Sleepiness and l-carnitine: mechanism of action and clinica efficacyl-carnitine
| Project/Area Number |
25293056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HONDA Makoto 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (50370979)
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| Co-Investigator(Kenkyū-buntansha) |
児玉 亨 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 脂肪酸代謝 / カルニチン / ナルコレプシー / 睡眠脳波 / 脂質代謝 / 夜間睡眠 / 脳神経疾患 / 睡眠 |
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| Outline of Final Research Achievements |
Sleepiness and L-carnitine: mechanism of action and clinical efficacy
We previously report the favorable effect of L-carnitine on the sleepiness of narcolepsy patients. We tried to address the mechanism and correlates of the efficacy of L-carnitine using animal model and objective measure on clinical study. L-carnitine improved CPT1 activity marker in brain and peripheral, and altered gene expression and metabolome such as dopamine and related genes. Sleep in narcolepsy-model mice actually improved during resting (light) period. About 40% of hypersomnia can benefit from L-carnitine. We tried to discriminate the L-carnitine responders in hypersomnia patients using clinical symptoms or EEG measures.
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Report
(5 results)
Research Products
(12 results)
