| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Heterosis, found more than 100 years ago, is a genetic phenomenon essential for animal breeding. However, no causal gene for heterosis has been cloned in animals. Our previous QTL studies using wild mice revealed a small genomic region containing a overdominant QTL for heterosis of body weight. In this study, by an integration approach of phenotypic analysis, exome analysis, and transcriptome analysis using subcongenic mouse strains, I fine-mapped three QTLs for body weight, body length and white fat pad weight to 2.1- to 8.0-Mb genomic regions. Although none of the three QTLs exhibited heterotic effect, several differentially expressed genes were revealed as candidate genes for the body weight and fat weight QTLs.
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