| Project/Area Number |
25293216
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Yamaguchi Hideki 宮崎大学, 医学部, 講師 (10305097)
Ueno Hiroaki 宮崎大学, 医学部, 助教 (00381062)
Toshinai Koji 宮崎大学, 医学部, 講師 (80381101)
Sakota Hideyuki 宮崎大学, 医学部, 講師 (50376464)
Tsuchimochi Wakaba 宮崎大学, 医学部, 医員 (90573303)
Tsubouchi Hironobu 宮崎大学, 医学部, 助教 (60573988)
Shimizu Kouichirou 宮崎大学, 医学部, 助教 (90711292)
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| Research Collaborator |
Waise T. M. Zaved
Naznin Farhana
張 維東
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 摂食調節 / 視床下部 / ペプチド / 細胞内伝達情報 / エネルギー代謝 / 交感神経 / インスリン分泌 / 糖尿病 |
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| Outline of Final Research Achievements |
We identified two novel bioactive peptides and revealed their effects on feeding and energy homeostasis.
Peptide A is expressed in the pancreatic beta cell with insulin and increased glucose stimulated insulin secretion from the islets and insulinoma-derived beta cell line MIN6. The peptide also increased glucose-induced intracellular calcium concentration. Glucose tolerant test showed the peptide increased insulin secretion in mice. The peptide is expected to be a candidate for diabetes treatment.
Peptide B consists of 20 amino acids. Intraventriclular administration of peptide B suppressed food intake dose-dependently. This peptide decreased spontaneous movement, but increased the oxygen consumption. We studied the activities of sympathetic nerve and brown adipose tissue by the peptide B stimulation.
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