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Molecular mechanisms linking lipid metabolism and thermoregulation

Research Project

Project/Area Number 25293012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

Umeda Masato  京都大学, 工学(系)研究科(研究院), 教授 (10185069)

Co-Investigator(Renkei-kenkyūsha) HARA Yuji  京都大学, 大学院工学研究科, 准教授 (60362456)
NAGAO Kohjiro  京都大学, 大学院工学研究科, 助教 (40587325)
JUNI Naoto  京都大学, 大学院工学研究科, 研究員 (90572199)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords脂質 / 細胞膜 / 温度 / 細胞・組織 / 昆虫 / シグナル伝達 / 代謝疾患
Outline of Final Research Achievements

Temperature is a universal and pervasive physical characteristic, which affects the physiology, behavior and evolution of organisms. Animals have thermoregulatory systems to adapt their physiological functions, such as energy utilization, growth, reproduction and locomotion, in response to the wide range of changes in ambient temperature. We have shown that thermoregulatory behavior of Drosophila melanogaster is highly dependent on the level of energy metabolism and identified that Δ-9 fatty acid desaturase (DESAT1), whose expression is highly dependent on environmental temperature, plays a pivotal role in controlling thermoregulatory behavior as well as lipid metabolism of Drosophila.
In this study, we elucidated the molecular mechanisms that regulate the expression of DESAT1 and identified the DESAT1-associated proteins. We also examined the effect of DESAT1 on mitochondrial function and the temperature-dependent control of body size.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Evaluation of aegerolysins as novel tools to detect and visualize ceramide phosphoethanolamine, a major sphingolipid in invertebrates2015

    • Author(s)
      Bhat HB, Ishitsuka R, Inaba T, Murate M, Abe M, Makino A, Kohyama-Koganeya A, Nagao K, Kurahashi A, Kishimoto T, Tahara M, Yamano A, Nagamune K, Hirabayashi Y, Juni N, Umeda M, Fujimori F, Nishibori K, Yamaji-Hasegawa A, Greimel P, Kobayashi T.
    • Journal Title

      FASEB J

      Volume: 29(9) Issue: 9 Pages: 3920-34

    • DOI

      10.1096/fj.15-272112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid.2015

    • Author(s)
      Rina Ogawa, Kohjiro Nagao, Kentaro Taniuchi, Masaki Tsuchiya, Utako Kato, Yuji Hara, Takehiko Inaba, Toshihide Kobayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Masato Umeda
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 7 Pages: e0131668-e0131668

    • DOI

      10.1371/journal.pone.0131668

    • NAID

      120005756258

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リン脂質フリッパーゼ-構造、リン脂質特異性、機能、疾患とのかかわり2014

    • Author(s)
      梅田真郷
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 1105-1112

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Journal Article] Curvature engineering: positive membrane curvature induced by epsin N-terminal peptide boosts internalization of octaarginine.2013

    • Author(s)
      Pujals S., Miyamae H., Afonin S., Murayama T., Hirose H., Nakase I., Taniuchi K., Umeda M., Sakamoto K., Ulrich AS., Futaki S.
    • Journal Title

      ACS Chem Biol.

      Volume: 8 Issue: 9 Pages: 1894-1899

    • DOI

      10.1021/cb4002987

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingomyelin clustering is essential for the formation of microvilli.2013

    • Author(s)
      Ikenouchi J, Hirata M, Yonemura S, Umeda M.
    • Journal Title

      Journal of Cell Science

      Volume: 126 Pages: 3585-3592

    • DOI

      10.1242/jcs.122325

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of nadrin, a Rho GTPase-activating protein, in the morphological differentiation of astrocytes2013

    • Author(s)
      Kobayashi, Y., Harada, A., Furuta, B., Asou, H., Kato, U., Umeda, M.:
    • Journal Title

      J Biochem

      Volume: 153 Issue: 4 Pages: 389-398

    • DOI

      10.1093/jb/mvt005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for phospholipid flippase complex of ATP8A1 and CDC50A in cell migration.2013

    • Author(s)
      Kato, U., Inadome, H., Emoto, K., Kobayashi, T., Umeda, M.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 7 Pages: 4922-4934

