Elucidation of the mechanism of neoatherosclerosis

• Project/Area Number: 25293182
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: KIMURA Takeshi 京都大学, 医学(系)研究科(研究院), 教授 (80359786)
• Co-Investigator(Kenkyū-buntansha): ONO Koh 京都大学, 大学院医学研究科, 准教授 (00359275) ; NISHI Eiichiro 京都大学, 大学院医学研究科, 准教授 (30362528) ; SHIOI Tetsuo 京都大学, 大学院医学研究科, 講師 (50360095) ; MAKIYAMA Takeru 京都大学, 大学院医学研究科, 助教 (30528302) ; SAITO Naritatsu 京都大学, 大学院医学研究科, 助教 (20467484) ; IMAI Masao 京都大学, 大学院医学研究科, 助教 (10625677)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 動脈硬化 / ステント / 血栓 / 狭心症 / 心筋梗塞 / neoatherosclerosis

Outline of Final Research Achievements

Percutaneous coronary intervention using coronary stent is a standard therapy for ischemic heart disease. Restenosis after stent implantation is dramatically reduced by the development of drug eluting stent. However, very late stent thrombosis and late catch-up phenomenon, which is the restenosis several years after treatment, are still remained as serious problems. Recently, neoatherosclerosis is receiving research attention for the cause of such conditions. We performed clinical and basic research to contribute the elucidation of the mechanism of neoatherosclerosis.

Research Products

• [Journal Article] Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes. (2016)
  • Author(s): Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 19111-19111
  • DOI: 10.1038/srep19111
  • NAID: 120005756304
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Duration of Prehospital Resuscitation Efforts After Out-of-Hospital Cardiac Arrest. (2016)
  • Author(s): Nagao K, Nonogi H, Yonemoto N, Gaieski DF, Ito N, Takayama M, Shirai S, Furuya S, Tani S, Kimura T, Saku K; Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group*.
  • Journal Title: Circulation Volume: 133 Issue: 14 Pages: 1386-96
  • DOI: 10.1161/circulationaha.115.018788
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis. (2016)
  • Author(s): Stone GW, Gao R, Kimura T, Kereiakes DJ, Ellis SG, Onuma Y, Cheong WF, Jones-McMeans J, Su X, Zhang Z, Serruys PW.
  • Journal Title: Lancet Volume: 387 Issue: 10025 Pages: 1277-89
  • DOI: 10.1016/s0140-6736(15)01039-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy (2016)
  • Author(s): Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
  • Journal Title: Cardiovascular Research Volume: 109 Issue: 1 Pages: 162-173
  • DOI: 10.1093/cvr/cvv248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Age and Sex on Clinical Outcomes after Percutaneous Coronary Intervention Relative to Coronary Artery Bypass Grafting in Patients with Triple Vessel Coronary Artery Disease. (2016)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Nakatsuma K, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Onodera T, Watanabe H, Natsuaki M, Sakata R, Hanyu M, Nishiwaki N, Komiya T, Kimura T.
  • Journal Title: Circulation Volume: 115 Issue: 19 Pages: 020955-020955
  • DOI: 10.1161/circulationaha.115.020955
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial. (2016)
  • Author(s): Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, et al.
  • Journal Title: European Heart Journal. Volume: 7 Issue: 7 Pages: 610-618
  • DOI: 10.1093/eurheartj/ehv501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A randomized trial evaluating everolimus-eluting Absorb bioresorbable scaffolds vs. everolimus-eluting metallic stents in patients with coronary artery disease: ABSORB Japan. (2015)
  • Author(s): Kimura T, Kozuma K, Tanabe K, Nakamura S, Yamane M, Muramatsu T, Saito S, Yajima J, Hagiwara N, Mitsudo K, Popma JJ, Serruys PW, Onuma Y, Ying S, Cao S, Staehr P, Cheong WF, Kusano H, Stone GW; ABSORB Japan Investigators.
  • Journal Title: Eur Heart J. Volume: 36 Issue: 47 Pages: 3332-42
  • DOI: 10.1093/eurheartj/ehv435
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting metallic stents: a meta-analysis of randomised controlled trials. (2015)
  • Author(s): Cassese S, Byrne RA, Ndrepepa G, Kufner S, Wiebe J, Repp J, Schunkert H, Fusaro M, Kimura T, Kastrati A.
