| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
We identified that hyper-IgE syndrome is caused by dominant negative mutations of the STAT3 gene. Almost all the patients with hyper-IgE syndrome suffer from atopic dermatitis, but a molecular mechanism of the skin manifestation remain unidentified and no treatment other than palliative treatment is available. To address this issue, we establish a model mouse of hyper-IgE syndrome. We evaluated several skin-inflammation models and found that repetitive oxazolone application to the skin is the most useful model for atopic dermatitis by evaluating itching behavior, thickening of epidermis, recruitment of CD4+T cells and eosinophils, increased oxazolone-specific IgE antibody and Th2 cytokines.
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