Development of novel molecular diagnosis and therapy of malignant pleural mesothelioma
| Project/Area Number |
25293191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 悪性胸膜中皮腫 / バイオマーカー / 分子標的治療 / 分子診断 / プロテオミクス |
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| Outline of Final Research Achievements |
We developed ELISA to analyze the concentration of novel target molecule for malignant pleural mesothelioma diagnosis and found that a comparison between mesothelioma patients including 18 cases of stage I and the healthy controls revealed an area under the curve of 0.9 (sensitivity and specificity > 90.0%). Thus level of target molecule in serum can discriminate surgically resectable malignant pleural mesothelioma patients from healthy individuals.
We also identified another molecule, which is aberrantly up-regulated in malignant pleural mesothelioma, and conducted functional analyses of it. We identified downstream pathway of it including kinase and phosphatase. Our findings shed light on the underlying mechanisms how the tumor cells manage cellular stresses commonly cased from surrounding microenvironment at both primary and metastatic sites.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma.2016
Author(s)
Tai MC, Yanagisawa K, Nakatochi M, Hotta N, Hosono Y, Kawaguchi K, Naito M, Taniguchi H, Wakai K, Yokoi K, Takahashi T.
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Journal Title
Scientific Report
Volume: 6
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ROR1 sustains caveolae and survival signaling as a scaffold of cavin-1 and caveolin-12016
Author(s)
Yamaguchi T, Lu C, Yanagisawa K, Can Lu, Usukura J, Cheng J, Hotta N, Shimada Y, Ida R, Isomura H, Suzuki M, Fujimoto T, Takahashi T
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 10060-10060
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features2014
Author(s)
Arima C, Kajino T, Tamada Y, Imoto S, ShimadaY, Nakatochi, M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T
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Journal Title
Carcinogenesis
Volume: 35
Issue: 10
Pages: 2224-2231
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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