  • Journal Title: Lancet Volume: 387 Issue: 10018 Pages: 537-544
  • DOI: 10.1016/s0140-6736(15)00979-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Atherosclerosis. Volume: 242(2) Issue: 2 Pages: 632-8
  • DOI: 10.1016/j.atherosclerosis.2015.05.010
  • NAID: 120005678183
  • Peer Reviewed / Open Access
• [Journal Article] Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial. (2015)
  • Author(s): Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, et al.
  • Journal Title: European Heart Journal. Volume: 7 Pages: 3276-3287
  • DOI: 10.1093/eurheartj/ehv457
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery. (2015)
  • Author(s): Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
  • Journal Title: PLoS One. Volume: 10(11) Issue: 11 Pages: e0142904-e0142904
  • DOI: 10.1371/journal.pone.0142904
  • NAID: 120005749912
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-33a/b in Lipid Metabolism (2015)
  • Author(s): Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 278-284
  • DOI: 10.1253/circj.CJ-14-1252
  • NAID: 130004927073
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Five-Year Outcome of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Triple-Vessel Coronary Artery Disease (from the Coronary Revascularization DemonstratingOutcome Study in Kyoto PCI/CABG Registry Cohort-2). (2015)
  • Author(s): Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Tazaki J, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T,Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 1 Pages: 59-65
  • DOI: 10.1016/j.amjcard.2015.03.040
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Initial Surgical Versus Conservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis. (2015)
  • Author(s): Taniguchi T, Morimoto T, Shiomi H et al.
  • Journal Title: J Am Coll Cardiol. Volume: 66 Issue: 25 Pages: 2827-38
  • DOI: 10.1016/j.jacc.2015.10.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meta-analysis of long-term clinical outcomes of everolimus-eluting stents. (2015)
  • Author(s): Toyota T, Shiomi H, Morimoto T, Kimura T.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 2 Pages: 187-94
  • DOI: 10.1016/j.amjcard.2015.03.059
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: observations from the CREDO-Kyoto Registry Cohort-2. (2015)
  • Author(s): Watanabe H, Morimoto T, Natsuaki M, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Horie M, et ai.
  • Journal Title: PLoS One Volume: 10(4) Issue: 4 Pages: e0124314-e0124314
  • DOI: 10.1371/journal.pone.0124314
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical efficacy of thrombus aspiration on 5-year clinical outcomes in patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention. (2015)
  • Author(s): Watanabe H, Shiomi H, Nakatsuma K et al.
  • Journal Title: J Am Heart Assoc. Volume: 4 Issue: 11
  • DOI: 10.1161/jaha.115.001945
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Influence of Sex on Long-Term Outcomes Afte Implantation of Bare-Metal Stent: A Multicenter Report From the Coronary Revascularization Demonstrating Outcome Study-Kyoto (CREDO-Kyoto) Registry Cohort-1. (2015)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Kato M, Takatsu Y, Doi O, Kambara H, Suwa S, Onodera T, Watanabe H, Natsuaki M, Kimura T
  • Journal Title: Circulation. Volume: 132 Issue: 24 Pages: 2323-33
  • DOI: 10.1161/circulationaha.115.017168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vitro assessment of physiological impact of recipient artery intervention on the contralateral donor artery. (2015)
  • Author(s): Watanabe H, Saito N, Matsuo H, Kawase Y, Watanabe S, Bao B, Yamamoto E, Higami H, Nakatsuma K, Kimura T.
  • Journal Title: Cardiovasc Revasc Med. Volume: 16 Pages: 90-100
  • Open Access / Acknowledgement Compliant
• [Journal Article] Relationships between nutritional status and markers of congestion in patients with pulmonary arterial hypertension. (2015)
  • Author(s): Kawamoto A, Kato T, Minamino-Muta E, Okano Y, Shioi T, Kimura T.
