A molecular mechanism of atopic manifestations of hyper-IgE syndrome
| Project/Area Number |
25293232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 原発性免疫不全症 / アトピー性皮膚炎 / STAT3 / 高IgE症候群 / 免疫不全症 / アレルギー / 免疫学 |
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| Outline of Final Research Achievements |
We identified that hyper-IgE syndrome is caused by dominant negative mutations of the STAT3 gene. Almost all the patients with hyper-IgE syndrome suffer from atopic dermatitis, but a molecular mechanism of the skin manifestation remain unidentified and no treatment other than palliative treatment is available. To address this issue, we establish a model mouse of hyper-IgE syndrome. We evaluated several skin-inflammation models and found that repetitive oxazolone application to the skin is the most useful model for atopic dermatitis by evaluating itching behavior, thickening of epidermis, recruitment of CD4+T cells and eosinophils, increased oxazolone-specific IgE antibody and Th2 cytokines.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2014
Author(s)
Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y., Matsumoto, M.
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Journal Title
J. Immunol
Volume: 192
Issue: 6
Pages: 2585-2592
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis.2014
Author(s)
Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.
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Journal Title
J. Leukoc. Biol.
Volume: 95
Issue: 4
Pages: 667-76
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The skin is an important bulwark of acquired immunity against intestinal helminths2013
Author(s)
Obata-Ninomiya, K., Ishiwata, K., Tsutsui, H., Nei, Y., Yoshikawa, S., Kawano, Y., Minegishi, Y., Ohta, N., Watanabe, N., Kanuka, H., and Karasuyama, H.
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Journal Title
J. Exp. Med.
Volume: 210
Issue: 12
Pages: 2583-2595
DOI
Related Report
Peer Reviewed
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