Elucidation of regulatory mechanism of neurovascular coupling interaction in retinal circulation and clinical application for early diagnosis of diabetic retinopathy

• Project/Area Number: 25293352
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Asahikawa Medical College
• Principal Investigator: NAGAOKA Taiji 旭川医科大学, 医学部, 准教授 (00333691)
• Co-Investigator(Kenkyū-buntansha): 横田 陽匡 旭川医科大学, 医学部, 助教 (60431417) ; 大谷 真一 旭川医科大学, 大学病院, その他 (70548841) ; 高橋 淳士 旭川医科大学, 医学部, 助教 (90422047) ; 善岡 尊文 旭川医科大学, 大学病院, その他 (20548854)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 網膜微小循環 / 糖尿病網膜症 / 神経－血管連関 / 網膜循環調節 / 神経血管連関 / 一酸化窒素 / 網膜血流 / 微小循環

Outline of Final Research Achievements

We have revealed that 1) retinal glial cells may be involved with the retinal neurovascular coupling during systemic hyperoxia 2) EDHF may be involved with histamine-induced vasodilation in retinal porcine arterioles 3) habitual smoking may have some influences on retinal circulation in patients with diabetic retinopathy.

Research Products

• [Journal Article] Glial Endothelin-1 Regulates Retinal Blood Flow during Hyperoxia in Cats. (2016)
  • Author(s): Song YS, Nagaoka T, Yoshioka T, Ono S, Wada T, Nakabayashi S, Tani T, Yoshida A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 11 Issue: 11 Pages: 4962-4969
  • DOI: 10.1167/iovs.16-19599
  • NAID: 120006343723
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor (2016)
  • Author(s): Otani S, Nagaoka T, Omae T, Tanano I, Kamiya T, Ono S, Hein TW, Kuo L, Yoshida A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 11 Issue: 11 Pages: 4791-4798
  • DOI: 10.1167/iovs.15-19038
  • NAID: 120006325061
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes. (2016)
  • Author(s): Tsuneaki Omae Taiji Nagaoka Akitoshi Yoshida
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57 Issue: 3 Pages: 1345-51
  • DOI: 10.1167/iovs.15-18813
  • NAID: 120006346197
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Retinal Circulation Using Segmental-Scanning Doppler Optical Coherence Tomography in Anesthetized Cats. (2016)
  • Author(s): Nagaoka T, Tani T, Song YS, Yoshioka T, Ishibazawa A, Nakabayashi S, Akiba M, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57(7) Pages: 2936-2941
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characteristics of Retinal Neovascularization in Proliferative Diabetic Retinopathy Imaged by Optical Coherence Tomography Angiography. (2016)
  • Author(s): Ishibazawa A, Nagaoka T, Yokota H, Takahashi A, Omae T, Song YS, Takahashi T, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57(14) Pages: 6247-6255
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] En face Swept-Source Optical Coherence Tomographic Analysis of X-linked Juvenile Retinoschisis. (2016)
  • Author(s): Ono S, Takahashi A, Mase T, Nagaoka T, Yoshida A.
  • Journal Title: Am J Ophthalmol Case Rep. Volume: 2 Pages: 30-32
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Systemic Risk Factors in Bilateral Proliferative Diabetic Retinopathy Requiring Vitrectomy. (2016)
  • Author(s): Song YS, Nagaoka T*, Omae T, Yokota H, Takahashi A, Yoshida A.
  • Journal Title: Retina. Volume: 36(7) Pages: 1309-1313
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Radial Peripapillary Capillary Network Visualized Using Wide-Field Montage Optical Coherence Tomography Angiography. (2016)
  • Author(s): Mase T, Ishibazawa A, Nagaoka T, Yokota H, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 57(9)
  • NAID: 120005822574
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Short-term effect of intravitreal ranibizumab therapy on macular edema after branch retinal vein occlusion. (2016)
  • Author(s): Minami Y, Nagaoka T, Ishibazawa A, Yoshida A.
  • Journal Title: Retina. Volume: 36(9) Pages: 1726-1732
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neuroprotective effect of Water-dispersible hesperetin in retinal ischemia reperfusion injury. (2016)
  • Author(s): Shimouchi A, Yokota H, Ono S, Matsumoto C, Tamai T, Takumi H, Narayanan SP, Kimura S, Kobayashi H, Caldwell RB, Nagaoka T, Yoshida A.
  • Journal Title: Jpn J Ophthalmol Volume: 60(1) Pages: 51-61
  • NAID: 210000170569
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enhanced Vitreous Imaging Optical Coherence Tomography in Primary Macular Holes. (2016)
  • Author(s): Takahashi A, Nagaoka T, Yoshida A.
  • Journal Title: Int Ophthalmol. Volume: 36(3) Pages: 355-363
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] En-face Optical Coherence Tomography Angiography of Neovascularization Elsewhere in hemi Central Retinal Vein Occlusion. (2015)