  • Journal Title: Int J Cardiol. Volume: 187 Pages: 27-28
  • DOI: 10.1016/j.ijcard.2015.03.354
  • NAID: 120006305980
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy (2015)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 4 Pages: 839-846
  • DOI: 10.1253/circj.CJ-14-1148
  • NAID: 130005130261
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Five-Year Outcomes of Percutaneous Versus Surgical Coronary Revascularization in PatientsWith Diabetes Mellitus (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). (2015)
  • Author(s): Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Am J Cardiol. Volume: 115 Issue: 8 Pages: 1063-72
  • DOI: 10.1016/j.amjcard.2015.01.544
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intravascular ultrasound observation of an obstruction of the left main coronary artery caused by displaced leaflet calcification and hematoma after transcatheter aortic valve implantation. (2015)
  • Author(s): Taniguchi T, Saito N, Minakata K, Imai M, Watanabe H, Toyota T, Watanabe S, Tazaki J, Koizumi S, Hirao S, Yamazaki K, Daijo H, Sakata R, Kimura T
  • Journal Title: Circulation Volume: 131 Issue: 7
  • DOI: 10.1161/circulationaha.114.014690
  • Peer Reviewed / Open Access
• [Journal Article] The organ-protective effect of N-type Ca(2+) channelblockade. (2015)
  • Author(s): Kuwahara K, Kimura T.
  • Journal Title: Pharmacol Ther. Volume: 15 Pages: 00045-5
  • DOI: 10.1016/j.pharmthera.2015.02.001
  • NAID: 120005663276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure (2015)
  • Author(s): Kawamoto A, Kato T, Shioi T, Okuda J, Kawashima T. Tamaki Y, Niizuma S, Tanada Y, Takemura G, Narazaki M, Matsuda T, Kimura T
  • Journal Title: PLoS One. Volume: 10 Issue: 1 Pages: e0117091-e0117091
  • DOI: 10.1371/journal.pone.0117091
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of radiofrequency catheter ablation of persistent atrial fibrillation on the left atrial function: assessment by 320-row multislice computed tomography. (2015)
  • Author(s): Hanazawa K, Kaitani K, Hayama Y, Onishi N, Tamaki Y, Miyake M, Kondo H,Tamura T, Izumi C, Shizuta S, Kimura T, Nakagawa Y.
  • Journal Title: Int J Cardiol. Volume: 179 Pages: 449-54
  • DOI: 10.1016/j.ijcard.2014.11.103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. (2015)
  • Author(s): Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
  • Journal Title: Circulation Research Volume: 116 Issue: 2 Pages: 279-288
  • DOI: 10.1161/circresaha.116.304707
  • Peer Reviewed
• [Journal Article] Outcomes of everolimus-eluting stent incomplete stent apposition: a serial optical coherence tomography analysis (2015)
  • Author(s): Shimamura, K
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 16 Issue: 1 Pages: 23-28
  • DOI: 10.1093/ehjci/jeu174
  • Peer Reviewed
• [Journal Article] Cost analysis of non-invasive fractional flow reserve derived from coronary computed tomographic angiography in Japan. (2015)
  • Author(s): Kimura T, Shiomi H, Kuribayashi S, Isshiki T, Kanazawa S, Ito H, Ikeda S, Forrest B, Zarins CK, Hlatky MA, Norgaard BL.
  • Journal Title: Cardiovasc Interv Ther. Volume: 30 Issue: 1 Pages: 38-44
  • DOI: 10.1007/s12928-014-0285-1
  • NAID: 40020374211
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of Statin Therapy on Cardiovascular Outcomes after Coronary Revascularization in Patients over 80 Years of Age (2014)
  • Author(s): Natsuaki M, Morimoto T, Furukawa Y, Shiomi H, Ono K, Kimura T
  • Journal Title: Atherosclerosis Volume: 237 Issue: 2 Pages: 821-828
  • DOI: 10.1016/j.atherosclerosis.2014.10.108
  • Peer Reviewed / Open Access
• [Journal Article] Association of localized hypersensitivity and in-stent neoatherosclerosis with the very late drug-eluting stent thrombosis. (2014)
  • Author(s): Yamaji K, Kubo S, Inoue K, Kadota K, Kuramitsu S, Shirai S, Ando K, Nobuyoshi M, Mitsudo K, Kimura T.
  • Journal Title: PLoS One. Volume: 25 Issue: 11 Pages: e113870-e113870
  • DOI: 10.1371/journal.pone.0113870
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serofendic acid protects against myocardial ischemia-reperfusion injury in rats. (2014)
  • Author(s): Ioroi T, Akao M, Iguchi M, Kato M, Kimura T, Izumi Y, Akaike A, Kume T.
