Development of multi-peptide tumor vaccine for renal cell carcinoma
| Project/Area Number |
25293336
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEVELASCO Marco 近畿大学, 医学部, 助教 (20449838)
MINAMI Takafumi 近畿大学, 医学部, 講師 (70340809)
HARADA Mamoru 島根大学, 医学部, 教授 (50260716)
YOSHIMURA Kazuhiro 近畿大学, 医学部, 教授 (20283757)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 腎細胞癌 / 癌ワクチン / ペプチドワクチン / 免疫療法 / 腎細胞がん / HLA-A24 / 癌ワクチン療法 / EPOR / HIF-1 / PDL-1 |
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| Outline of Final Research Achievements |
We have been working on the development of new MHC-class-I restricted peptide vaccines for five independent therapeutic targets and have identified a significant candidate EPOR, PDL1 and HIF1. We made the application of patents for EPOR and PDL1 peptide vaccine and are preparing the application for HIF1. Together with CA9 and VEGFR1 previously developed peptide vaccines, we established multi-peptide vaccination system using these five peptide vaccines.
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Report
(4 results)
Research Products
(10 results)
