| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
In this study, we have generated Anamorsin (AM) conditional knock-out mice, which delete AM in the specific organ by mating the organ-specific Cre recombinase transgenic mice, and analyzed the functions of AM in the specific organ. The defect of AM in the embryonic hematopoietic stem cells leads to anemia and embryonic lethality, which are identical with the phenotypes of AM deficient mice. The induction of AM deficiency in the hematopoietic cells in the adult mice lead to the increase of apoptosis in the hematopoietic stem cells. From these data, it was shown that AM plays important roles in both of the embryonic and adult hematopoietic stem cells.
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