  • Journal Title: J Pharmacol Sci. Volume: 126 Pages: 274-80
  • NAID: 130004704280
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice (2014)
  • Author(s): Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e108201-e108201
  • DOI: 10.1371/journal.pone.0108201
  • NAID: 120005496630
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Pre-infarction Angina Pectoris on Long-term Survival in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (2014)
  • Author(s): Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T.
  • Journal Title: Am J Cardiol Volume: 114 Issue: 8 Pages: 1179-1186
  • DOI: 10.1016/j.amjcard.2014.07.038
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of five-year outcomes of coronary artery bypass grafting versus percutaneous coronary intervention in patients with left ventricular ejection fractions≤50% versus >50% (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). (2014)
  • Author(s): Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Am J Cardiol. Volume: 114 Issue: 7 Pages: 988-96
  • DOI: 10.1016/j.amjcard.2014.07.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. (2014)
  • Author(s): Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
  • Journal Title: Cardiovasc Research Volume: 104 Issue: 1 Pages: 183-193
  • DOI: 10.1093/cvr/cvu185
  • NAID: 120005619790
  • Peer Reviewed / Open Access
• [Journal Article] Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention (2014)
  • Author(s): Tokushige A, Shiomi H, Morimoto T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Hamasaki S, Ohishi M, Nakashima H et al.
  • Journal Title: Circ Cardiovasc Interv. Volume: 7 Issue: 4 Pages: 482-491
  • DOI: 10.1161/circinterventions.113.001056
  • Peer Reviewed / Open Access
• [Journal Article] Predictive Performance of SYNTAX Score II in Patients With Left Main and Multivessel Coronary Artery Disease-analysis of CREDO-Kyoto registry. (2014)
  • Author(s): Campos CM, van Klaveren D, Iqbal J, Onuma Y, Zhang YJ, Garcia-Garcia HM, Morel MA, Farooq V, Shiomi H, Furukawa Y, Nakagawa Y, Kadota K, Lemos PA, Kimura T, Steyerberg EW, Serruys PW.
  • Journal Title: Circ J. Volume: 78 Pages: 1942-9
  • NAID: 130004926990
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of Long-term Mortality After Acute Myocardial Infarction Treated by Percutaneous Coronary Intervention in Patients Living Alone versus Not Living Alone at the Time of Hospitalization (2014)
  • Author(s): Nakatsuma K, Shiomi H, Watanabe H, Morimoto T, Taniguchi T, Toyota T, Furukawa Y, Nakagawa Y, Horie M, Kimura T
  • Journal Title: Am J Cardiol. Volume: 114 Issue: 4 Pages: 522-527
  • DOI: 10.1016/j.amjcard.2014.05.029
  • NAID: 120005469579
  • Peer Reviewed / Open Access
• [Journal Article] Percutaneous coronary intervention versus coronary artery bypass grafting in patients with end-stage renal disease requiring dialysis (5-year outcomes of the CREDO-Kyoto PCI/CABG Registry Cohort-2). (2014)
  • Author(s): Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Am J Cardiol. Volume: 114 Issue: 4 Pages: 555-61
  • DOI: 10.1016/j.amjcard.2014.05.034
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 5312-5312
  • DOI: 10.1038/srep05312
  • Peer Reviewed / Open Access
• [Journal Article] Relation of Contrast-Induced Nephropathy to Long-Term Mortality after Percutaneous Coronary Intervention (2014)
  • Author(s): Abe M, Morimoto T, Akao M, Furukawa Y, Nakagawa Y, Shizuta S, Ehara N, Taniguchi R, Doi T, Nishiyama K, Ozasa N, Saito N, Hoshino K, Mitsuoka H, Toma M, Tamura T, Haruna Y, Kita T, Kimura T.
  • Journal Title: Am J Cardiol. Volume: 114 Issue: 3 Pages: 362-368
  • DOI: 10.1016/j.amjcard.2014.05.009
  • Peer Reviewed / Open Access
• [Journal Article] Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention (2014)
  • Author(s): Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Tahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, et al.
