Neurotoxicity of general anesthetics in the developing brain
| Project/Area Number |
25293331
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
KAZAMA TOMIEI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 (40158837)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 泰司 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 准教授 (10505267)
神尾 陽子 国立研究開発法人国立精神・神経医療研究センター, その他部局等, その他 (00252445)
照井 克生 埼玉医科大学, 医学部, 教授 (90256074)
鈴木 康之 国立研究開発法人国立成育医療研究センター, その他部局等, その他 (60179265)
遠藤 昌吾 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), その他部局等, その他 (60192514)
中田 隆博 常葉大学, 公私立大学の部局等, 教授 (40273932)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 全身麻酔薬 / 発達期 / 神経毒性 / 自閉症 / マウス / 水素 / 母性行動 / 麻酔 / 小児 / 発達 / 脳 / ERK / ノックアウトマウス / 神経発達 / 細胞内情報伝達 / 臨界期 / ＥＲＫ / セボフルラン / 行動実験 |
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| Outline of Final Research Achievements |
In animal models, exposure to general anesthetics induces widespread increases in neuronal apoptosis in the developing brain. Subsequently, abnormalities in brain functioning are found as adulthood, long after the anesthetic exposure. Here we found that female mice that received neonatal exposure to sevoflurane in the developing period had impairments in maternal behaviors, indicating pervasive deficits in brain functioning. We also found that sevoflurane exposure in the developing period increased oxidative stress and mice co-administered of hydrogen gas as antioxidant during sevoflurane exposure did not exhibit the behavioral deficits. We also investigate whether there is an association between early childhood anesthesia exposure and the development of autistic traits in humans. However, no significant difference was found between autistic traits of male children who received anesthesia under 4 years of age and age-matched population sample.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.2014
Author(s)
Ulm S, Liu W, Zi M, Tsui H, Chowdhury SK, Endo S, Satoh Y, Prehar S, Wang R, Cartwright EJ, Wang X.
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Journal Title
J Mol Cell Cardiol.
Volume: 72C
Pages: 104-116
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Hepatic Extracellular Signal-Regulated Kinase 2 Suppresses Endoplasmic Reticulum Stress and Protects From Oxidative Stress and Endothelial Dysfunction2013
Author(s)
Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.
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Journal Title
J Am Heart Assoc.
Volume: 2
DOI
Related Report
Peer Reviewed
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[Presentation] 脳と水素2016
Author(s)
佐藤泰司
Organizer
第20回日本医療ガス学会学術大会
Place of Presentation
秋田
Year and Date
2016-10-15
Related Report
Invited
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[Presentation] 神経発達とセボフルラン2015
Author(s)
佐藤泰司、湯舟晋也、風間富栄
Organizer
日本麻酔科学会第６２回学術集会
Place of Presentation
神戸ポートピアホテル（兵庫県神戸市）
Year and Date
2015-05-28 – 2015-05-30
Related Report
Invited
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[Presentation] 神経発達とセボフルラン2015
Author(s)
Yasushi Satoh
Organizer
日本麻酔科学会 第62回学術集会
Place of Presentation
神戸ポートピアホテル
Year and Date
2015-05-28
Related Report
Invited
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[Book] LiSA2013
Author(s)
風間富栄
Total Pages
83
Publisher
メディカルサイエンスインターナショナル
Related Report
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