| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
In the vertebrate retina, visual information is transmitted from photoreceptor cells to ganglion cells via bipolar cells. The photoreceptor axon terminal forms a specialized synaptic structure, the ribbon synapse, which specifically connects photoreceptor axonal terminals with bipolar and horizontal cell dendritic terminals in the outer plexiform layer. Although various presynaptic proteins which are required for synaptic ribbon structure, such as Ctbp2, piccolo and bassoon, have been identified, the mechanism of ribbon synapse apposition specific to bipolar and horizontal terminals remains mostly unknown. We investigated molecular mechanisms underling the proper formation of photoreceptor ribbon synapses.
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