  • Journal Title: Am J Cardiol Volume: 114 Issue: 1 Pages: 70-78
  • DOI: 10.1016/j.amjcard.2014.03.060
  • Peer Reviewed / Open Access
• [Journal Article] AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions. (2014)
  • Author(s): Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M. and Ashida, N.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 5094-5094
  • DOI: 10.1038/srep05094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome: mortality and major bleeding in a single-center registry. (2014)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circ J. Volume: 78 Pages: 1628-35
  • NAID: 130004926956
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term clinical outcomes after everolimus- and sirolimus-eluting coronary stent implantation: final 3-year follow-up of the randomized evaluation of sirolimus-eluting versus everolimus-eluting stent trial. (2014)
  • Author(s): Shiomi H, Kozuma K, Morimoto T, Igarashi K, Kadota K, Tanabe K, Morino Y, Akasaka T, Abe M, Suwa S, Muramatsu T, Kobayashi M, Dai K, Nakao K, Uematsu M, Tarutani Y, Fujii K, Simonton CA, Kimura T; RESET Investigators.
  • Journal Title: Circ Cardiovasc Interv. Volume: 7 Issue: 3 Pages: 343-54
  • DOI: 10.1161/circinterventions.113.001322
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Late adverse events after implantation of sirolimus-eluting stent and bare-metal stent: long-term (5-7 years) follow-up of the coronary revascularization demonstrating outcome study-kyoto registry cohort-2. (2014)
  • Author(s): Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Kato M, Suwa S, Takizawa A, Takatsu Y, Kita T, Kimura T
  • Journal Title: Circ Cardiovasc Interv. Volume: 7 Issue: 2 Pages: 168-79
  • DOI: 10.1161/circinterventions.113.000987
  • Peer Reviewed
• [Journal Article] Critical roles of nardilysin in the maintenance of body temperature homeostasis (2014)
  • Author(s): Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, Nishi K, Sakamoto J, Chen Po-Min, Inoue K, Fushiki T, Kita T, Kimura T and Nishi E
  • Journal Title: Nat. Commun Volume: 5 Issue: 1 Pages: 3224-3224
  • DOI: 10.1038/ncomms4224
  • Peer Reviewed / Open Access
• [Journal Article] Nardilysin prevents amyloid plaque formation by enhancing a-secretase activity in an Alzheimer's disease mouse model (2014)
  • Author(s): Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T and Nishi E
  • Journal Title: Neurobiol Aging Volume: 35 Issue: 1 Pages: 213-22
  • DOI: 10.1016/j.neurobiolaging.2013.07.014
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNAs and Lipoprotein Metabolism. (2014)
  • Author(s): Horie T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T, Ono K.
  • Journal Title: J Atheroscler Thromb. Volume: 21 Pages: 17-22
  • NAID: 130004845461
  • Peer Reviewed
• [Journal Article] Myocardial expression level of neural cell adhesion molecule correlates with reduced left ventricular function in human cardiomyopathy (2014)
  • Author(s): Nagao K, Sowa N, Inoue K, Tokunaga M, Fukuchi K, Uchiyama K, Ito H, Hayashi F, Makita T, Inada T, Tanaka M, Kimura T, and Ono K
  • Journal Title: Circulation; Heart Failur Volume: 7 Issue: 2 Pages: 351-8
  • DOI: 10.1161/circheartfailure.113.000939
  • Peer Reviewed
• [Journal Article] Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent: a randomized, controlled, noninferiority trial. (2013)
  • Author(s): Natsuaki M, Kozuma K, Morimoto T, Kadota K, Muramatsu T, Nakagawa Y, Akasaka T, Igarashi K, Tanabe K, Morino Y, Ishikawa T, Nishikawa H, Awata M, Abe M, Okada H, Takatsu Y, Ogata N, Kimura K, Urasawa K, Tarutani Y, Shiode N, Kimura T; NEXT Investigators.
  • Journal Title: J Am Coll Cardiol. Volume: 62 Issue: 20 Pages: 181-90
  • DOI: 10.1001/jama.2014.3584
  • Peer Reviewed
• [Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. (2013)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
  • Journal Title: Nat Commun. Volume: 4:2883 Issue: 1 Pages: 2883-2883
  • DOI: 10.1038/ncomms3883
  • NAID: 120005349007
  • Peer Reviewed / Open Access
• [Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice (2013)
  • Author(s): Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
  • Journal Title: PLoS ONE Volume: 8 Issue: 8 Pages: e72173-e72173
  • DOI: 10.1371/journal.pone.0072173
  • Peer Reviewed
• [Journal Article] Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture. (2013)
  • Author(s): Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T.
  • Journal Title: Circ J. Volume: 77 Pages: 1307-14
  • NAID: 10031151395
  • Peer Reviewed
• [Journal Article] Long Term Follow-up of a Pediatric Cohort with Short QT Syndrome. (2013)
  • Author(s): Villafane J, Atallah J,Horie M, et al.
