| Project/Area Number |
25293062
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
INUI Makoto 山口大学, 医学(系)研究科(研究院), 教授 (70223237)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAMIMURA Akio 山口大学, 大学院医学系研究科, 教授 (30194971)
KURAMASU Atsuo 山口大学, 大学院医学系研究科, 准教授 (90302091)
HONDA Takeshi 山口大学, 大学院医学系研究科, 講師 (30457311)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAMBA Keiichi 大阪大学, 大学院生命機能研究科, 教授 (30346142)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Keywords | 心不全治療薬 / ホスホランバン / アプタマー / 創薬 / 結晶構造解析 |
|---|
| Outline of Final Research Achievements |
In the failing heart, the Ca2+ pumping activity of the intracellular Ca2+ storage site, the sarcoplasmic reticulum (SR), is significantly reduced, resulting in dysfunction of cardiomyocytes due to intracellular Ca2+ overload. The Ca2+ pumping activity of SR is regulated by phospholamban, which is a potential target to the treatment of heart failure. Here we studied a phospholamban inhibitor which augments the Ca2+ pumping activity of SR, including a phospholamban aptamer. Our results including optimization of a phospholamban aptamer provide a basis for the development of new therapeutic agents for heart failure.
|
