Polymorphisms associated with obesity/lipid metabolism/carbohydrate metabolism in Oceanic populations
Project/Area Number |
25291103
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Physical anthropology
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Research Institution | The University of Tokyo (2014-2015) University of Tsukuba (2013) |
Principal Investigator |
Ohashi Jun 東京大学, 理学(系)研究科(研究院), 准教授 (80301141)
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Co-Investigator(Kenkyū-buntansha) |
Furusawa Takuro 京都大学, アジア・アフリカ地域研究研究科, 准教授 (50422457)
Nishida Nao 国立研究開発法人国立国際医療研究センター, 肝炎免疫研究センター, 上級研究員 (50456109)
Nakayama Kazuhiro 自治医科大学, 医学部, 講師 (90433581)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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Keywords | オセアニア / 肥満 / 脂質代謝 / 多様性 / 進化 / 自然選択 / 多型 / 移住 |
Outline of Final Research Achievements |
Analysis of the genome-wide SNP data suggested that the Polynesian ancestor came from Southeast Asia to Melanesia and mixed with indigenous Melanesian. The present-day Polynesian may have had obesity-risk alleles both from Southeast Asians and indigenous Melanesian. Oleoylethanolamide (OEA), an appetite-suppressing mediator, is degraded by an integral membrane enzyme encoded by the fatty acid amide hydrolase (FAAH) gene. A previous study demonstrated that the activity of FAAH enzyme was influenced by a non-synonymous SNP (rs324420; Pro129Thr) in the FAAH gene. The FAAH activity was higher in peripheral blood T-lymphocytes obtained from subjects homozygous for rs324420-C (129Pro) than in those for rs324420-A (129Thr). In the present study, the rs324420-C allele was significantly associated with increase in BMI. Our results suggest that the efficient degradation of OEA caused by FAAH rs324420-C may lead to excessive food intake and significant weight gain in Oceanic populations.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.2015
Author(s)
N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, T. Sasazuki, K. Tokunaga, and M. Mizokami
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Journal Title
Tissue Antigens
Volume: 5
Issue: 6
Pages: 406-412
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, (省略), Tokunaga K, and Mizokami M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e86449-e86449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan2014
Author(s)
Khudayberganova D, Sugiyama M, Masaki N, Nishida N, Mukaide M, Sekler D, Latipov R, Nataliya K, Dildora S, Sharapov S, Usmanova G, Raxmanov M, Musabaev E, Mizokami M
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Journal Title
PLoS One
Volume: 24;9
Issue: 3
Pages: e93011-e93011
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.2014
Author(s)
Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S; Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan
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Journal Title
J Mol Endocrinol
Volume: 52
Issue: 2
Pages: 145-158
DOI
Related Report
Peer Reviewed
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