  • Journal Title: J Am Coll Cardiol. Volume: 61(11) Issue: 11 Pages: 1183-91
  • DOI: 10.1016/j.jacc.2012.12.025
  • Peer Reviewed
• [Journal Article] Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple-vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2. (2013)
  • Author(s): Tazaki J, Shiomi H, Morimoto T, Imai M, Yamaji K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators.
  • Journal Title: EuroIntervention. Volume: 9 Issue: 4 Pages: 437-45
  • DOI: 10.4244/eijv9i4a72
  • Peer Reviewed
• [Presentation] High-density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in Japanese Patients after Percutaneous Coronary Intervention from the CREDO-Kyoto Registry Cohort-2. (2016)
  • Author(s): Izuhara M.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター外（仙台市）
  • Year and Date: 2016-03-18
• [Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway. (2016)
  • Author(s): Ono K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター外（仙台市）
  • Year and Date: 2016-03-18
• [Presentation] CREDO-Kyoto PCI/CABG Registry Cohort-2Investigators. High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: A report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T.
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida（USA）
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Reappraisal of antithrombotic-regimen in patients with atrial fibrillation after drug-eluting stent implantation. When to skip aspirin? Look back on the case-experience. (2015)
  • Author(s): Toyota T.
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida（USA）
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Session IV. DES Thrombosis and Restenosis. (2015)
  • Author(s): Kimura T.
  • Organizer: TCT 2015
  • Place of Presentation: Orlando, Florida（USA）
  • Year and Date: 2015-10-11
  • Int'l Joint Research
• [Presentation] Plenary Session VII. First Report Investigations. (2015)
  • Author(s): Kimura T.
  • Organizer: TCT 2015
  • Place of Presentation: Orlando, Florida（USA）
  • Year and Date: 2015-10-11
  • Int'l Joint Research
• [Presentation] Successful Percutaneous Closure of Large and Maialigment Atrial Septal Defects with Plumonary Hypertension. (2015)
  • Author(s): Imai M, Watanabe S, Toyoda T, Kimura T.
  • Organizer: CSI 2015
  • Place of Presentation: Frankfrut（Germany）
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] ABSORB Japan. 12-month clinical and 13-month angiographic outcomes from a randomized trial evaluating the Absorb Bioresorbable Vascular Scaffold vs_ metallic DES in de novo native coronary artery lesions. (2015)
  • Author(s): Kimura T.
  • Organizer: ESC CONGRESS 2015
  • Place of Presentation: London（UK）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Clinical impact of chronic total occlusion in non-infarct-related artery on long-term clinical outcomes in patients with multi-vessel disease undergoing primary PCI for ST-elevation acute myocardial infarction (from the CREDO-Kyoto AMIregistry). (2015)
  • Author(s): Watanabe H, Shiomi H, Kimura T.
  • Organizer: ESC CONGRESS 2015
  • Place of Presentation: London（UK）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Short versus prolonged dual antiplatelet therapy (DAPT) duration after coronary stent implantation: a comparison between the DAPT trial and 9 other trials evaluating DAPT duration. (2015)
  • Author(s): Toyota T, Shiomi H, Morimoto T, Natsuaki M, Kimura T.
