawa, S.
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Journal Title
Developmental Biology
Volume: 387
Issue: 2
Pages: 203-213
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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