    • DOI

      10.1074/jbc.m112.402701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエと脂質研究2013

    • Author(s)
      山本真寿・従二直人・加藤詩子・梅田真郷
    • Journal Title

      遺伝子医学MOOK

      Volume: 24 Pages: 117-123

    • Related Report
      2013 Annual Research Report
  • [Presentation] 膜脂質ダイナミクスを介する細胞機能の制御機構2016

    • Author(s)
      梅田真郷
    • Organizer
      日本膜学会「第38年会」
    • Place of Presentation
      早稲田大学(東京)
    • Year and Date
      2016-05-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂質を介するエネルギー代謝と温度調節行動の制御機構2016

    • Author(s)
      梅田真郷
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体膜脂質と温度感受性システム2016

    • Author(s)
      梅田真郷
    • Organizer
      第36回白金シンポジウム
    • Place of Presentation
      北里大学薬学部(東京)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体膜におけるリン脂質分子の運動と機能2015

    • Author(s)
      梅田真郷
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(金沢)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 呼吸とエネルギー代謝:昆虫の秘密から学ぶ2015

    • Author(s)
      梅田真郷
    • Organizer
      第19回酵素ダイナミクス研究会
    • Place of Presentation
      東京女子医科大学(東京)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Asymmetric transbilayer distribution of membrane phospholipids is disrupted by constitutive activation of phospholipid scramblase in insect cells2015

    • Author(s)
      Masato Umeda
    • Organizer
      Lipids, Molecular & Cellular Biology of Gordon Research Conference
    • Place of Presentation
      Waterville Valley(USA)
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生物の温度応答と生体膜システムの関係2015

    • Author(s)
      梅田真郷
    • Organizer
      第59回生物医工学サロン
    • Place of Presentation
      京都大学再生医科学研究所(京都)
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生物のロバスト制御と脂質生物学2015

    • Author(s)
      梅田真郷
    • Organizer
      第57回日本脂質生化学会
    • Place of Presentation
      一橋大学一橋講堂(東京)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生物のロバスト制御と脂質生物学2015

    • Author(s)
      梅田真郷
    • Organizer
      第57回日本脂質生化学会
    • Place of Presentation
      東京・一橋大学一橋講堂
    • Year and Date
      2015-05-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脂質の比較生物学2015

    • Author(s)
      梅田真郷
    • Organizer
      第1回 Integrated Lipidology Meeting
    • Place of Presentation
      静岡・日本平ホテル
    • Year and Date
      2015-02-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 昆虫のユニークな膜脂質と脂質代謝機構2014

    • Author(s)
      梅田真郷
    • Organizer
      スフィンゴセラピ研究会
    • Place of Presentation
      加賀・山中温泉河鹿荘ロイヤルホテル
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエのユニークな膜構築と脂質代謝機構

    • Author(s)
      梅田真郷
    • Organizer
      2014年日本農芸化学会大会
    • Place of Presentation
      明治大学、川崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体膜におけるリン脂質分子種の非対称分布

    • Author(s)
      石川真実、加藤詩子、芦本徹、井上飛鳥、青木淳賢、梅田真郷
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエにおけるミトコンドリアへの新規脂肪酸輸送機構の解析

    • Author(s)
      石井隆太、従二直人、加藤詩子、梅田真郷
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエのユニークな膜脂質とその動態に関する研究

    • Author(s)
      加藤詩子、横田展大、石井隆太、山本真寿、梅田真郷
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      ホテル松島大観荘
    • Related Report
      2013 Annual Research Report
  • [Book] レーニンジャーの新生化学6版(翻訳)2015

    • Author(s)
      梅田真郷
    • Total Pages
      40
    • Publisher
      廣川書店
    • Related Report
      2014 Annual Research Report
  • [Book] 梅田真郷編「生体膜の分子機構-リピッドワールドが先導する生命科学」2014

    • Author(s)
      梅田真郷
    • Total Pages
      38
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学大学院工学研究科梅田研究室

    • URL

      http://www.sbchem.kyoto-u.ac.jp/umeda-lab/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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