  • Organizer: ESC CONGRESS 2015
  • Place of Presentation: London（UK）
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] DES 留置後の至適 DAPT 施行期間についての考察 (2015)
  • Author(s): 木村 剛
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場外（大阪市）
  • Year and Date: 2015-04-24
• [Presentation] 大規模レジストリ―の将来展望 CREDO-Kyoto Registry (2015)
  • Author(s): 木村 剛
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場外（大阪市）
  • Year and Date: 2015-04-24
• [Presentation] miR-33a/bによる細胞・臓器レベルの脂質代謝制御機構 (2015)
  • Author(s): 尾野 亘
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Microrna-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo (2014)
  • Author(s): 1)Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo (2014)
  • Author(s): 2)Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Serum HDL-C decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1). (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice. (2014)
  • Author(s): Baba O, Horie T, Ono K, Kuwabara Y, Sowa N, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway. (2014)
  • Author(s): Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Kita T, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. (2014)
  • Author(s): 尾野 亘、堀江貴裕、西野共達、北 徹、木村 剛
  • Organizer: 第5回 Molecular Cardiovascular Conference Ⅱ
  • Place of Presentation: 神戸
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] 2)飽和脂肪酸により誘導されるmicroRNA-451は、糖尿病性心筋症の増悪因子である。 (2014)
  • Author(s): 桑原康秀、堀江貴裕、馬場 理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村 剛、尾野 亘
  • Organizer: 第5回 Molecular Cardiovascular Conference Ⅱ
  • Place of Presentation: 神戸
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] MicroRNA-33 deficiency leads to high fat diet- induced obesity and insulin resistance in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Balcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] microRNA-33の動脈硬化・脂質制御における役割 (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] High impact of microRNA-33 on atherosclerosis and lipid metabolism (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会 第9回五島雄一郎賞受賞講演
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein-2 (Srebp2) regulates Srebp1 in vivo (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice (2014)
  • Author(s): Baba O, Horie T, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] SREBP-2のイントロンに存在するマイクロRNA-33はSREBP-1の発現を制御する (2014)
  • Author(s): 堀江貴裕
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する (2014)
  • Author(s): 桑原康秀
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] アポE欠損マウスにおいてマイクロRNA-33欠損は動脈硬化進展を抑制する (2014)
  • Author(s): 馬場 理
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] Nardilysin is a critical regulator of insulin secretion and glucose metabolism (2013)
  • Author(s): Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijyo S, Sakamoto J, Chen P, Kita T, Inagaki N, Kimura T, Nishi E.
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] Critical roles of a metalloendopeptidase nardilysin in cold-induced adaptive thermogenesis (2013)
  • Author(s): Hiraoka Y, T. Matsuoka, M. Ohno, K. Nishi, K. Nakamura, K, Kita, T. Kimura and E. Nishi.
  • Organizer: ASCB (American Society for Cell Biology)
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] LincRNAs regulated by pressure-overload induce hypertrophy in neonatal mouse ventricular cardiomyocytes. (2013)
  • Author(s): Kuwabara Y.
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] MicroRNA-33 deficiency reduces atherosclerosis formation in vivo. (2013)
  • Author(s): Takahiro Horie, Osamu Baba, Masataka Nishiga, Koji Hasegawa, Masayuki Yokode, Takeshi Kimura, Koh Ono.
  • Organizer: 18th Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy
  • Place of Presentation: Italy, Roma
• [Presentation] Branched-chain amino acids ameliorate heart failure in rats (2013)
  • Author(s): Tanada Y, Shioi T, Kawamoto A, Okuda J, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] Branched–chain amino acids prevent heart failure in rats (2013)
  • Author(s): Tanada Y, Shioi T, Kawamoto A, Okuda J, Kimura T
  • Organizer: Gordon Reseach Conferences, Biology of Aging
  • Place of Presentation: Lucca, Italy
• [Presentation] Characteristics of Angiographic Peri-Stent Contrast Staining (PSS) on Very Late Stent Thrombosis After Sirolimus-Eluting Stent Implantation: Morphological Classification and Antiplatelet Therapy (2013)
  • Author(s): Imai-M.
  • Organizer: European Society of Cardiology Annual Meeting
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Human Induced Pluripotent Stem Cells: A Promising Tool for Drug Discovery (2013)
  • Author(s): Sasaki-K
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Book] Annual Review 循環器2014 (2014)
  • Author(s): 尾野 亘
  • Total Pages: 315
  • Publisher: 中外医学社
• [Book] がん基盤生物学 -革新的シーズ育成に向けて-、第II部10章 (2013)
  • Author(s): 西 英一郎
  • Total Pages: 336
  • Publisher: 南山堂
• [Remarks] 京都大学医学部附属病院 循環器内科
  • URL: http://kyoto-u-cardio.jp/
• [Remarks] 京都大学医学部付属病院循環器内科
  • URL: http://kyoto-u-cardio.jp/
• [Remarks] 京都大学循環器内科
  • URL: http://kyoto-u-cardio.jp/
• [Patent(Industrial Property Rights)] マイクロＲＮＡ溶出型ステント及びそれを用いた管腔治療 (2014)
  • Inventor(s): 尾野 亘、斉藤成達、出原正康、木村剛
  • Industrial Property Rights Holder: 尾野 亘、斉藤成達、出原正康、木村剛
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-044463
  • Filing Date: 2014-03-07