  • Author(s): Sogawa K, Nagaoka T, Ishibazawa A, Takahashi A, Tani T, Yoshida A.
  • Journal Title: Int Med Case Rep J Volume: 8 Pages: 263-266
  • Peer Reviewed
• [Journal Article] Choroidal thickness evaluation before and after hemodialysis in patients with and without diabetes. (2015)
  • Author(s): Ishibazawa A, Nagaoka T, Minami Y, Kitahara M, Yamashita T, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56(11) Pages: 6534-6541
  • Peer Reviewed
• [Journal Article] Effect of Intravitreal Rho kinase inhibitor Ripasudil (K-115) on feline retinal microcirculation. (2015)
  • Author(s): Nakabayashi S, Kawai M, Yoshioka T, Song YS, Tani T, Yoshida A, Nagaoka T.
  • Journal Title: Exp Eye Res. Volume: 139 Pages: 132-135
  • Peer Reviewed
• [Journal Article] Imaging of the Corneal Sub-Basal Whorl-Like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients with Diabetes. (2015)
  • Author(s): Utsunomiya T, Nagaoka T, Hanada K, Omae T, Yokota H, Abiko A, Haneda M, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 56(9) Pages: 5417-5423
  • Peer Reviewed
• [Journal Article] Relationship between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients with Type 2 Diabetes Mellitus. (2015)
  • Author(s): Omae T, Nagaoka T, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 56(6) Pages: 4143-4149
  • Peer Reviewed
• [Journal Article] Vasodilatory mechanisms of unoprostone isoprophyl in isolated porcine retinal arterioles. (2015)
  • Author(s): Tanano I, Nagaoka T*, Ono S, Omae T, Otani S, Yoshida A.
  • Journal Title: Mol Vis. Volume: 21 Pages: 699-705
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study. (2015)
  • Author(s): Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, Yokota H, Yoshida A.
  • Journal Title: Am J Ophthalmol. Volume: 160(1) Pages: 35-44
  • NAID: 120005837998
  • Peer Reviewed
• [Journal Article] Anteroposterior tortuosity of the retinal vein at anterovenous crossings in healthy subjects. (2015)
  • Author(s): Sogawa K, Nagaoka T, Tani T, Yoshida A.
  • Journal Title: Curr Eye Res Volume: 40(10) Pages: 1040-1045
  • Peer Reviewed
• [Journal Article] Role of Glial Cells in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats. (2015)
  • Author(s): 10. Song YS, Nagaoka T*, Yoshioka T, Nakabayashi S, Tani T, Yoshida A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 56(12) Pages: 7551-7559
  • NAID: 120005753770
  • Peer Reviewed
• [Journal Article] Role of Neuronal Nitric Oxide Synthase in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats (2015)
  • Author(s): Yoshioka T, Nagaoka T, Yoshida A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 5 Pages: 3113-3113
  • DOI: 10.1167/iovs.14-15854
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mechanisms Responsible for Autoregulation of Retinal Blood Flow in Response to Reductions in Ocular Perfusion Pressure in Cats: Comparison of the Effects of Increased Intraocular Pressure and Systemic Hypotension. (2014)
  • Author(s): Tani T, Nagaoka T, Nakabayashi S, Yoshioka T, Yoshida A.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 55 Issue: 1 Pages: 360-367
  • DOI: 10.1167/iovs.13-12591
  • Peer Reviewed
• [Journal Article] Changes in Retinal Blood Flow in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion Before and After Intravitreal Injection of Bevacizmab (2014)
  • Author(s): Nagaoka T, Sogawa K, Yoshida A.
  • Journal Title: Retina Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Relationship between retinal fractal dimensions and retinal circulation in patients with type 2 diabetes mellitus. (2013)
  • Author(s): Nagaoka T, Yoshida A.
  • Journal Title: Current Eye Research Volume: 38 Issue: 11 Pages: 1148-1152
  • DOI: 10.3109/02713683.2013.805232
  • Peer Reviewed
• [Presentation] Role of Glial Cells in Regulating Retinal Blood Flow during Flicker-induced Hyperemia and Systemic Hyperoxia-induced Hyporemia in Cats (2016)
  • Author(s): NAGAOKA T.
  • Organizer: 2016 European Association for Vision and Eye Research Annual Meeting
  • Place of Presentation: Nice, Paris
  • Int'l Joint Research / Invited
• [Presentation] ドップラーOCT血流計による網膜血流測定～ネコ眼での検討～ (2013)
  • Author(s): 長岡泰司、谷智文、善岡尊文、中林征吾、十川健司、佐藤栄一、吉田晃敏
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] ドップラー法を用いた眼循環測定 (2013)
  • Author(s): 長岡泰司
  • Organizer: 第30回日本眼循環学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 眼循環測定の近未来 (2013)
  • Author(s): 長岡泰司
  • Organizer: 日本臨床眼科学会総会
  • Place of Presentation: 東京
  • Invited
• [Remarks] 旭川医科大学眼科学教室ホームページ
  • URL: http://www.asahikawa-med.ac.jp/dept/mc/ophtha/member/nagaoka_t.html
• [Remarks] 旭川医科大学眼科学教室ホームページ
  • URL: http://www.asahikawa-med.ac.jp/dept/mc/ophtha/