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Sleepiness and l-carnitine: mechanism of action and clinica efficacyl-carnitine

Research Project

Project/Area Number 25293056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

HONDA Makoto  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (50370979)

Co-Investigator(Kenkyū-buntansha) 児玉 亨  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords脂肪酸代謝 / カルニチン / ナルコレプシー / 睡眠脳波 / 脂質代謝 / 夜間睡眠 / 脳神経疾患 / 睡眠
Outline of Final Research Achievements

Sleepiness and L-carnitine: mechanism of action and clinical efficacy
We previously report the favorable effect of L-carnitine on the sleepiness of narcolepsy patients. We tried to address the mechanism and correlates of the efficacy of L-carnitine using animal model and objective measure on clinical study. L-carnitine improved CPT1 activity marker in brain and peripheral, and altered gene expression and metabolome such as dopamine and related genes. Sleep in narcolepsy-model mice actually improved during resting (light) period. About 40% of hypersomnia can benefit from L-carnitine. We tried to discriminate the L-carnitine responders in hypersomnia patients using clinical symptoms or EEG measures.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014 Other

All Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Remarks (1 results)

  • [Presentation] Sweet seeking and sleep stability in narcolepsy pateints.2017

    • Author(s)
      Honda M, Ito W,Ueno T, Kato N, Miyagawa T
    • Organizer
      1st Asian Narcolepsy & Hypersomnolence Society Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] REM transition index (# sleep stage transitions from REM/REM duration) correlates with subjective nocturnal awakenings and is an independent risk factor for Narcolepsy Type12016

    • Author(s)
      Honda M, Sasaki K, Ueno T, Ito W, Kato N
    • Organizer
      Sleep 2016
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of L-carnitine on narcolepsy2016

    • Author(s)
      Honda M
    • Organizer
      8th Asian Narcolepsy Forum/ 4th International Pediatric Sleep Association Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナルコレプシーにおける脂肪酸代謝異常とLカルニチンの効2015

    • Author(s)
      本多 真
    • Organizer
      第40回日本睡眠学会学術集会
    • Place of Presentation
      栃木県総合文化センター(栃木県・宇都宮市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 過眠を呈する睡眠障害の症状と病態2015

    • Author(s)
      本多 真
    • Organizer
      つくばアカデミー・オブ・サイカイアトリー学術講演会
    • Place of Presentation
      秋葉原UDXカンファレンス南ウイング(東京都千代田区)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] CPT1 activity is a risk factor for narcolepsy: possible contribution of dietary habit2015

    • Author(s)
      Honda M
    • Organizer
      World Association of Sleep Medicine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Decreased CPT1 function is associated with and a risk factor for narcolepsy and essential hypersomnia.2014

    • Author(s)
      Honda M, Miyagawa T, Shigematsu Y, Kodama T, Tokunaga K.
    • Organizer
      Eeuropean Sleep Research Soceity, congress 2014
    • Place of Presentation
      Tallinn, Estonia
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナルコレプシーの症状と病態2014

    • Author(s)
      本多真
    • Organizer
      第6回ISMSJ学術集会
    • Place of Presentation
      神戸ファッションマート, 兵庫県神戸市
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Low long-chain acylcarnitines in narcolepsy.

    • Author(s)
      Honda M, Miyagawa T, Shigematsu Y, Tokunaga K
    • Organizer
      11th WFSBP
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Decreased long chain acylcarnitines in narcolepsy

    • Author(s)
      Honda M, Miyagawa T, Shigematsu Y, Tokunaga K
    • Organizer
      Sleep2013
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナルコレプシー治療の変遷:過眠症状とその治療

    • Author(s)
      本多真
    • Organizer
      第38回日本睡眠学会学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所 睡眠プロジェクト

    • URL

      http://www.igakuken.or.jp/sleep/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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