| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Analysis of the genome-wide SNP data suggested that the Polynesian ancestor came from Southeast Asia to Melanesia and mixed with indigenous Melanesian. The present-day Polynesian may have had obesity-risk alleles both from Southeast Asians and indigenous Melanesian.
Oleoylethanolamide (OEA), an appetite-suppressing mediator, is degraded by an integral membrane enzyme encoded by the fatty acid amide hydrolase (FAAH) gene. A previous study demonstrated that the activity of FAAH enzyme was influenced by a non-synonymous SNP (rs324420; Pro129Thr) in the FAAH gene. The FAAH activity was higher in peripheral blood T-lymphocytes obtained from subjects homozygous for rs324420-C (129Pro) than in those for rs324420-A (129Thr). In the present study, the rs324420-C allele was significantly associated with increase in BMI. Our results suggest that the efficient degradation of OEA caused by FAAH rs324420-C may lead to excessive food intake and significant weight gain in Oceanic populations.
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