Discovery of new reactions and utilities of 4-membered carbocyles based on their unique ring strains.
| Project/Area Number |
25293002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKASU KIYOSEI 京都大学, 薬学研究科(研究院), 教授 (10302168)
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Akira 京都大学, 大学院薬学研究科, 准教授 (50300893)
YAMAOKA Yousuke 京都大学, 大学院薬学研究科, 助教 (60624723)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 有機合成 / 分子ひずみ / シクロブタン / 中員環 / 天然物合成 / 機能性分子 / 反応開発 / シクロブテン / 生物活性天然物 / 不斉合成 / 四員環炭化水素 / 小員環 / 合成化学 / 触媒反応 |
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| Outline of Final Research Achievements |
Four-membered carbocyclic ring systems, including cyclobutanes and cyclobutenes, are one of fundamental and important structural units. Four-membered ring compounds are frequently found in natural and unnatural products displaying unique biological activities. In addition, cyclobutanes and cyclubutenes have been utilized as key intermediates in synthetic routes producing structurally complex targets because of their unique chemical transformation such as ring-opening and ring-expansion reactions. Despite their high utility, only a limited number of practical and efficient methods exist for their synthesis. We found several new chemistry of cyclobutanes, cyclobutenes and related substances. We also demonstrated its synthetic application to biologically active substances having 4-membered carbocyles.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Total Synthesis of Paesslerin A2015
Author(s)
Yuzo Mogi, Kazato Inanaga, Takayuki Ishii, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, Kiyosei Takasu
Organizer
The 39th Naito Conference「The chemistry of organocatalysts 有機分子触媒の化学」
Place of Presentation
シャトレーゼ ガトーキングダム サッポロ
Year and Date
2015-07-06
Related Report
Int'l Joint Research
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[Presentation] TOTAL SYNTHESIS OF PAESSLERIN A2014
Author(s)
Yuzo Mogi, Kazato Inanaga, Takayuki Ishii, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, Kiyosei Takasu
Organizer
8th Singapore International Chemistry Conference (SICC-8)
Place of Presentation
the University Town campus of NUS, Singapore
Year and Date
2014-12-14 – 2014-12-17
Related Report
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